Search Results - "Hohn, Christoph"

Enantio‐ and Diastereoselective Synthesis of Chiral Allenes by Palladium‐Catalyzed Asymmetric [3+2] Cycloaddition Reactions by Trost, Barry M., Zell, Daniel, Hohn, Christoph, Mata, Guillaume, Maruniak, Autumn

“…A protocol for the asymmetric synthesis of highly substituted chiral allenes with control of point and axial chirality has been developed. A…”
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Ruthenium-catalysed multicomponent synthesis of the 1,3-dienyl-6-oxy polyketide motif by Trost, Barry M., Cregg, James J., Hohn, Christoph, Bai, Wen-Ju, Zhang, Guoting, Tracy, Jacob S.

“…Polyketide natural products are an important class of biologically active compounds. Although substantial progress has been made on the synthesis of repetitive…”
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Enantioselective Synthesis of des-Epoxy-Amphidinolide N by Trost, Barry M, Bai, Wen-Ju, Stivala, Craig E, Hohn, Christoph, Poock, Caroline, Heinrich, Marc, Xu, Shiyan, Rey, Jullien

“…The synthesis of des-epoxy-amphidinolide N was achieved in 22 longest linear and 33 total steps. Three generations of synthetic endeavors are reported herein…”
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Bus Riding as Amplification Mechanism for SARS-CoV-2 Transmission, Germany, 20211 by Scholl, Meike, Hohn, Christoph, Boucsein, Johannes, Moek, Felix, Plath, Jasper, Heiden, Maria an der, Huska, Matthew, Kroger, Stefan, Paraskevopoulou, Sofia, Siffczyk, Claudia, Buchholz, Udo, Lachmann, Raskit

“…To examine the risk associated with bus riding and identify transmission chains, we investigated a COVID-19 outbreak in Germany in 2021 that involved index…”
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Bus Riding as Amplification Mechanism for SARS-CoV-2 Transmission, Germany, 2021 by Schöll, Meike, Höhn, Christoph, Boucsein, Johannes, Moek, Felix, Plath, Jasper, Maria an der Heiden, Huska, Matthew, Kröger, Stefan, Paraskevopoulou, Sofia, Siffczyk, Claudia, Buchholz, Udo, Lachmann, Raskit

“…To examine the risk associated with bus riding and identify transmission chains, we investigated a COVID-19 outbreak in Germany in 2021 that involved index…”
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Palladium-Catalyzed Asymmetric Allylic Alkylation of 3‑Substituted 1H‑Indoles and Tryptophan Derivatives with Vinylcyclopropanes by Trost, Barry M, Bai, Wen-Ju, Hohn, Christoph, Bai, Yu, Cregg, James J

“…Vinylcyclopropanes (VCPs) are known to generate 1,3-dipoles with a palladium catalyst that initially serve as nucleophiles to undergo [3 + 2] cycloadditions…”
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Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Substituted 1 H -Indoles and Tryptophan Derivatives with Vinylcyclopropanes by Trost, Barry M., Bai, Wen-Ju, Hohn, Christoph, Bai, Yu, Cregg, James J.

“…Vinylcyclopropanes (VCPs) are known to generate 1,3-dipoles with a palladium catalyst that initially serve as nucleophiles to undergo [3 + 2] cycloadditions…”
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Chasing Protons: How Isothermal Titration Calorimetry, Mutagenesis, and p K a Calculations Trace the Locus of Charge in Ligand Binding to a tRNA-Binding Enzyme by Neeb, Manuel, Czodrowski, Paul, Heine, Andreas, Barandun, Luzi Jakob, Hohn, Christoph, Diederich, François, Klebe, Gerhard

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Chasing Protons: How Isothermal Titration Calorimetry, Mutagenesis, and pK a Calculations Trace the Locus of Charge in Ligand Binding to a tRNA-Binding Enzyme by Neeb, Manuel, Czodrowski, Paul, Heine, Andreas, Barandun, Luzi Jakob, Hohn, Christoph, Diederich, François, Klebe, Gerhard

“…Drug molecules should remain uncharged while traveling through the body and crossing membranes and should only adopt charged state upon protein binding,…”
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Occupying a flat subpocket in a tRNA-modifying enzyme with ordered or disordered side chains: Favorable or unfavorable for binding? by Neeb, Manuel, Hohn, Christoph, Ehrmann, Frederik Rainer, Härtsch, Adrian, Heine, Andreas, Diederich, François, Klebe, Gerhard

“…Small-molecule ligands binding with partial disorder or enhanced residual mobility are usually assumed as unfavorable with respect to their binding properties…”
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Swapping Interface Contacts in the Homodimeric tRNA‐Guanine Transglycosylase: An Option for Functional Regulation by Ehrmann, Frederik Rainer, Kalim, Jorna, Pfaffeneder, Toni, Bernet, Bruno, Hohn, Christoph, Schäfer, Elisabeth, Botzanowski, Thomas, Cianférani, Sarah, Heine, Andreas, Reuter, Klaus, Diederich, François, Klebe, Gerhard

