Search Results - "Hoke, David E."

LipL32 Is an Extracellular Matrix-Interacting Protein of Leptospira spp. and Pseudoalteromonas tunicata by HOKE, David E, EGAN, Suhelen, CULLEN, Paul A, ADLER, Ben

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity by Le, Sarah N, Porebski, Benjamin T, McCoey, Julia, Fodor, James, Riley, Blake, Godlewska, Marlena, Góra, Monika, Czarnocka, Barbara, Banga, J Paul, Hoke, David E, Kass, Itamar, Buckle, Ashley M

“…Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto's disease--the most common organ-specific…”
Get full text

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif by Chen, Xingchen, Riley, Blake T, de Veer, Simon J, Hoke, David E, Van Haeften, Jessica, Leahy, Darren, Swedberg, Joakim E, Brattsand, Maria, Hartfield, Perry J, Buckle, Ashley M, Harris, Jonathan M

“…Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski…”
Get full text

Major Surface Protein LipL32 Is Not Required for Either Acute or Chronic Infection with Leptospira interrogans by Murray, Gerald L, Srikram, Amporn, Hoke, David E, Wunder, Elsio A. Jr, Henry, Rebekah, Lo, Miranda, Zhang, Kunkun, Sermswan, Rasana W, Ko, Albert I, Adler, Ben

“…Leptospira interrogans is responsible for leptospirosis, a zoonosis of worldwide distribution. LipL32 is the major outer membrane protein of pathogenic…”
Get full text

An ortholog of the Leptospira interrogans lipoprotein LipL32 aids in the colonization of Pseudoalteromonas tunicata to host surfaces by Gardiner, Melissa, Hoke, David E, Egan, Suhelen

“…The bacterium Pseudoalteromonas tunicata is a common surface colonizer of marine eukaryotes, including the macroalga Ulva australis.Genomic analysis of P…”
Get full text

Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis by Kass, Itamar, Hoke, David E, Costa, Mauricio G S, Reboul, Cyril F, Porebski, Benjamin T, Cowieson, Nathan P, Leh, Hervé, Pennacchietti, Eugenia, McCoey, Julia, Kleifeld, Oded, Borri Voltattorni, Carla, Langley, David, Roome, Brendan, Mackay, Ian R, Christ, Daniel, Perahia, David, Buckle, Malcolm, Paiardini, Alessandro, De Biase, Daniela, Buckle, Ashley M

“…The human neuroendocrine enzyme glutamate decarboxylase (GAD) catalyses the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) using…”
Get full text

Smoothing a rugged protein folding landscape by sequence-based redesign by Porebski, Benjamin T., Keleher, Shani, Hollins, Jeffrey J., Nickson, Adrian A., Marijanovic, Emilia M., Borg, Natalie A., Costa, Mauricio G. S., Pearce, Mary A., Dai, Weiwen, Zhu, Liguang, Irving, James A., Hoke, David E., Kass, Itamar, Whisstock, James C., Bottomley, Stephen P., Webb, Geoffrey I., McGowan, Sheena, Buckle, Ashley M.

“…The rugged folding landscapes of functional proteins puts them at risk of misfolding and aggregation. Serine protease inhibitors, or serpins, are paradigms for…”
Get full text

Leptospiral LruA Is Required for Virulence and Modulates an Interaction with Mammalian Apolipoprotein AI by Zhang, Kunkun, Murray, Gerald L, Seemann, Torsten, Srikram, Amporn, Bartpho, Thanatchaporn, Sermswan, Rasana W, Adler, Ben, Hoke, David E

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE by Hatfaludi, Tamás, Al-Hasani, Keith, Gong, Lan, Boyce, John D, Ford, Mark, Wilkie, Ian W, Quinsey, Noelene, Dunstone, Michelle A, Hoke, David E, Adler, Ben

“…There is a strong need for a recombinant subunit vaccine against fowl cholera. We used a reverse vaccinology approach to identify putative secreted or cell…”
Get full text

Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation by Chan, Jun Yong, Zhang, Huacheng, Nolvachai, Yada, Hu, Yaoxin, Zhu, Haijin, Forsyth, Maria, Gu, Qinfen, Hoke, David E., Zhang, Xiwang, Marriot, Philip J., Wang, Huanting

“…Homochiral metal–organic frameworks (MOFs) have gained much attention because of their chiral properties and disposition for chiral separation. However, the…”
Get full text

