Search Results - "Holdt, Lesca M."

Revisiting biomarker discovery by plasma proteomics by Geyer, Philipp E, Holdt, Lesca M, Teupser, Daniel, Mann, Matthias

“…Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support…”
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Circular RNAs as Therapeutic Agents and Targets by Holdt, Lesca M, Kohlmaier, Alexander, Teupser, Daniel

“…It has recently been reported that thousands of covalently linked circular RNAs (circRNAs) are expressed from human genomes. circRNAs emerge during RNA…”
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Inflammatory cytokines in general and central obesity and modulating effects of physical activity by Schmidt, Frank M, Weschenfelder, Julia, Sander, Christian, Minkwitz, Juliane, Thormann, Julia, Chittka, Tobias, Mergl, Roland, Kirkby, Kenneth C, Faßhauer, Mathias, Stumvoll, Michael, Holdt, Lesca M, Teupser, Daniel, Hegerl, Ulrich, Himmerich, Hubertus

“…Chronic systemic inflammation in obesity originates from local immune responses in visceral adipose tissue. However, assessment of a broad range of…”
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Plasma Proteome Profiling to Assess Human Health and Disease by Geyer, Philipp E, Kulak, Nils A, Pichler, Garwin, Holdt, Lesca M, Teupser, Daniel, Mann, Matthias

“…Proteins in the circulatory system mirror an individual's physiology. In daily clinical practice, protein levels are generally determined using single-protein…”
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Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans by Holdt, Lesca M., Stahringer, Anika, Sass, Kristina, Pichler, Garwin, Kulak, Nils A., Wilfert, Wolfgang, Kohlmaier, Alexander, Herbst, Andreas, Northoff, Bernd H., Nicolaou, Alexandros, Gäbel, Gabor, Beutner, Frank, Scholz, Markus, Thiery, Joachim, Musunuru, Kiran, Krohn, Knut, Mann, Matthias, Teupser, Daniel

“…Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular…”
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Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms by Sadler, Rebecca, Cramer, Julia V, Heindl, Steffanie, Kostidis, Sarantos, Betz, Dene, Zuurbier, Kielen R, Northoff, Bernd H, Heijink, Marieke, Goldberg, Mark P, Plautz, Erik J, Roth, Stefan, Malik, Rainer, Dichgans, Martin, Holdt, Lesca M, Benakis, Corinne, Giera, Martin, Stowe, Ann M, Liesz, Arthur

“…Recovery after stroke is a multicellular process encompassing neurons, resident immune cells, and brain-invading cells. Stroke alters the gut microbiome, which…”
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Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks by Holdt, Lesca M, Hoffmann, Steve, Sass, Kristina, Langenberger, David, Scholz, Markus, Krohn, Knut, Finstermeier, Knut, Stahringer, Anika, Wilfert, Wolfgang, Beutner, Frank, Gielen, Stephan, Schuler, Gerhard, Gäbel, Gabor, Bergert, Hendrik, Bechmann, Ingo, Stadler, Peter F, Thiery, Joachim, Teupser, Daniel

“…The chromosome 9p21 (Chr9p21) locus of coronary artery disease has been identified in the first surge of genome-wide association and is the strongest genetic…”
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Plasma Proteome Profiling to detect and avoid sample‐related biases in biomarker studies by Geyer, Philipp E, Voytik, Eugenia, Treit, Peter V, Doll, Sophia, Kleinhempel, Alisa, Niu, Lili, Müller, Johannes B, Buchholtz, Marie‐Luise, Bader, Jakob M, Teupser, Daniel, Holdt, Lesca M, Mann, Matthias

“…Plasma and serum are rich sources of information regarding an individual's health state, and protein tests inform medical decision making. Despite major…”
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multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection by Hoffmann, Steve, Otto, Christian, Doose, Gero, Tanzer, Andrea, Langenberger, David, Christ, Sabina, Kunz, Manfred, Holdt, Lesca M, Teupser, Daniel, Hackermüller, Jörg, Stadler, Peter F

“…Numerous high-throughput sequencing studies have focused on detecting conventionally spliced mRNAs in RNA-seq data. However, non-standard RNAs arising through…”
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Long Noncoding RNA ANRIL : Lnc-ing Genetic Variation at the Chromosome 9p21 Locus to Molecular Mechanisms of Atherosclerosis by Holdt, Lesca M, Teupser, Daniel

“…Ever since the first genome-wide association studies (GWAS) on coronary artery disease (CAD), the Chr9p21 risk locus has emerged as a top signal in GWAS of…”
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High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion by Geyer, Philipp E, Arend, Florian M, Doll, Sophia, Louiset, Marie‐Luise, Virreira Winter, Sebastian, Müller‐Reif, Johannes B, Torun, Furkan M, Weigand, Michael, Eichhorn, Peter, Bruegel, Mathias, Strauss, Maximilian T, Holdt, Lesca M, Mann, Matthias, Teupser, Daniel

