Search Results - "Holder, Michelle J"

Inflammation and Regeneration in the Dentin-Pulp Complex: A Double-edged Sword by Cooper, Paul R., BSc, Holder, Michelle J., BSc, Smith, Anthony J., BSc, PhD

“…Abstract Dental tissue infection and disease result in acute and chronic activation of the innate immune response, which is mediated by molecular and cellular…”
Get full text

Neutrophil Extracellular Traps Exert Potential Cytotoxic and Proinflammatory Effects in the Dental Pulp by Holder, Michelle J., Wright, Helen J., Couve, Eduardo, Milward, Michael R., Cooper, Paul R.

“…Neutrophil extracellular traps (NETs) are an important innate immune mechanism aimed at limiting the dissemination of bacteria within tissues and localizing…”
Get full text

Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells by Serafeim, Adamantios, Holder, Michelle J., Grafton, Gillian, Chamba, Anita, Drayson, Mark T., Luong, Quang T., Bunce, Christopher M., Gregory, Christopher D., Barnes, Nicholas M., Gordon, John

“…Selective serotonin reuptake inhibitors (SSRIs) are the treatment of choice for clinical depression and a range of anxiety-related disorders. They are well…”
Get full text

Dopamine Targets Cycling B Cells Independent of Receptors/Transporter for Oxidative Attack: Implications for Non-Hodgkin's Lymphoma by Meredith, Elizabeth J., Holder, Michelle J., Rosén, Anders, Lee, Adrian Drake, Dyer, Martin J. S., Barnes, Nicholas M., Gordon, John

“…Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their…”
Get full text

SLC6A4 expression and anti-proliferative responses to serotonin transporter ligands chlomipramine and fluoxetine in primary B-cell malignancies by Chamba, Anita, Holder, Michelle J, Jarrett, Ruth F, Shield, Lesley, Toellner, Kai M, Drayson, Mark T, Barnes, Nicholas M, Gordon, John

“…Abstract B-cell lines of diverse neoplastic origin express the serotonin transporter (SERT/SLC6A4) and growth arrest in response to SERT-ligands, including the…”
Get full text

The dark art of light measurement: accurate radiometry for low-level light therapy by Hadis, Mohammed A., Zainal, Siti A., Holder, Michelle J., Carroll, James D., Cooper, Paul R., Milward, Michael R., Palin, William M.

“…Lasers and light-emitting diodes are used for a range of biomedical applications with many studies reporting their beneficial effects. However, three main…”
Get full text

Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells by Pound, J D, Challa, A, Holder, M J, Armitage, R J, Dower, S K, Fanslow, W C, Kikutani, H, Paulie, S, Gregory, C D, Gordon, J

“…Eight different CD40 mAb shared with soluble trimeric CD40 ligand (sCD40LT) the capacity to rescue germinal center (GC) B cells from spontaneous apoptosis and…”
Get full text

Close encounters of the monoamine kind: immune cells betray their nervous disposition by Meredith, Elizabeth J., Chamba, Anita, Holder, Michelle J., Barnes, Nicholas M., Gordon, John

“…Summary Here we review the evidence for immune cells expressing multiple components of the serotonergic and dopaminergic systems that are more commonly…”
Get full text

The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics by Meredith, Elizabeth J, Holder, Michelle J, Chamba, Anita, Challa, Anita, Drake-Lee, Adrian, Bunce, Christopher M, Drayson, Mark T, Pilkington, Geoffrey, Blakely, Randy D, Dyer, Martin J S, Barnes, Nicholas M, Gordon, John

“…Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in…”
Get full text

Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine (‘ecstasy’) through iterative chemical redesign: mechanisms and pathways to cell death by Wasik, Agata M., Gandy, Michael N., McIldowie, Matthew, Holder, Michelle J., Chamba, Anita, Challa, Anita, Lewis, Katie D., Young, Stephen P., Scheel-Toellner, Dagmar, Dyer, Martin J., Barnes, Nicholas M., Piggott, Matthew J., Gordon, John

“…Summary While 3,4-methylenedioxymethamphetamine (MDMA/‘ecstasy’) is cytostatic towards lymphoma cells in vitro, the concentrations required militate against…”
Get full text

Low level light therapy (LLLT) for the treatment and management of dental and oral diseases by Milward, Michael R, Holder, Michelle J, Palin, William M, Hadis, Mohammed A, Carroll, James D, Cooper, Paul R