An analysis of the cross-reactivity of autoantibodies to GAD65 and GAD67 in diabetes by Jayakrishnan, Bindu, Hoke, David E, Langendorf, Christopher G, Buckle, Ashley M, Rowley, Merrill J

“…Autoantibodies to GAD65 (anti-GAD65) are present in the sera of 70-80% of patients with type 1 diabetes (T1D), but antibodies to the structurally similar 67…”
Get full text

Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein by Lawson, Victoria A, Lumicisi, Brooke, Welton, Jeremy, Machalek, Dorothy, Gouramanis, Katrina, Klemm, Helen M, Stewart, James D, Masters, Colin L, Hoke, David E, Collins, Steven J, Hill, Andrew F

“…The accumulation of protease resistant conformers of the prion protein (PrP(res)) is a key pathological feature of prion diseases. Polyanions, including RNA…”
Get full text

Crystal Structure of LipL32, the Most Abundant Surface Protein of Pathogenic Leptospira spp by Vivian, Julian P., Beddoe, Travis, McAlister, Adrian D., Wilce, Matthew C.J., Zaker-Tabrizi, Leyla, Troy, Sally, Byres, Emma, Hoke, David E., Cullen, Paul A., Lo, Miranda, Murray, Gerald L., Adler, Ben, Rossjohn, Jamie

“…Spirochetes of the genus Leptospira cause leptospirosis in humans and animals worldwide. Proteins exposed on the bacterial cell surface are implicated in the…”
Get full text

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate by Ho, Michael, Hoke, David E., Chua, Yee Jia, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin L., White, Anthony R., Evin, Geneviève

“…Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative…”
Get full text

Thyroid Peroxidase as an Autoantigen in Hashimoto's Disease: Structure, Function, and Antigenicity by Williams, Daniel E, Le, Sarah N, Godlewska, Marlena, Hoke, David E, Buckle, Ashley M

“…Human thyroid peroxidase (TPO), is an important enzyme responsible for the biosynthesis of thyroid hormones and is a major autoantigen in autoimmune thyroid…”
Get more information

Reactive centre loop dynamics and serpin specificity by Marijanovic, Emilia M., Fodor, James, Riley, Blake T., Porebski, Benjamin T., Costa, Mauricio G. S., Kass, Itamar, Hoke, David E., McGowan, Sheena, Buckle, Ashley M.

“…Serine proteinase inhibitors (serpins), typically fold to a metastable native state and undergo a major conformational change in order to inhibit target…”
Get full text

Mutational and biophysical robustness in a prestabilized monobody by Chandler, Peter G., Tan, Li Lynn, Porebski, Benjamin T., Green, James S., Riley, Blake T., Broendum, Sebastian S., Hoke, David E., Falconer, Robert J., Munro, Trent P., Buckle, Malcolm, Jackson, Colin J., Buckle, Ashley M.

“…The fibronectin type III (FN3) monobody domain is a promising non-antibody scaffold, which features a less complex architecture than an antibody while…”
Get full text

Structural Studies of Thyroid Peroxidase Show the Monomer Interacting With Autoantibodies in Thyroid Autoimmune Disease by Williams, Daniel E, Le, Sarah N, Hoke, David E, Chandler, Peter G, Gora, Monika, Godlewska, Marlena, Banga, J Paul, Buckle, Ashley M

“…Thyroid peroxidase (TPO) is a critical membrane-bound enzyme involved in the biosynthesis of multiple thyroid hormones, and is a major autoantigen in…”
Get full text

KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors by Riley, Blake T, Ilyichova, Olga, de Veer, Simon J, Swedberg, Joakim E, Wilson, Emily, Hoke, David E, Harris, Jonathan M, Buckle, Ashley M

“…Sunflower trypsin inhibitor (SFTI-1) is a 14 amino acid serine protease inhibitor. The dual antiparallel β-sheet arrangement of SFTI-1 is stabilized by an…”
Get full text

Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain by Porebski, Benjamin T., Nickson, Adrian A., Hoke, David E., Hunter, Morag R., Zhu, Liguang, McGowan, Sheena, Webb, Geoffrey I., Buckle, Ashley M.

“…Consensus protein design is a rapid and reliable technique for the improvement of protein stability, which relies on the use of homologous protein sequences…”
Get full text