Search Results - "Holder, A T"
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Enhancement of FSH bioactivity in vivo using site-specific antisera
Published in Journal of endocrinology (01-03-1997)“…The ability of site-specific antipeptide antisera to enhance the biological activity of ovine FSH (oFSH) in vivo was investigated using hypopituitary Snell…”
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2
A monoclonal antibody to human insulin-like growth factor-I: characterization, use in radioimmunoassay and effect on the biological activities of the growth factor
Published in Journal of molecular endocrinology (01-05-1989)“…A monoclonal antibody (BPL-M23) to insulin-like growth factor-I (IGF-I) was obtained following immunization of BALB/c mice with human IGF-I conjugated to…”
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3
Monoclonal antibody enhancement of FSH-induced uterine growth in snell dwarf mice
Published in Journal of endocrinology (01-03-1993)“…The enhancing effect of bovine FSH monoclonal antibody (bFSH-MAb) on the gonadotrophic activity of FSH was investigated in dwarf mice using a uterine weight…”
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4
Growth hormone control of tissue protein metabolism in dwarf mice: enhancement by a monoclonal antibody
Published in Journal of endocrinology (01-03-1992)“…Monoclonal antibody (MAb) to GH has been shown to increase the anabolic response induced by the hormone in individual tissues of dwarf mice. Dwarf mice were…”
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5
Cross-linked growth hormone dimers have enhanced biological activity
Published in European journal of endocrinology (01-04-1998)“…In this study we have investigated the effect on the bioactivity of pituitary-derived human growth hormone (hGH) and recombinant bovine (b) GH after the…”
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6
Monoclonal antibody enhanced stimulation of human growth hormone action in vitro using ovine costal cartilage growth plate chondrocytes
Published in Hormone and metabolic research (01-10-1998)“…Investigations into the mechanism underlying antibody-mediated enhancement of growth hormone action have been hampered by the lack of an in vitro assay system…”
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7
Growth hormone stimulates the secretion of insulin-like growth factor binding protein-2 (IGFBP) by monolayer cultures of sheep costal growth plate chondrocytes
Published in Molecular and cellular biochemistry (20-09-1996)“…Using monolayer cultures of costar chondrocytes established from four week old Clun Forest lambs, we have demonstrated that, under serum free conditions the…”
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8
The anabolic actions of growth hormone and thyroxine on protein metabolism in Snell dwarf and normal mice
Published in Journal of endocrinology (01-10-1988)“…The individual effects of GH and thyroxine (T4) on protein metabolism were determined in dwarf and normal mice in vivo. The hormone deficiencies of dwarf mice…”
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9
Potentiation of the somatogenic and lactogenic activity of human growth hormone with monoclonal antibodies
Published in Journal of endocrinology (01-09-1986)“…Monoclonal antibodies of certain epitope specificity have been shown to produce a marked dose-dependent enhancement of the somatogenic and lactogenic activity…”
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10
Monoclonal antibody enhancement of the effects of human growth hormone on growth and body composition in mice
Published in Journal of endocrinology (01-04-1988)“…Dwarf mice were treated for 10 days with phosphate-buffered saline (PBS), human growth hormone (hGH) or hGH with monoclonal antibody EB1 (hGH/MAB-EB1); for…”
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11
Potentiation of growth hormone activity in sheep using monoclonal antibodies
Published in Journal of endocrinology (01-02-1989)“…Monoclonal antibody OA11 was raised against ovine GH; its effects on GH activity were examined in a target species relevant for animal production in vivo. The…”
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12
Monoclonal antibody-mediated enhancement of growth hormone activity in vivo
Published in Journal of endocrinology (01-12-1985)“…This work demonstrates that complexing hGH with monoclonal antibody EBl (MAB-EBl) can produce a striking potentiation of the somatogenic actions of hGH in vivo…”
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13
Actions of growth hormone, prolactin and thyroxine on serum somatomedin-like activity and growth in hypopituitary dwarf mice
Published in Journal of endocrinology (01-08-1977)“…Hypopituitary dwarf mice (Snell's strain) were found to have much reduced levels of serum somatomedin when compared with normal mice (apparently normal members…”
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14
Monoclonal antibodies can enhance the biological activity of thyrotropin
Published in Endocrinology (Philadelphia) (01-02-1987)“…In this work we demonstrate that monoclonal antibodies (MABs) to TSH can enhance the biological actions of TSH in vivo. Hypopituitary Snell dwarf mice were…”
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15
Somatomedin C/insulin-like growth factor I: simplified purification procedure and biological activities of the purified growth factor
Published in Journal of endocrinology (01-07-1986)“…Human somatomedin C has been purified from Cohn fraction IV paste by a simplified procedure using chromatofocusing, hydroxylapatite chromatography and…”
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16
Effect of bovine growth hormone and a partially pure preparation of somatomedin on various growth parameters in hypopituitary dwarf mice
Published in Journal of endocrinology (01-05-1981)“…The growth-promoting effects of a partially purified preparation of somatomedin (12.7 units/mg) were compared with those of various doses of bovine GH (5, 20…”
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17
Fetal rat myoblasts release both rat somatomedin-C (SM-C)/insulin-like growth factor I (IGF I) and multiplication-stimulating activity in vitro: partial characterization and biological activity of myoblast-derived SM-C/IGF I
Published in Endocrinology (Philadelphia) (01-11-1985)“…The relative release of rat somatomedin-C (SM-C)/insulin-like growth factor I (IGF I) and multiplication-stimulating activity (MSA) immunoreactivity and…”
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18
Ovarian-splenic autotransplantation: evidence that oestrogen does not inhibit hepatic somatomedin generation
Published in Journal of endocrinology (01-10-1984)“…This study was designed to test the hypothesis that oestrogens inhibit growth by reducing hepatic somatomedin generation. We have attempted to deliver…”
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19
Antigenic structure of bovine growth hormone: location of a growth enhancing region
Published in Molecular immunology (01-01-1991)“…Site-directed antisera generated by peptide immunization have been used to study the antigenicity of bovine growth hormone (bGH). Prediction of sequential…”
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20
Prolonged oestrogen treatment inhibits growth hormone-induced growth in hypopituitary dwarf mice
Published in Journal of endocrinology (01-03-1983)“…This paper presents an investigation into the effects of prolonged oestrogen treatment (20 days) on basal growth and on growth stimulated by GH in…”
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