Search Results - "Holdaway, K M"

Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancer by Jass, J R, Cottier, D S, Jeevaratnam, P, Pokos, V, Holdaway, K M, Bowden, M L, Van de Water, N S, Browett, P J

“…50 families with a history of colorectal cancer were divided according to whether criteria for hereditary non-polyposis colorectal cancer (HNPCC) were…”
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Inhibition of growth of primary human tumour cell cultures by a 4-anilinoquinazoline inhibitor of the epidermal growth factor receptor family of tyrosine kinases by Baguley, B.C, Marshall, E.S, Holdaway, K.M, Rewcastle, G.W, Denny, W.A

“…The epidermal growth factor receptor (EGFR) is thought to mediate the action of the mitogens EGF and tumour growth factor-α (TGF-α) in a variety of cancers,…”
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Cellular responses to methyl- N-[4-(9-acridinylamino)-2-methoxyphenyl]carbamate hydrochloride, an analogue of amsacrine active against non-proliferating cells by Moreland, N., Finlay, G.J., Dragunow, M., Holdaway, K.M., Baguley, B.C.

“…The acridine derivative m-AMCA (methyl- N-[4-(9-acridinylamino)-2-methoxyphenyl]carbamate hydrochloride), a carbamate analogue of the toposiomerase II poison…”
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Design of DNA intercalators to overcome topoisomerase II-mediated multidrug resistance by Baguley, B C, Holdaway, K M, Fray, L M

“…Murine P388 (P) leukemia cell lines resistant to amsacrine (P/AMSA), dactinomycin (P/DACT), and doxorubicin (P/DOX) were compared with the parental strain in…”
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Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer by Baguley, B.C., Marshall, E.S., Whittaker, J.R., Dotchin, M.C., Nixon, J., McCrystal, M.R., Finlay, G.J., Matthews, J.H.L., Holdaway, K.M., van Zijl, P.

“…Paclitaxel, a drug which stabilises microtubules, demonstrates marked activity against ovarian cancer. We investigated the sensitivity to paclitaxel of tumour…”
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Radiosensitivity of new and established human melanoma cell lines: comparison of [3H]thymidine incorporation and soft agar clonogenic assays by Marshall, E S, Matthews, J H, Shaw, J H, Nixon, J, Tumewu, P, Finlay, G J, Holdaway, K M, Baguley, B C

“…Seven new low-passage melanoma lines were developed in this laboratory from clinical melanoma specimens and characterised for chromosome complement, DNA ploidy…”
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Application of fluorescence in situ hybridisation to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine by Ferguson, Lynnette R., Whiteside, Glenn, Holdaway, Karen M., Baguley, Bruce C.

“…Amsacrine (4′‐(9‐acridinylamino)methanesulphon‐m‐anisidide) is an antileukemic drug which inhibits topoisomerase II (topo II) enzymes. We studied effects of…”
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Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells by FINLAY, G. J, HOLDAWAY, K. M, BAGULEY, B. C

“…The cytotoxicity of a class of compounds related to the topoisomerase-II poison amsacrine was investigated against plateau-phase murine Lewis lung carcinoma…”
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Comparison of the effects of genistein and amsacrine on leukemia cell proliferation by Finlay, G J, Holdaway, K M, Baguley, B C

“…Genistein is an inhibitor of the enzymes protein tyrosine kinase and topoisomerase-II. It induces G2-phase arrest in human Jurkat and murine P388 leukemia…”
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Cytokinetic differences in the action of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide as compared with that of amsacrine and doxorubicin by HALDANE, A, HOLDAWAY, K. M, FINLAY, G. J, BAGULEY, B. C

“…N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide dihydrochloride (DACA) is a topoisomerase II-directed DNA intercalator with high experimental solid-tumour…”
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Anticancer drug sensitivity profiles of new and established melanoma cell lines by Marshall, E S, Holdaway, K M, Shaw, J H, Finlay, G J, Matthews, J H, Baguley, B C

“…Metastatic melanoma is notable for its resistance to chemotherapy, and methods for determining resistance in cultures would be advantageous. We investigated…”
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Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism by Baguley, B C, Holdaway, K M, Thomsen, L L, Zhuang, L, Zwi, L J

“…Vinblastine or colchicine, administered intraperitoneally to B6D2F1 mice with advanced subcutaneous colon 38 tumours, induced substantial tumour growth delays…”
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Radiation-induced cell cycle delays and p53 status of early passage melanoma cell lines by Parmar, J, Marshall, E S, Charters, G A, Holdaway, K M, Shelling, A N, Baguley, B C

“…Cell cultures exposed to DNA-damaging agents such as gamma radiation respond by arresting at cell cycle checkpoints, and the p53 tumor suppressor protein is…”
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Annexin‐V and TUNEL use in monitoring the progression of apoptosis in plants by O'Brien, Iona E. W., Reutelingsperger, Chris P. M., Holdaway, Karen M.

“…An early indicator of apoptosis in mammalian cells is the loss of the phospholipid membrane asymmetry of the cell. This results in exposure of…”
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The role of immune effector cells in flavone acetic acid-induced injury to tumor cells in EMT6 spheroids by Zwi, L J, Baguley, B C, Gavin, J B, Holdaway, K M, Wilson, W R

“…Inhibition of tumor blood flow appears to a major antitumor mechanism of flavone acetic acid (FAA), although non-ischemic processes may also be a significant…”
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Relationship of cell cycle parameters to in vitro and in vivo chemosensitivity for a series of Lewis lung carcinoma lines by Holdaway, K M, Finlay, G J, Baguley, B C

“…The sensitivity of three Lewis lung carcinoma sublines, which grow in culture and in vivo, and vary in in vivo drug sensitivity, have been compared using…”
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