MRI-guided focused ultrasound: methodology and applications

Focused ultrasound is very well suited for inducing noninvasive local hyperthermia. Since magnetic resonance imaging (MRI) may be employed to obtain real-time temperature maps noninvasively the combination of these two technologies offers great advantages specifically aimed toward oncological studie...

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Bibliographic Details
Published in:	IEEE transactions on medical imaging Vol. 25; no. 6; pp. 723 - 731
Main Authors:	Hokland, S.L., Pedersen, M., Salomir, R., Quesson, B., Stodkilde-Jorgensen, H., Moonen, C.T.W.
Format:	Journal Article
Language:	English
Published:	United States IEEE 01-06-2006 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:	Automatic temperature control Biomedical imaging Clinical Trials as Topic - trends Drug delivery focused ultrasound Focusing high-intensity focused ultrasound Humans Hyperthermia Magnetic resonance imaging Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - trends Medical diagnostic imaging Medical treatment MRI thermometry Pharmaceutical technology Practice Patterns, Physicians' - trends Temperature control Therapy, Computer-Assisted - instrumentation Therapy, Computer-Assisted - methods Therapy, Computer-Assisted - trends thermal ablation Thermography - instrumentation Thermography - methods Thermography - trends thermotherapy Ultrasonic imaging Ultrasonic Therapy - instrumentation Ultrasonic Therapy - methods Ultrasonic Therapy - trends
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Summary:	Focused ultrasound is very well suited for inducing noninvasive local hyperthermia. Since magnetic resonance imaging (MRI) may be employed to obtain real-time temperature maps noninvasively the combination of these two technologies offers great advantages specifically aimed toward oncological studies. Real-time identification of the target region and accurate control of the temperature evolution during the treatment has now become possible. Thermal ablation of pathological tissue, local drug delivery using thermosensitive micro-carriers and controlled transgene expression using thermosensitive promoters have recently been demonstrated with this unique technology. Based on these experiments combined focused ultrasound and MRI thermometry holds promise for future oncological diagnostics and treatment. In this paper, we review some of the recent methodological developments as well as experimental and first clinical studies using this approach
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Feature-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0278-0062 1558-254X
DOI:	10.1109/TMI.2006.873296