Search Results - "Holcomb, Erin"

A forced marriage of IL-2 and PD-1 antibody nurtures tumor-infiltrating T cells by Holcomb, Erin A, Zou, Weiping

“…IL-2 is a pleiotropic cytokine. In this issue of the JCI, Ren et al. report on the development of a low-affinity IL-2 paired with anti-PD-1 (PD-1-laIL-2) that…”
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Mechanisms of Immunopathogenesis in Cutaneous Leishmaniasis And Post Kala-azar Dermal Leishmaniasis (PKDL) by Volpedo, Greta, Pacheco-Fernandez, Thalia, Holcomb, Erin A, Cipriano, Natalie, Cox, Blake, Satoskar, Abhay R

“…Leishmaniasis is a neglected tropical disease that affects 12 million people worldwide. The disease has high morbidity and mortality rates and is prevalent in…”
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High-content CRISPR screening in tumor immunology by Holcomb, Erin A, Pearson, Ashley N, Jungles, Kassidy M, Tate, Akshay, James, Jadyn, Jiang, Long, Huber, Amanda K, Green, Michael D

“…CRISPR screening is a powerful tool that links specific genetic alterations to corresponding phenotypes, thus allowing for high-throughput identification of…”
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Ibrutinib treatment inhibits breast cancer progression and metastasis by inducing conversion of myeloid-derived suppressor cells to dendritic cells by Varikuti, Sanjay, Singh, Bhawana, Volpedo, Greta, Ahirwar, Dinesh K., Jha, Bijay K., Saljoughian, Noushin, Viana, Agostinho G., Verma, Chaitenya, Hamza, Omar, Halsey, Gregory, Holcomb, Erin A., Maryala, Ritvik J., Oghumu, Steve, Ganju, Ramesh K., Satoskar, Abhay R.

“…Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) and interleukin-2-inducible kinase (ITK) inhibitor used for treating chronic lymphocytic leukaemia…”
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From infection to vaccination: reviewing the global burden, history of vaccine development, and recurring challenges in global leishmaniasis protection by Volpedo, Greta, Huston, Ryan H, Holcomb, Erin A, Pacheco-Fernandez, Thalia, Gannavaram, Sreenivas, Bhattacharya, Parna, Nakhasi, Hira L, Satoskar, Abhay R

“…Leishmaniasis is a major public health problem and the second most lethal parasitic disease in the world due to the lack of effective treatments and vaccines…”
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Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer by Jungles, Kassidy M., Holcomb, Erin A., Pearson, Ashley N., Jungles, Kalli R., Bishop, Caroline R., Pierce, Lori J., Green, Michael D., Speers, Corey W.

“…Breast cancer is the most prevalent non-skin cancer diagnosed in females and developing novel therapeutic strategies to improve patient outcomes is crucial…”
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Older age and online health information search behaviors: The mediating influence of executive functions by Kordovski, Victoria M., Tierney, Savanna M., Rahman, Samina, Medina, Luis D., Babicz, Michelle A., Yoshida, Hanako, Holcomb, Erin M., Cushman, Clint, Woods, Steven Paul

“…Searching the internet for health-related information is a complex and dynamic goal-oriented process that ostensibly places demands on executive functions,…”
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Incidence, Characterization, and Predictors of Sleep Apnea in Consecutive Brain Injury Rehabilitation Admissions by Holcomb, Erin M, Schwartz, Daniel J, McCarthy, Marissa, Thomas, Bryan, Barnett, Scott D, Nakase-Richardson, Risa

“…To prospectively examine the incidence and risk factors for sleep apnea in consecutive brain injury rehabilitation admissions. Inpatient neurorehabilitation…”
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The Relationship Between Sleep-Wake Cycle Disturbance and Trajectory of Cognitive Recovery During Acute Traumatic Brain Injury by Holcomb, Erin M, Towns, Stephanie, Kamper, Joel E, Barnett, Scott D, Sherer, Mark, Evans, Clea, Nakase-Richardson, Risa

“…Following traumatic brain injury, both sleep dysfunction and cognitive impairment are common. Unfortunately, little is known regarding the potential…”
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Impact of immune tolerance mechanisms on the efficacy of immunotherapy in primary and secondary liver cancers by Sankar, Kamya, Pearson, Ashley N., Worlikar, Tejaswi, Perricone, Matthew D., Holcomb, Erin A., Mendiratta-Lala, Mishal, Xu, Zhen, Bhowmick, Neil, Green, Michael D.

“…The liver is a functionally unique organ with an immunosuppressive microenvironment. The liver is the sixth most common site of primary cancer in humans and is…”
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Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis by Volpedo, Greta, Pacheco-Fernandez, Thalia, Holcomb, Erin A., Zhang, Wen-Wei, Lypaczewski, Patrick, Cox, Blake, Fultz, Rebecca, Mishan, Chelsea, Verma, Chaitenya, Huston, Ryan H., Wharton, Abigail R., Dey, Ranadhir, Karmakar, Subir, Oghumu, Steve, Hamano, Shinjiro, Gannavaram, Sreenivas, Nakhasi, Hira L., Matlashewski, Greg, Satoskar, Abhay R.

