Search Results - "Holcik, M."

IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1 by Faye, M D, Beug, S T, Graber, T E, Earl, N, Xiang, X, Wild, B, Langlois, S, Michaud, J, Cowan, K N, Korneluk, R G, Holcik, M

“…Rhabdomyosarcoma (RMS), a neoplasm characterised by undifferentiated myoblasts, is the most common soft tissue tumour of childhood. Although aggressive…”
Get full text

For IRES trans-acting factors, it is all about location by Lewis, S M, Holcik, M

“…The translation of many proteins involved in transcription, cell cycle progression, apoptosis and cell survival is mediated by internal ribosome entry sites…”
Get full text

Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta by Brett, K.E, Ferraro, Z.M, Holcik, M, Adamo, K.B

“…Abstract Introduction Adequate nutrient delivery to the fetus is essential for optimal growth. Differences in prenatal physical activity level and diet quality…”
Get full text

Functional Characterization of the X-Linked Inhibitor of Apoptosis (XIAP) Internal Ribosome Entry Site Element: Role of La Autoantigen in XIAP Translation by Holcik, Martin, Korneluk, Robert G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2 by Graber, T E, Holcik, M

Get full text

Translation control in apoptosis by Liwak, U, Faye, M D, Holcik, M

“…Regulation of protein synthesis, although known for many decades, has only recently begun to be recognized as a critical control mechanism for the maintenance…”
Get more information

NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response by Graber, T E, Baird, S D, Kao, P N, Mathews, M B, Holcik, M

“…Expression of the cellular inhibitor of apoptosis protein 1 (cIAP1) is unexpectedly repressed at the level of translation under normal physiological conditions…”
Get full text

Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein by Courteau, L, Crasto, J, Hassanzadeh, G, Baird, S D, Hodgins, J, Liwak-Muir, U, Fung, G, Luo, H, Stojdl, D F, Screaton, R A, Holcik, M

“…Subcellular localization of RNA-binding proteins is a key determinant of their ability to control RNA metabolism and cellular stress response. Using an…”
Get full text

Internal ribosome initiation of translation and the control of cell death by Holcik, Martin, Sonenberg, Nahum, Korneluk, Robert G.

“…The majority of cellular stresses lead to the inhibition of cap-dependent translation. Some mRNAs, however, are translated by a cap-independent mechanism,…”
Get full text

hnRNP A1 regulates UV-induced NF-κB signalling through destabilization of cIAP1 mRNA by Zhao, T T, Graber, T E, Jordan, L E, Cloutier, M, Lewis, S M, Goulet, I, Côté, J, Holcik, M

“…cIAP1 is an important member of the inhibitor of apoptosis family of proteins and is involved in the regulation of the NF- κ B-signalling pathway downstream of…”
Get full text

The utrophin A 5′-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2 by Miura, P., Coriati, A., Bélanger, G., De Repentigny, Y., Lee, J., Kothary, R., Holcik, M., Jasmin, B.J.

“…The molecular mechanisms regulating expression of utrophin A are of therapeutic interest since upregulating its expression at the sarcolemma can compensate for…”
Get full text

RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation by Durie, D, Lewis, S M, Liwak, U, Kisilewicz, M, Gorospe, M, Holcik, M

“…Expression of the intrinsic cellular caspase inhibitor XIAP is regulated primarily at the level of protein synthesis. The 5′ untranslated region harbours an…”
Get full text

T.P.8 Induction of SMN protein by combination of STAT5 and p38 kinase activating, clinic ready compounds for the treatment of SMA by Farooq, F.T, MacKenzie, D, Shamim, F, Holcik, M, MacKenzie, A

“…Abstract Spinal muscle atrophy (SMA) is an autosomal recessive neurodegenerative disease which is characterized by the loss of α motor neurons resulting in…”
Get full text

Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination by Hebb, ALO, Moore, CS, Bhan, V, Campbell, T, Fisk, JD, Robertson, HA, Thorne, M, Lacasse, E, Holcik, M, Gillard, J, Crocker, SJ, Robertson, GS

“…A failure of autoreactive T cells to undergo apoptosis may contribute to the pathogenesis of multiple sclerosis (MS). The role of the inhibitor of apoptosis…”
Get full text

Posttranscriptional Regulation of Collagen α1(I) mRNA in Hepatic Stellate Cells by Stefanovic, B., Hellerbrand, C., Holcik, M., Briendl, M., Aliebhaber, S., Brenner, D. A.

“…The hepatic stellate cell (HSC) is the primary cell responsible for the dramatic increase in the synthesis of type I collagen in the cirrhotic liver. Quiescent…”
Get full text

The translation of an antiapoptotic protein HIAP2 is regulated by an upstream open reading frame by Warnakulasuriyarachchi, D, Ungureanu, N H, Holcík, M

“…HIAP2 is a multifunctional protein that is critically involved in the regulation of cell survival and apoptosis. Here, we show that HIAP2 5' untranslated…”
Get full text

Apoptosis: don't get mad, get even by Holcik, Martin

Get full text

Apoptosis: don't get mad, get even by Holcik, Martin

Get full text

Translational control in stress and apoptosis by Holcik, Martin, Sonenberg, Nahum

“…Cells respond to stress stimuli through coordinated changes in gene expression. The regulation of translation is often used under these circumstances because…”
Get full text

Endogenous expression of inhibitor of apoptosis proteins in facial motoneurons of neonatal and adult rats following axotomy by Mcphail, L.T, Vanderluit, J.L, Mcbride, C.B, Oschipok, L.W, Crocker, S.J, Xu, D, Thompson, C.S, Liston, P, Holcik, M, Robertson, G.S, Tetzlaff, W

“…The inhibitor of apoptosis protein family members inhibit cell death resulting from a variety of apoptotic stimuli. However, the endogenous expression of…”
Get full text