Search Results - "Holgate, Joan"

Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice by Holgate, Joan Y., Garcia, Hilary, Chatterjee, Susmita, Bartlett, Selena E.

“…Background Factors leading to the harmful consumption of substances, like alcohol and sucrose, involve a complex interaction of genes and the environment…”
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Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking by Steensland, Pia, Simms, Jeffrey A, Holgate, Joan, Richards, Jemma K, Bartlett, Selena E

“…Alcohol dependence is a disease that impacts millions of individuals worldwide. There has been some progress with pharmacotherapy for alcohol-dependent…”
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Modulation of serotonin and noradrenaline in the BLA by pindolol reduces long‐term ethanol intake by Patkar, Omkar L., Belmer, Arnauld, Holgate, Joan Y., Klenowski, Paul M., Bartlett, Selena E.

“…Repeated cycles of binge‐like alcohol consumption and abstinence change the activity of several neurotransmitter systems. Some of these changes are…”
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A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption by Holgate, Joan Y, Shariff, Masroor, Mu, Erica W H, Bartlett, Selena

“…: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption…”
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Pharmacological Consequence of the A118G μ Opioid Receptor Polymorphism on Morphine- and Fentanyl-mediated Modulation of Ca2+ Channels in Humanized Mouse Sensory Neurons by MAHMOUD, Saifeldin, THORSELL, Annika, SOMMER, Wolfgang H, HEILIG, Markus, HOLGATE, Joan K, BARTLETT, Selena E, RUIZ-VELASCO, Victor

“…The most common functional single nucleotide polymorphism of the human OPRM1 gene, A118G, has been shown to be associated with interindividual differences in…”
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The effect of varenicline on binge-like ethanol consumption in mice is β4 nicotinic acetylcholine receptor-independent by Patkar, Omkar L., Belmer, Arnauld, Tarren, Josephine R., Holgate, Joan Y., Bartlett, Selena E.

“…•Genetic ablation of β4 nicotinic acetylcholine receptor subunit does not affect ethanol drinking in mice in the drinking in the dark paradigm.•The…”
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Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake by Shariff, Masroor, Quik, Maryka, Holgate, Joan, Morgan, Michael, Patkar, Omkar L, Tam, Vincent, Belmer, Arnauld, Bartlett, Selena E

“…Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly,…”
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The α5 subunit regulates the expression and function of α4-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area by Chatterjee, Susmita, Santos, Nathan, Holgate, Joan, Haass-Koffler, Carolina L, Hopf, F Woodward, Kharazia, Viktor, Lester, Henry, Bonci, Antonello, Bartlett, Selena E

“…Human genetic association studies have shown gene variants in the α5 subunit of the neuronal nicotinic receptor (nAChR) influence both ethanol and nicotine…”
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Early Life Stress, Nicotinic Acetylcholine Receptors and Alcohol Use Disorders by Holgate, Joan Y, Bartlett, Selena E

“…Stress is a major driving force in alcohol use disorders (AUDs). It influences how much one consumes, craving intensity and whether an abstinent individual…”
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The antihypertensive drug pindolol attenuates long‐term but not short‐term binge‐like ethanol consumption in mice by Patkar, Omkar L., Belmer, Arnauld, Holgate, Joan Y., Tarren, Josephine R., Shariff, Masroor R., Morgan, Michael, Fogarty, Matthew J., Bellingham, Mark C., Bartlett, Selena E., Klenowski, Paul M.

“…Alcohol dependence is a debilitating disorder with current therapies displaying limited efficacy and/or compliance. Consequently, there is a critical need for…”
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Sex Specific Alterations in α4Nicotinic Receptor Expression in the Nucleus Accumbens by Holgate, Joan Y, Tarren, Josephine R, Bartlett, Selena E

“…: The mechanisms leading from traumatic stress to social, emotional and cognitive impairment and the development of mental illnesses are still undetermined and…”
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Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long-Evans rats by the [alpha]-2 adrenoreceptor antagonist yohimbine by Simms, Jeffrey A, Richards, Jemma K, Mill, Douglas, Kanholm, Isabel, Holgate, Joan Y, Bartlett, Selena E

“…Developing models to efficiently explore the mechanisms by which stress can mediate reinstatement of drug-seeking behavior is crucial to the development of new…”
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Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long–Evans rats by the α-2 adrenoreceptor antagonist yohimbine by Simms, Jeffrey A., Richards, Jemma K., Mill, Douglas, Kanholm, Isabel, Holgate, Joan Y., Bartlett, Selena E.

“…Rationale Developing models to efficiently explore the mechanisms by which stress can mediate reinstatement of drug-seeking behavior is crucial to the…”
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The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol by Steensland, Pia, Simms, Jeffrey A, Nielsen, Carsten K, Holgate, Joan, Bito-Onon, Jade J, Bartlett, Selena E

“…The current obesity epidemic is thought to be partly driven by over-consumption of sugar-sweetened diets and soft drinks. Loss-of-control over eating and…”
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Assessment of nicotine release from nicotine-loaded chitosan nanoparticles dry powder inhaler formulations via locomotor activity of C57BL/6 mice by Wang, Hui, Holgate, Joan, Bartlett, Selena, Islam, Nazrul

“…Locomotor activity of mice after inhaling nicotine nanoparticles through a delivery chamber. [Display omitted] This study aimed to assess the activity of…”
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The α5 Neuronal Nicotinic Acetylcholine Receptor Subunit Plays an Important Role in the Sedative Effects of Ethanol But Does Not Modulate Consumption in Mice by Santos, Nathan, Chatterjee, Susmita, Henry, Andrea, Holgate, Joan, Bartlett, Selena E.

“…Background Alcohol use disorders (AUDs) are a major public health problem, and the few treatment options available to those seeking treatment offer only modest…”
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The alpha 5 Neuronal Nicotinic Acetylcholine Receptor Subunit Plays an Important Role in the Sedative Effects of Ethanol But Does Not Modulate Consumption in Mice by Santos, Nathan, Chatterjee, Susmita, Henry, Andrea, Holgate, Joan, Bartlett, Selena E

“…Alcohol use disorders (AUDs) are a major public health problem, and the few treatment options available to those seeking treatment offer only modest success…”
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Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats by Bito-Onon, Jade J., Simms, Jeffrey A., Chatterjee, Susmita, Holgate, Joan, Bartlett, Selena E.

“…ABSTRACT Alcohol and nicotine use disorders are often treated as separate diseases, despite evidence that approximately 80–90% of alcohol dependent individuals…”
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Partial Agonists of the α3β4 Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats by CHATTERJEE, Susmita, STEENSLAND, Pia, SIMMS, Jeffrey A, HOLGATE, Joan, COE, Jotham W, HURST, Raymond S, SHAFFER, Christopher L, LOWE, John, ROLLEMA, Hans, BARTLETT, Selena E

“…Alcohol use disorders (AUDs) impact millions of individuals and there remain few effective treatment strategies. Despite evidence that neuronal nicotinic…”
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The [alpha]5 Neuronal Nicotinic Acetylcholine Receptor Subunit Plays an Important Role in the Sedative Effects of Ethanol But Does Not Modulate Consumption in Mice by Santos, Nathan, Chatterjee, Susmita, Henry, Andrea, Holgate, Joan, Bartlett, Selena E

“…Background Alcohol use disorders (AUDs) are a major public health problem, and the few treatment options available to those seeking treatment offer only modest…”
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