Phytopharmacological aspects of Mimosa tenuiflora (Willd.) poir.: a systematic review of preclinical data

Mimosa tenuiflora (Willd.) Poir. is a native species of tropical regions with a diverse therapeutic potential due to the presence of various metabolites in its botanical composition. This review provides updated information on the phytochemistry and pharmacological activities of M. tenuiflora . The...

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Bibliographic Details
Published in:	Phytochemistry reviews Vol. 23; no. 4; pp. 1183 - 1203
Main Authors:	Silva, Emerson de Oliveira, de Souza, Myla Lôbo, de Souza, Nathália Andrezza Carvalho, de Melo, Demis Ferreira, da Costa, Lucas Amadeu Gonzaga, Holanda, Bruna Fernanda de Lima Arruda, Nishimura, Rodolfo Hideki Vicente, Rolim, Larissa Araújo, Rolim Neto, Pedro José
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-08-2024 Springer Nature B.V
Subjects:	Antidepressants Antiparasitic agents Bioactive compounds Biochemistry Biological activity Biological effects Biomedical and Life Sciences Chemical activity Chemical compounds Chemistry/Food Science Clinical trials Flavonoids In vivo methods and tests Indigenous species Life Sciences Metabolites Mimosa tenuiflora Organic Chemistry Pain perception Pharmaceuticals Pharmacology Plant extracts Plant Genetics and Genomics Plant Sciences Reviews Secondary metabolites Tropical environment Tropical environments Pharmacological activities Ethnopharmacology Secondary metabolites
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Summary:	Mimosa tenuiflora (Willd.) Poir. is a native species of tropical regions with a diverse therapeutic potential due to the presence of various metabolites in its botanical composition. This review provides updated information on the phytochemistry and pharmacological activities of M. tenuiflora . The studies used in this review were obtained from specialized databases (PubMed, Scielo, Science Direct, Web of Science, Springer, and Scopus) using the keywords: Mimosa tenuiflora , phytochemistry, and pharmacological activity. The selected articles were analyzed by year of publication, country where the research was conducted, isolated chemical compounds reported, and biological activities evaluated. The selected articles were peer-reviewed in the following order: title, abstract, and full text. While the majority of studies involving M. tenuiflora are still situated in Brazil and Mexico, some research is being conducted outside of Latin America. In vitro and in vivo studies report various pharmacological activities for M. tenuiflora , such as antimicrobial, antiparasitic, antioxidant, anti-inflammatory, antinociceptive, and antidepressant effects. These diverse activities are attributed to the presence of flavonoids and alkaloids, identified as the main classes of secondary metabolites in M. tenuiflora . The effective doses for biological activities vary according to the plant part used and the type of extracting solvent. Additionally, the isolation and concentration of the bioactive compound optimizes and reduces the potential effective therapeutic dose. The arsenal of bioactive compounds provides versatility for potential therapeutic uses of M. tenuiflora . Despite its therapeutic potential, clinical trials are still lacking, and preclinical studies remain limited and heterogeneous, representing an opportunity for further pharmacological investigation.
ISSN:	1568-7767 1572-980X
DOI:	10.1007/s11101-024-09919-x