“…Leishmaniasis is a neglected protozoan disease affecting over 12 million people globally with no approved vaccines for human use. New World cutaneous…”
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Comorbid Disease in Persons With Traumatic Brain Injury: Descriptive Findings Using the Modified Cumulative Illness Rating Scale by Holcomb, Erin M., MA, Millis, Scott R., PhD, Hanks, Robin A., PhD

“…Abstract Holcomb EM, Millis SR, Hanks RA. Comorbid disease in persons with traumatic brain injury: descriptive findings using the Modified Cumulative Illness…”
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Potentiating the radiation-induced type I interferon antitumoral immune response by ATM inhibition in pancreatic cancer by Zhang, Qiang, Jiang, Long, Wang, Weiwei, Huber, Amanda K, Valvo, Victoria M, Jungles, Kassidy M, Holcomb, Erin A, Pearson, Ashley N, The, Stephanie, Wang, Zhuwen, Parsels, Leslie A, Parsels, Joshua D, Wahl, Daniel R, Rao, Arvind, Sahai, Vaibhav, Lawrence, Theodore S, Green, Michael D, Morgan, Meredith A

“…Radiotherapy induces a type I interferon-mediated (T1IFN-mediated) antitumoral immune response that we hypothesized could be potentiated by a first-in-class…”
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SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma by Elaimy, Ameer L, El-Derany, Marwa O, James, Jadyn, Wang, Zhuwen, Pearson, Ashley N, Holcomb, Erin A, Huber, Amanda K, Gijón, Miguel A, Bell, Hannah N, Sanghvi, Viraj R, Frankel, Timothy L, Su, Grace L, Tapper, Elliot B, Tai, Andrew W, Ramnath, Nithya, Centonze, Christopher P, Dobrosotskaya, Irina, Moeller, Julie A, Bryant, Alex K, Elliott, David A, Choi, Enid, Evans, Joseph R, Cuneo, Kyle C, FitzGerald, Thomas J, Wahl, Daniel R, Morgan, Meredith A, Chang, Daniel T, Wicha, Max S, Lawrence, Theodore S, Shah, Yatrik M, Green, Michael D

“…End stage liver disease is marked by portal hypertension, systemic elevations in ammonia, and development of hepatocellular carcinoma (HCC). While these…”
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Embedded Measures of Performance Validity in the Rey Complex Figure Test in a Clinical Sample of Veterans by Sugarman, Michael A., Holcomb, Erin M., Axelrod, Bradley N., Meyers, John E., Liethen, Philip C.

“…The purpose of this study was to determine how well scores from the Rey Complex Figure Test (RCFT) could serve as embedded measures of performance validity in…”
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Implementation of Actigraphy in Acute Traumatic Brain Injury (TBI) Neurorehabilitation Admissions: A Veterans Administration TBI Model Systems Feasibility Study by Towns, Stephanie J., PsyD, Zeitzer, Jamie, PhD, Kamper, Joel, PhD, Holcomb, Erin, PhD, Silva, Marc A., PhD, Schwartz, Daniel J., MD, Nakase-Richardson, Risa, PhD

“…Abstract Background Sleep problems and disorders are prevalent in patients with traumatic brain injury (TBI) and are associated with negative outcomes…”
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Hemispheric processing of Chinese hànzì and English words: A lateralized lexical decision study by Whitman, Douglas, Wurm, Lee, Holcomb, Erin, Wang, Zhenni, Liao, Jo Fu, Van Dyke, Sarah A.

“…We presented orthographic English words or Chinese logographic hànzì primes to either the left or right visual fields followed by a semantically related target…”
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A forced marriage of IL-2 and PD-1 antibody nurtures tumor-infiltrating T cells by Holcomb, Erin A, Zou, Weiping

“…IL-2 is a pleiotropic cytokine. In this issue of theJCI, Ren et al. report on the development of a low-affinity IL-2 paired with anti-PD-1 (PD-1-laIL-2) that…”
Get full text

A forced marriage of IL-2 and PD-1 antibody nurtures tumor-infiltrating T cells by Holcomb, Erin A, Zou, Weiping

“…IL-2 is a pleiotropic cytokine. In this issue of theJCI, Ren et al. report on the development of a low-affinity IL-2 paired with anti-PD-1 (PD-1-laIL-2) that…”
Get full text

Liver metastases reprogram neutrophils to potentiate cancer progression by Pearson, Ashley, Holcomb, Erin, James, Jadyn, Wang, Zhuwen, Kyi, Justine, Huber, Amanda, Green, Michael

“…Liver metastases are associated with poor overall survival and increased disease progression, regardless of primary tumor type. Liver metastases suppress…”
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