“…Low Level Light (Laser) Therapy (LLLT) is the direct application of light to stimulate cell and tissue responses (photobiomodulation) to promote healing,…”
Get full text

Characterisation of the endogenous human peripheral serotonin transporter SLC6A4 reveals surface expression without N -glycosylation by Chamba, Anita, Holder, Michelle J, Barnes, Nicholas M, Gordon, John

“…Abstract RT-PCR confirmed that human cell lines of diverse peripheral origins express transcripts for the serotonin transporter ( sert / slc6a4 ). Molecular…”
Get full text

Dynamic interplay between the neutral glycosphingolipid CD77/Gb3 and the therapeutic antibody target CD20 within the lipid bilayer of model B lymphoma cells by Jarvis, Rosemary M, Chamba, Anita, Holder, Michelle J, Challa, Anita, Smith, Daniel C, Hodgkin, Matthew N, Lord, J Michael, Gordon, John

“…The centroblast-specific differentiation marker CD77 (Gb(3)), is the receptor for Shiga-like toxin (SLT). The dynamic relationship between Gb(3)/CD77 and key…”
Get full text

Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells by Challa, Anita, Eliopoulos, Aristides G., Holder, Michelle J., Burguete, Alondra Schweizer, Pound, John D., Chamba, Anita, Grafton, Gillian, Armitage, Richard J., Gregory, Christopher D., Martinez-Valdez, Hector, Young, Lawrence, Gordon, John

“…Population size is governed through cells reacting to a variety of intrinsic and extrinsic cues. Tumors, while liberated from many of the homeostatic…”
Get full text

Lymphoma cells protected from apoptosis by dysregulated bcl-2 continue to bind Annexin V in response to B-cell receptor engagement: A cautionary tale by Holder, Michelle J., Barnes, Nicholas M., Gregory, Christopher D., Gordon, John

“…Translocation of phosphatidylserine (PS) from the inner to outer leaflet of the surface membrane lipid bilayer, a characteristic early event of cells entering…”
Get full text

Improved access to CD20 following B cell receptor cross-linking at Burkitt’s lymphoma cell surfaces by Holder, Michelle J., Chamba, Anita, Hardie, Debbie L., Deans, Julie P., Gordon, John

“…Here we report that B cell receptor (BCR) engagement rapidly improves the capacity of CD20 to be accessed by cognate antibody at model Burkitt’s lymphoma cell…”
Get full text

The extrafollicular‐to‐follicular transition of human B lymphocytes: induction of functional globotriaosylceramide (CD77) on high threshold occupancy of CD40 by McCloskey, Natalie, Pound, John D., Holder, Michelle J., Williams, Julie M., Roberts, Lynne M., Lord, J. Michael, Gordon, John

“…Amongst lymphocytes, expression of CD77 (globotriaosylceramide, Gb3) is exclusive to B cells of the germinal center (GC). Its acquisition by extrafollicular B…”
Get full text

A subset of anti-CD21 antibodies promote the rescue of germinal center B cells from apoptosis by Bonnefoy, J Y, Henchoz, S, Hardie, D, Holder, M J, Gordon, J

“…Germinal center cells (GCC) are programmed to die by apoptosis unless they receive a positive signal for rescue. The primary signal in vivo is believed to be…”
Get more information

The serotonin transporter (SLC6A4) is present in B‐cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics by Meredith, Elizabeth J., Holder, Michelle J., Chamba, Anita, Challa, Anita, Lee, Adrian Drake, Bunce, Christopher M., Drayson, Mark T., Pilkington, Geoffrey, Blakely, Randy D., Dyer, Martin J. S., Barnes, Nicholas M., Gordon, John

“…ABSTRACTFollowing our previous description of the serotonin transporter (SERT) acting as a conduit to 5‐hydroxytryptamine (5‐HT)‐mediated apoptosis,…”
Get full text

Dynamic interplay between the neutral glycosphingolipid CD77/Gb 3 and the therapeutic antibody target CD20 within the lipid bilayer of model B lymphoma cells by Jarvis, Rosemary M., Chamba, Anita, Holder, Michelle J., Challa, Anita, Smith, Daniel C., Hodgkin, Matthew N., Lord, J. Michael, Gordon, John

“…The centroblast-specific differentiation marker CD77 (Gb 3), is the receptor for Shiga-like toxin (SLT). The dynamic relationship between Gb 3/CD77 and key…”
Get full text