“…A deeper understanding of COVID‐19 on human molecular pathophysiology is urgently needed as a foundation for the discovery of new biomarkers and therapeutic…”
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Comparison of whole blood RNA preservation tubes and novel generation RNA extraction kits for analysis of mRNA and MiRNA profiles by Häntzsch, Madlen, Tolios, Alexander, Beutner, Frank, Nagel, Dorothea, Thiery, Joachim, Teupser, Daniel, Holdt, Lesca M

“…Whole blood expression profiling is frequently performed using PAXgene (Qiagen) or Tempus (Life Technologies) tubes. Here, we compare 6 novel generation RNA…”
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Whole genome sequencing of Brucella melitensis isolated from 57 patients in Germany reveals high diversity in strains from Middle East by Georgi, Enrico, Walter, Mathias C, Pfalzgraf, Marie-Theres, Northoff, Bernd H, Holdt, Lesca M, Scholz, Holger C, Zoeller, Lothar, Zange, Sabine, Antwerpen, Markus H

“…Brucellosis, a worldwide common bacterial zoonotic disease, has become quite rare in Northern and Western Europe. However, since 2014 a significant increase of…”
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Preanalytical Conditions and DNA Isolation Methods Affect Telomere Length Quantification in Whole Blood by Tolios, Alexander, Teupser, Daniel, Holdt, Lesca M

“…Telomeres are located at chromosome ends and their length (TL) has been associated with aging and human diseases such as cancer. Whole blood DNA is frequently…”
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High susceptibility to fatty liver disease in two-pore channel 2-deficient mice by Grimm, Christian, Holdt, Lesca M., Chen, Cheng-Chang, Hassan, Sami, Müller, Christoph, Jörs, Simone, Cuny, Hartmut, Kissing, Sandra, Schröder, Bernd, Butz, Elisabeth, Northoff, Bernd, Castonguay, Jan, Luber, Christian A., Moser, Markus, Spahn, Saskia, Lüllmann-Rauch, Renate, Fendel, Christina, Klugbauer, Norbert, Griesbeck, Oliver, Haas, Albert, Mann, Matthias, Bracher, Franz, Teupser, Daniel, Saftig, Paul, Biel, Martin, Wahl-Schott, Christian

“…Endolysosomal organelles play a key role in trafficking, breakdown and receptor-mediated recycling of different macromolecules such as low-density lipoprotein…”
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Late-pregnancy dysglycemia in obese pregnancies after negative testing for gestational diabetes and risk of future childhood overweight: An interim analysis from a longitudinal mother-child cohort study by Gomes, Delphina, von Kries, Rüdiger, Delius, Maria, Mansmann, Ulrich, Nast, Martha, Stubert, Martina, Langhammer, Lena, Haas, Nikolaus A, Netz, Heinrich, Obermeier, Viola, Kuhle, Stefan, Holdt, Lesca M, Teupser, Daniel, Hasbargen, Uwe, Roscher, Adelbert A, Ensenauer, Regina

“…Maternal pre-conception obesity is a strong risk factor for childhood overweight. However, prenatal mechanisms and their effects in susceptible gestational…”
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Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells by Plesch, Eva, Chen, Cheng-Chang, Butz, Elisabeth, Scotto Rosato, Anna, Krogsaeter, Einar K, Yinan, Hua, Bartel, Karin, Keller, Marco, Robaa, Dina, Teupser, Daniel, Holdt, Lesca M, Vollmar, Angelika M, Sippl, Wolfgang, Puertollano, Rosa, Medina, Diego, Biel, Martin, Wahl-Schott, Christian, Bracher, Franz, Grimm, Christian

“…Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these…”
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Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood by Burkhardt, Ralph, Kirsten, Holger, Beutner, Frank, Holdt, Lesca M, Gross, Arnd, Teren, Andrej, Tönjes, Anke, Becker, Susen, Krohn, Knut, Kovacs, Peter, Stumvoll, Michael, Teupser, Daniel, Thiery, Joachim, Ceglarek, Uta, Scholz, Markus

“…Profiling amino acids and acylcarnitines in whole blood spots is a powerful tool in the laboratory diagnosis of several inborn errors of metabolism. Emerging…”
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Molecular functions and specific roles of circRNAs in the cardiovascular system by Holdt, Lesca M., Kohlmaier, Alexander, Teupser, Daniel

“…As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression…”
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Molecular roles and function of circular RNAs in eukaryotic cells by Holdt, Lesca M., Kohlmaier, Alexander, Teupser, Daniel

“…Protein-coding and noncoding genes in eukaryotes are typically expressed as linear messenger RNAs, with exons arranged colinearly to their genomic order…”
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