Search Results - "Holenz, J"

Naphthylisoquinoline alkaloids against malaria: evaluation of the curative potentials of dioncophylline C and dioncopeltine A against Plasmodium berghei in vivo by FRANCOIS, G, TIMPERMAN, G, ELING, W, AKE ASSI, L, HOLENZ, J, BRINGMANN, G

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Population pharmacokinetic analysis of BIA 28-6156, an allosteric activator of beta-glucocerebrosidase (GCase), in Parkinson’s Disease patients and healthy volunteers by Ronaghinia, A.A., Soares, R., Magalhães, L.M., Hilt, D.C., Holenz, J.

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Advances in Lead Generation by Holenz, Joerg, Stoy, Patrick

“…[Display omitted] Lead Generation represents a critical drug discovery phase where chemical starting points and their respective mechanism of action, quality,…”
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Chronic 5‐HT6 receptor modulation by E‐6837 induces hypophagia and sustained weight loss in diet‐induced obese rats by Fisas, A, Codony, X, Romero, G, Dordal, A, Giraldo, J, Mercé, R, Holenz, J, Vrang, N, Sørensen, R V, Heal, D, Buschmann, H, Pauwels, P J

“…British Journal of Pharmacology (2007) 151, 564; doi:10.1038/sj.bjp.0707268…”
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A structural perspective on the interaction between glucocerebrosidase and the positive allosteric modulator BIA 28-6156 by Dantas, J.M., Cerqueira, N.M.F.S.A., Batalha, V.L., Kiss, L.E., Karoli, T., Holenz, J.

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Opicapone Effect on Sleep Disorders in Fluctuating Parkinson’s Disease Patients: Findings from the OASIS Trial by Ferreira, J.J., Gago, M.F., Costa, R., Fonseca, M.M.F., Almeida, J., Rocha, J.-F., Holenz, J., Trenkwalder, C.

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Opicapone as Add-on to Levodopa in Parkinson's Patients without Motor Complications: Preliminary Data from EPSILON by Ferreira, J.J., Rascol, O., Stocchi, F., Antonini, A., Moreira, J., Castilla-Fernández, G., Rocha, J.-F., Holenz, J., Poewe, W.

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Opicapone as First-Line Strategy for the Treatment of Wearing-off in Patients with Parkinson's Disease by Ferreira, J.J., Lee, J.Y., Ma, H.I., Jeon, B., Poewe, W., Antonini, A., Stocchi, F., Rodrigues, D.M., Fonseca, M., Rocha, J.F., Castilla-Fernández, G., Holenz, J., Rascol, O.

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Profile of Glucocerebrosidase 1 (GCASE) activity and Glucosylsphingosine levels in GBA-PD, PD patients and healthy volunteers by Pires, N., Igreja, B., Castilla-Fernández, G., Bakker, W., Çakici, M., Vissers, M., Kremer, P., Almeida, D., Magalhães, L., Holenz, J.

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A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo by CHIMANUKA, B, FRANCOIS, G, TIMPERMAN, G, VANDER HEYDEN, Y, HOLENZ, J, PLAIZIER-VERCAMMEN, J, BRINGMANN, G

“…Chloroquine, artemether and dioncophylline B efficacy against Plasmodium chabaudi was compared. One intraperitoneal injection (10 mg/kg body weight) was given…”
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Larvicidal activity of the naphthylisoquinoline alkaloid dioncophylline A against the malaria vector Anopheles stephensi by François, G., Van Looveren, M., Timperman, G., Chimanuka, B., AkéAssi, L., Holenz, J., Bringmann, G.

“…The larvicidal activity of dioncophylline A, a naphthylisoquinoline alkaloid derived from the tropical vine Triphyophyllum peltatum (Dioncophyllaceae), was…”
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Constituents of Picralima nitida display pronounced inhibitory activities against asexual erythrocytic forms of Plasmodium falciparum in vitro by François, G., AkéAssi, L., Holenz, J., Bringmann, G.

“…The antiplasmodial activities of organic and aqueous extracts from the West African plant Picralima nitida (Apocynaceae) were examined in an in vitro model,…”
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Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents by HOLENZ, Jörg, PAUWELS, Petrus J, DIAZ, José Luis, MERCE, Ramon, CODONY, Xavier, BUSCHMANN, Helmut

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Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from dioncophyllaceae and ancistrocladaceae species by François, G., Steenackers, T., Timperman, G., Assi, L.Aké, Haller, R.D., Bär, S., Isahakia, M.A., Robertson, S.A., Zhao, C., De Souza, N.J., Holenz, J., Bringmann, G.

“…Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceae and…”
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Medicinal Chemistry Driven Approaches Toward Novel and Selective Serotonin 5-HT6 Receptor Ligands by Holenz, Jörg, Mercè, Ramon, Díaz, José Luis, Guitart, Xavier, Codony, Xavier, Dordal, Alberto, Romero, Gonzalo, Torrens, Antoni, Mas, Josep, Andaluz, Blas, Hernández, Susana, Monroy, Xavier, Sánchez, Elisabeth, Hernández, Enrique, Pérez, Raquel, Cubí, Roger, Sanfeliu, Olga, Buschmann, Helmut

“…Based on a medicinal chemistry guided hypothetical pharmacophore model, novel series of indolyl sulfonamides have been designed and prepared as selective and…”
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Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents

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Naphthylisoquinoline alkaloids exhibit strong growth-inhibiting activities against Plasmodium falciparum and P. berghei in vitro--structure-activity relationships of dioncophylline C by François, G, Timperman, G, Holenz, J, Aké Assi, L, Geuder, T, Maes, L, Dubois, J, Hanocq, M, Bringmann, G

“…The growth-inhibiting activities of naturally occurring naphthylisoquinoline alkaloids against asexual blood stages of Plasmodium falciparum (NF 54, clone…”
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Medicinal chemistry strategies to 5-HT sub(6) receptor ligands as potential cognitive enhancers and antiobesity agents by Holenz, J, Pauwels, P J, Diaz, J L, Merce, R, Codony, X, Buschmann, H

“…Although the 5-hydroxytryptamine sub(6) (5-HT sub(6)) receptor was discovered only recently, its almost exclusive distribution in the brain makes it a…”
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Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716 : synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides by JAGEROVIC, Nadine, HERNANDEZ-FOLGADO, Laura, HOLENZ, Jörg, ALKORTA, Ibon, GOYA, Pilar, MARTIN, Maria Isabel, DANNERT, Maria Teresa, ALSASUA, Angela, FRIGOLA, Jordi, CUBERES, Maria Rosa, DORDAL, Alberto

“…A series of 1,2,4-triazole-3-carboxamides has been prepared from alkyl-1,2,4-triazole-3-carboxylates under mild conditions. The ability of these triazoles to…”
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Medicinal Chemistry approaches toward novel, selective 5-HT6 receptor ligands by J. Holenz, P. J. Pauwels, J. L. Diaz, R. Merce, X. Codony, H. Buschmann

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