Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prunífera against Triton WR-1339 and hyperlipidemic diet in mice

[Display omitted] •P-Methoxycinnamic Diester (PCO-C) was extracted from the waxy powder of the leaves of carnauba plants.•The P-Methoxycinnamic Diester (PCO-C) exhibited a high hypolipidemic potential.•The PCO-C promoted a hepatoprotective effect with fat reduction in the liver. Carnauba wax is extr...

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Published in:	Environmental toxicology and pharmacology Vol. 56; pp. 198 - 203
Main Authors:	Filho, A.C.V.A., Rodrigues, P.A.S., Benjamin, S.R., Paim, R.T.T., Holanda, M.O., Silva, J.Y.G., Milo, T.S., Vieira, I.G.P., Queiroz, M.G.R., Guedes, M.I.F.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-12-2017 Elsevier Science Ltd
Subjects:	Animal models Animals Arecaceae - chemistry Arteriosclerosis Atherosclerosis Carnauba wax Cholesterol Cholesterol - blood Cinnamic acid esters Copernicia Diesters Diet Diet, High-Fat - adverse effects Disease Models, Animal Dose-Response Relationship, Drug Dyslipidemia Dyslipidemias - chemically induced Dyslipidemias - drug therapy Esters Esters - administration & dosage Esters - chemistry Esters - pharmacology Fatty liver Hyperlipidemia Hyperlipidemic diet Hypolipidemic activity Lipids Male Mice Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Plasma levels Rodents Steatosis Studies Triglycerides Triglycerides - blood Triton Triton WR-1339 Waxes - chemistry Waxes - pharmacology Dyslipidemia S.D TC CVD SD TG PC PCO-C Carnauba wax ANOVA LDL NC GEMF Hyperlipidemic diet STZ SIMV Cinnamic acid esters HD Triton WR-1339 HE MCT
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Summary:	[Display omitted] •P-Methoxycinnamic Diester (PCO-C) was extracted from the waxy powder of the leaves of carnauba plants.•The P-Methoxycinnamic Diester (PCO-C) exhibited a high hypolipidemic potential.•The PCO-C promoted a hepatoprotective effect with fat reduction in the liver. Carnauba wax is extracted from the leaves of the Copernicia prunífera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia prunífera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and triglycerides were significantly reduced plasma levels in PCO-C at the dose of 100mg/kg in a model of acute and chronic dyslipidemia. Histological studies showed that PCO-C has no hepatotoxic effect and reduces hepatic steatosis in animals that consumed hyperlipidemic ration. Thus, it was concluded that PCO-C isolated from Copernicia Prunifera was effective in reducing total cholesterol and triglyceride levels in both dyslipidemia induction models. The finding indicates that PCO-C might be beneficial in treatment of hyperlipidemia and atherosclerosis.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2017.09.015