Search Results - "Hohn, Michael J."

Rewiring Translation for Elongation Factor Tu-Dependent Selenocysteine Incorporation by Aldag, Caroline, Bröcker, Markus J., Hohn, Michael J., Prat, Laure, Hammond, Gifty, Plummer, Abigail, Söll, Dieter

“…Enjoying UTu in concert: A synthetic tRNA (tRNAUTu) was used as a substrate for three E. coli proteins: seryl‐tRNA synthetase (SerRS) forming Ser‐tRNAUTu,…”
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RNA-Dependent Conversion of Phosphoserine forms Selenocysteine in Eukaryotes and Archaea by Yuan, Jing, Palioura, Sotiria, Salazar, Juan Carlos, Su, Dan, O'Donoghue, Patrick, Hohn, Michael J., Cardoso, Alexander Machado, Whitman, William B., Söll, Dieter

“…The trace element selenium is found in proteins as selenocysteine (Sec), the 21st amino acid to participate in ribosome-mediated translation. The substrate for…”
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A new phylum of Archaea represented by a nanosized hyperthermophilic symbiont by Stetter, Karl O, Huber, Harald, Hohn, Michael J, Rachel, Reinhard, Fuchs, Tanja, Wimmer, Verena C

“…According to small subunit ribosomal RNA (ss rRNA) sequence comparisons all known Archaea belong to the phyla Crenarchaeota, Euryarchaeota, and-indicated only…”
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Selenomodification of tRNA in archaea requires a bipartite rhodanese enzyme by Su, Dan, Ojo, Temitope T., Söll, Dieter, Hohn, Michael J.

“…► A bipartite archaeal tRNA 2-selenouridine synthase (SelU) was identified in silico. ► Both proteins are required to catalyze tRNA selenation in vivo and in…”
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The Genome of Nanoarchaeum equitans: Insights into Early Archaeal Evolution and Derived Parasitism by Waters, Elizabeth, Hohn, Michael J., Ahel, Ivan, Graham, David E., Adams, Mark D., Barnstead, Mary, Beeson, Karen Y., Bibbs, Lisa, Bolanos, Randall, Keller, Martin, Kretz, Keith, Lin, Xiaoying, Mathur, Eric, Ni, Jingwei, Podar, Mircea, Richardson, Toby, Sutton, Granger G., Simon, Melvin, Söll, Dieter, Stetter, Karl O., Short, Jay M., Noordewier, Michiel

“…The hyperthermophile Nanoarchaeum equitans is an obligate symbiont growing in coculture with the crenarchaeon Ignicoccus. Ribosomal protein and rRNA-based…”
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Ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea by Liu, Yuchen, Nakamura, Akiyoshi, Nakazawa, Yuto, Asano, Nozomi, Ford, Kara A., Hohn, Michael J., Tanaka, Isao, Yao, Min, Söll, Dieter

“…Methanogenic archaea lack cysteinyl-tRNA synthetase; they synthesize Cys-tRNA and cysteine in a tRNA-dependent manner. Two enzymes are required:…”
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Genetic analysis of selenocysteine biosynthesis in the archaeon Methanococcus maripaludis by Hohn, Michael J., Palioura, Sotiria, Su, Dan, Yuan, Jing, Söll, Dieter

“…Summary In Archaea selenocysteine (Sec) is synthesized in three steps. First seryl‐tRNA synthetase acylates tRNASec with serine to generate Ser‐tRNASec. Then…”
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Ignicoccus hospitalis sp. nov., the host of 'Nanoarchaeum equitans' by Paper, Walter, Jahn, Ulrike, Hohn, Michael J, Kronner, Michaela, Nather, Daniela J, Burghardt, Tillmann, Rachel, Reinhard, Stetter, Karl O, Huber, Harald

“…Lehrstuhl für Mikrobiologie und Archaeenzentrum, Universität Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany Correspondence Harald Huber…”
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Emergence of the Universal Genetic Code Imprinted in an RNA Record by Hohn, Michael J., Park, Hee-Sung, O'Donoghue, Patrick, Schnitzbauer, Michael, Söll, Dieter

“…The molecular basis of the genetic code manifests itself in the interaction of the aminoacyl-tRNA synthetases and their cognate tRNAs. The fundamental…”
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Expanding the Genetic Code of Escherichia coli with Phosphoserine by Park, Hee-Sung, Hohn, Michael J., Umehara, Takuya, Guo, Li-Tao, Osborne, Edith M., Benner, Jack, Noren, Christopher J., Rinehart, Jesse, Söll, Dieter

“…O-Phosphoserine (Sep), the most abundant phosphoamino acid in the eukaryotic phosphoproteome, is not encoded in the genetic code, but synthesized…”
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Inhibition of Myc transcriptional activity by a mini‐protein based upon Mxd1 by Demma, Mark J., Hohn, Michael J., Sun, Angie, Mapelli, Claudio, Hall, Brian, Walji, Abbas, O'Neil, Jennifer

