Search Results - "Holford, Mande"

Microscopic marvels: Decoding the role of micropeptides in innate immunity by Naidu, Praveena, Holford, Mandë

“…The innate immune response is under selection pressures from changing environments and pathogens. While sequence evolution can be studied by comparing rates of…”
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Venoms to the rescue by Holford, Mandë, Daly, Marymegan, King, Glenn F, Norton, Raymond S

“…Insights into the evolutionary biology of venoms are leading to therapeutic advances Venomous animals have been admired and feared since prehistoric times, and…”
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Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides by Achimba, Favour, Faezov, Bulat, Cohen, Brandon, Dunbrack, Roland, Holford, Mandë

“…The regulation of cellular processes by ion channels has become central to the study of cancer mechanisms. Designing molecules that can modify ion channels…”
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Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers by Anand, Prachi, O’Neil, Alison, Lin, Emily, Douglas, Trevor, Holford, Mandë

“…The blood brain barrier (BBB) is often an insurmountable obstacle for a large number of candidate drugs, including peptides, antibiotics and chemotherapeutic…”
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Phylogenomics of Neogastropoda: The Backbone Hidden in the Bush by Fedosov, Alexander E, Zaharias, Paul, Lemarcis, Thomas, Modica, Maria Vittoria, Holford, Mandë, Oliverio, Marco, Kantor, Yuri I, Puillandre, Nicolas

“…Abstract The molluskan order Neogastropoda encompasses over 15,000 almost exclusively marine species playing important roles in benthic communities and in the…”
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From Flatland to Jupiter: Searching for Rules of Interaction Across Biological Scales by Grillo, Claudia A, Holford, Mandë, Walter, Nils G

“…Synopsis In this future-spanning perspective, we examine how an agent-based model could be used to define general rules for interactions across biological…”
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Induced Disassembly of a Virus-like Particle under Physiological Conditions for Venom Peptide Delivery by Kelly, M. Patrick, Napolitano, Tanya, Anand, Prachi, Ho, Justin S. K, Jabeen, Shakeela, Kuppan, Jessica, Manir, Sujoy, Holford, Mandë

“…Virus-like particles (VLPs) show considerable promise for the in vivo delivery of therapeutic compounds such as bioactive venom peptides. While loading and…”
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Discovering Venom-Derived Drug Candidates Using Differential Gene Expression by Romano, Joseph D, Li, Hai, Napolitano, Tanya, Realubit, Ronald, Karan, Charles, Holford, Mandë, Tatonetti, Nicholas P

“…Venoms are a diverse and complex group of natural toxins that have been adapted to treat many types of human disease, but rigorous computational approaches for…”
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Macroevolutionary Analyses Suggest That Environmental Factors, Not Venom Apparatus, Play Key Role in Terebridae Marine Snail Diversification by Modica, Maria Vittoria, Gorson, Juliette, Fedosov, Alexander E., Malcolm, Gavin, Terryn, Yves, Puillandre, Nicolas, Holford, Mandë

“…How species diversification occurs remains an unanswered question in predatory marine invertebrates, such as sea snails of the family Terebridae. However, the…”
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Beach to Bench to Bedside: Marine Invertebrate Biochemical Adaptations and Their Applications in Biotechnology and Biomedicine by Verdes, Aida, Holford, Mandë

“…The ocean covers more than 70% of the surface of the planet and harbors very diverse ecosystems ranging from tropical coral reefs to the deepest ocean…”
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Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models by Leffler, Abba E., Kuryatov, Alexander, Zebroski, Henry A., Powell, Susan R., Filipenko, Petr, Hussein, Adel K., Gorson, Juliette, Heizmann, Anna, Lyskov, Sergey, Tsien, Richard W., Poget, Sébastien F., Nicke, Annette, Lindstrom, Jon, Rudy, Bernardo, Bonneau, Richard, Holford, Mandë

“…Venom peptide toxins such as conotoxins play a critical role in the characterization of nicotinic acetylcholine receptor (nAChR) structure and function and…”
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Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions by Cerullo, Antonio R., McDermott, Maxwell B., Pepi, Lauren E., Liu, Zhi-Lun, Barry, Diariou, Zhang, Sheng, Yang, Xu, Chen, Xi, Azadi, Parastoo, Holford, Mande, Braunschweig, Adam B.

“…Every animal secretes mucus, placing them among the most diverse biological materials. Mucus hydrogels are complex mixtures of water, ions, carbohydrates, and…”
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Selective Inhibition of Liver Cancer Cells Using Venom Peptide by Anand, Prachi, Filipenko, Petr, Huaman, Jeannette, Lyudmer, Michael, Hossain, Marouf, Santamaria, Carolina, Huang, Kelly, Ogunwobi, Olorunseun O, Holford, Mandë

“…Increasingly cancer is being viewed as a channelopathy because the passage of ions via ion channels and transporters mediate the regulation of tumor cell…”
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From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins by Verdes, Aida, Anand, Prachi, Gorson, Juliette, Jannetti, Stephen, Kelly, Patrick, Leffler, Abba, Simpson, Danny, Ramrattan, Girish, Holford, Mandë

“…Animal venoms comprise a diversity of peptide toxins that manipulate molecular targets such as ion channels and receptors, making venom peptides attractive…”
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Advancing Discovery of Snail Mucins Function and Application by McDermott, Maxwell, Cerullo, Antonio R, Parziale, James, Achrak, Eleonora, Sultana, Sharmin, Ferd, Jennifer, Samad, Safiyah, Deng, William, Braunschweig, Adam B, Holford, Mandë

“…Mucins are a highly glycosylated protein family that are secreted by animals for adhesion, hydration, lubrication, and other functions. Despite their ubiquity,…”
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A tale of two states by Holford, Mandë, Nichols, Rodney

“…On 20 July 2015, the United States reopened its embassy in Havana, Cuba, after more than 50 years, creating a spirit of engagement between the two Cold War…”
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Nature's Palette: Characterization of Shared Pigments in Colorful Avian and Mollusk Shells by Verdes, Aida, Cho, Wooyoung, Hossain, Marouf, Brennan, Patricia L R, Hanley, Daniel, Grim, Tomáš, Hauber, Mark E, Holford, Mandë

“…Pigment-based coloration is a common trait found in a variety of organisms across the tree of life. For example, calcareous avian eggs are natural structures…”
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GeoForge: investigating integrated virtual reality and personalized websites for collaboration in middle school science by Brenner, Corinne, DesPortes, Kayla, Ochoa Hendrix, Jessica, Holford, Mandë

“…Purpose This paper aims to describe the design and user testing of GeoForge, a multiple-player digital learning experience for middle school that leverages…”
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Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity by Eriksson, Anders, Anand, Prachi, Gorson, Juliette, Grijuc, Corina, Hadelia, Elina, Stewart, James C., Holford, Mandë, Claridge-Chang, Adam

“…The number of newly discovered peptides from the transcriptomes and proteomes of animal venom arsenals is rapidly increasing, resulting in an abundance of…”
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Using 3D printed eggs to examine the egg-rejection behaviour of wild birds by Igic, Branislav, Nunez, Valerie, Voss, Henning U, Croston, Rebecca, Aidala, Zachary, López, Analía V, Van Tatenhove, Aimee, Holford, Mandë E, Shawkey, Matthew D, Hauber, Mark E

“…The coevolutionary relationships between brood parasites and their hosts are often studied by examining the egg rejection behaviour of host species using…”
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