“…The enzyme tRNA‐guanine transglycosylase, a target to fight Shigellosis, recognizes tRNA only as a homodimer and performs full nucleobase exchange at the…”
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Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT by Hassaan, Engi, Hohn, Christoph, Ehrmann, Frederik R, Goetzke, F. Wieland, Movsisyan, Levon, Hüfner-Wulsdorf, Tobias, Sebastiani, Maurice, Härtsch, Adrian, Reuter, Klaus, Diederich, François, Klebe, Gerhard

“…Fragment-based lead discovery was applied to tRNA-guanine transglycosylase, an enzyme modifying post-transcriptionally tRNAs in Shigella, the causative agent…”
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Beyond Affinity: Enthalpy–Entropy Factorization Unravels Complexity of a Flat Structure–Activity Relationship for Inhibition of a tRNA-Modifying Enzyme by Neeb, Manuel, Betz, Michael, Heine, Andreas, Barandun, Luzi Jakob, Hohn, Christoph, Diederich, François, Klebe, Gerhard

“…Lead optimization focuses on binding-affinity improvement. If a flat structure–activity relationship is detected, usually optimization strategies are abolished…”
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Impact of protein and ligand impurities on ITC-derived protein–ligand thermodynamics by Grüner, Stefan, Neeb, Manuel, Barandun, Luzi Jakob, Sielaff, Frank, Hohn, Christoph, Kojima, Shun, Steinmetzer, Torsten, Diederich, François, Klebe, Gerhard

“…The thermodynamic characterization of protein–ligand interactions by isothermal titration calorimetry (ITC) is a powerful tool in drug design, giving valuable…”
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An Immucillin-Based Transition-State-Analogous Inhibitor of tRNA-Guanine Transglycosylase (TGT) by Hohn, Christoph, Härtsch, Adrian, Ehrmann, Frederik Rainer, Pfaffeneder, Toni, Trapp, Nils, Dumele, Oliver, Klebe, Gerhard, Diederich, François

“…Shigellosis is one of the most severe diarrheal diseases worldwide without any efficient treatment so far. The enzyme tRNA–guanine transglycosylase (TGT) has…”
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Enantio‐ and Diastereoselective Synthesis of Chiral Allenes by Palladium‐Catalyzed Asymmetric [3+2] Cycloaddition Reactions by Trost, Barry M., Zell, Daniel, Hohn, Christoph, Mata, Guillaume, Maruniak, Autumn

“…A protocol for the asymmetric synthesis of highly substituted chiral allenes with control of point and axial chirality has been developed. A…”
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SiGe BiCMOS FMCW Photonic-Radar Transmitter for Automotive Applications by Hohn, Christoph, Caliskan, Can, Meuer, Christian, Rhee, Hanjo, Keil, Ulrich, Gisder, Thomas, Meinecke, Marc-Michael, Kurz, Heiko Gustav

“…In this work, a W-Band SiGe BiCMOS Transmitter (Tx) chip design is presented which realizes Electro-Photonic Circuit integration for Frequency-Modulated…”
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Photonic Radar System Considerations for an Analog Optical Channel by Hohn, Christoph, Caliskan, Can, Kupijai, Sebastian, Rhee, Hanjo, Keil, Ulrich, Gisder, Thomas, Meinecke, Marc-Michael, Kurz, Heiko Gustav

“…In this work, an analog optical channel is analyzed regarding its features to work in the signal chain of an automotive FMCW photonic radar system which…”
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Austausch der Proteinkontaktflächen in der homodimeren tRNA‐Guanin‐Transglycosylase: ein Weg der funktionellen Regulation by Ehrmann, Frederik Rainer, Kalim, Jorna, Pfaffeneder, Toni, Bernet, Bruno, Hohn, Christoph, Schäfer, Elisabeth, Botzanowski, Thomas, Cianférani, Sarah, Heine, Andreas, Reuter, Klaus, Diederich, François, Klebe, Gerhard

“…tRNA‐Guanin‐Transglycosylase, ein Target zur Therapie der Shigellen‐Ruhr, erkennt tRNA nur als Homodimer und führt einen kompletten Nucleobasen‐Austausch an…”
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Chasing protons: how isothermal titration calorimetry, mutagenesis, and pKa calculations trace the locus of charge in ligand binding to a tRNA-binding enzyme by Neeb, Manuel, Czodrowski, Paul, Heine, Andreas, Barandun, Luzi Jakob, Hohn, Christoph, Diederich, François, Klebe, Gerhard

“…Drug molecules should remain uncharged while traveling through the body and crossing membranes and should only adopt charged state upon protein binding,…”
Get full text