“…Myc, a transcription factor with oncogenic activity, is upregulated by amplification, translocation, and mutation of the cellular pathways that regulate its…”
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The phylum Nanoarchaeota: Present knowledge and future perspectives of a unique form of life by Huber, Harald, Hohn, Michael J, Stetter, Karl O, Rachel, Reinhard

“…The “Nanoarchaeota” are a novel archaeal phylum, forming a unique, deep branch in the 16S rRNA based phylogenetic tree of life. “ Nanoarchaeum equitans”, the…”
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Detection of 16S rDNA Sequences Representing the Novel Phylum “Nanoarchaeota”: Indication for a Wide Distribution in High Temperature Biotopes by Hohn, Michael J., Hedlund, Brian P., Huber, Harald

“…We screened samples from high temperature biotopes for 16S rRNA genes of the novel archaeal phylum “Nanoarchaeota”. Positive PCR amplifications were obtained…”
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Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index by Pissarnitski, Dmitri A, Kekec, Ahmet, Yan, Lin, Zhu, Yuping, Feng, Danqing D, Huo, Pei, Madsen-Duggan, Christina, Moyes, Christopher R, Nargund, Ravi P, Kelly, Terri, Zhang, Xiaoping, Carballo-Jane, Ester, Gorski, Judith, Zafian, Peter, Qatanani, Mo, Kaarsholm, Niels, Meng, Fanyu, Jia, Xiujuan, Lee, Keun-Joong, Wang, Weixun, Xu, Sherrie, Hohn, Michael J, Iammarino, Michael J, McCoy, Mark A, Okoh, Grace A, Liang, Yingkai, Hollingsworth, Scott A, Erion, Mark D, Kelley, David E, Garbaccio, Robert M, Zhang, Amy, Mu, James, Lin, Songnian

“…We have identified a series of novel insulin receptor partial agonists (IRPAs) with a potential to mitigate the risk of hypoglycemia associated with the use of…”
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Rapid antibody conformational screening by matrix‐assisted laser desorption/ionization hydrogen‐deuterium exchange mass spectrometry by Mukherjee, Debopreeti, Trigo‐Mouriño, Pablo, Jiang, Yuan, Nowak, Timothy, Shchurik, Vladimir, Adpressa, Donovon A., Louie, Michael T., Reynolds, Shane R., Hohn, Michael J., Al‐Sayah, Mohammad Ahmed, Pirrone, Gregory F., Makarov, Alexey A.

“…Recent advances in the field of cancer biology have accelerated the discovery and development of novel biopharmaceuticals. At the forefront of these drug…”
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From one amino acid to another: tRNA-dependent amino acid biosynthesis by Sheppard, Kelly, Yuan, Jing, Hohn, Michael J, Jester, Brian, Devine, Kevin M, Söll, Dieter

“…Aminoacyl-tRNAs (aa-tRNAs) are the essential substrates for translation. Most aa-tRNAs are formed by direct aminoacylation of tRNA catalyzed by aminoacyl-tRNA…”
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Toward understanding phosphoseryl-tRNACys formation: The crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase by Kamtekar, Satwik, Hohn, Michael J, Park, Hee-Sung, Schnitzbauer, Michael, Sauerwald, Anselm, Söll, Dieter, Steitz, Thomas A

“…A number of archaeal organisms generate Cys-tRNACys in a two-step pathway, first charging phosphoserine (Sep) onto tRNACys and subsequently converting it to…”
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Nanoarchaeum equitans creates functional tRNAs from separate genes for their 5′- and 3′-halves by Söll, Dieter, Randau, Lennart, Münch, Richard, Hohn, Michael J, Jahn, Dieter

“…Analysis of the genome sequence of the small hyperthermophilic archaeal parasite Nanoarchaeum equitans has not revealed genes encoding the glutamate,…”
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A tRNA-dependent cysteine biosynthesis enzyme recognizes the selenocysteine-specific tRNA in Escherichia coli by Yuan, Jing, Hohn, Michael J., Sherrer, R. Lynn, Palioura, Sotiria, Su, Dan, Söll, Dieter

“…The essential methanogen enzyme Sep-tRNA:Cys-tRNA synthase (SepCysS) converts O-phosphoseryl-tRNACys (Sep-tRNACys) into Cys-tRNACys in the presence of a sulfur…”
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Back Cover: Rewiring Translation for Elongation Factor Tu-Dependent Selenocysteine Incorporation (Angew. Chem. Int. Ed. 5/2013) by Aldag, Caroline, Bröcker, Markus J., Hohn, Michael J., Prat, Laure, Hammond, Gifty, Plummer, Abigail, Söll, Dieter

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