Search Results - "Hohman, C"

Neuropathy in diabetic mice overexpressing human aldose reductase and effects of aldose reductase inhibitor by Yagihashi, Soroku, Yamagishi, Shin-Ichiro, Wada, Ryu-ichi, Baba, Masayuki, Hohman, Thomas C., Yabe-Nishimura, Chihiro, Kokai, Yasuo

“…The present study was designed to examine the effect of aldose reductase (AR) overexpression on the development of diabetic neuropathy by using mice transgenic…”
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Protein kinase C effects on nerve function, perfusion, Na+, K+-ATPase activity and glutathione content in diabetic rats by CAMERON, N. E, COTTER, M. A, JACK, A. M, BASSO, HOHMAN, T. C

“…Increased protein kinase C activity has been linked to diabetic vascular complications in the retina and kidney, which were attenuated by protein kinase C…”
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Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability by Rodrigues, Gerard A, Mason, Matthew, Christie, Lori-Ann, Hansen, Candice, Hernandez, Lisa M, Burke, James, Luhrs, Keith A, Hohman, Thomas C

“…DARPin molecules are a novel class of small proteins that contain engineered ankyrin repeat domain(s) and bind to target proteins with high specificity and…”
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Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells by Zhang, Shao-LING, Filep, Janos G., Hohman, Thomas C., Tang, Shiow-SHIH, Ingelfinger, Julie R., Chan, John S.D.

“…Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells. Clinical studies have shown that the…”
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Reticular drusen associated with geographic atrophy in age-related macular degeneration by Schmitz-Valckenberg, Steffen, Alten, Florian, Steinberg, Julia S, Jaffe, Glenn J, Fleckenstein, Monika, Mukesh, Bickol N, Hohman, Thomas C, Holz, Frank G

“…To characterize reticular drusen (RDR) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) in a prospective,…”
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Streptozotocin-Induced Diabetes Causes Metabolic Changes and Alterations in Neurotrophin Content and Retrograde Transport in the Cervical Vagus Nerve by Lee, Paek-Gyu, Hohman, Thomas C., Cai, Fang, Regalia, Jen, Helke, Cinda J.

“…Abnormal availability of neurotrophins, such as nerve growth factor (NGF), has been implicated in diabetic somatosensory polyneuropathy. However, the…”
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Drug Intervention Can Correct Subnormal Retinal Oxygenation Response in Experimental Diabetic Retinopathy by Berkowitz, Bruce A, Roberts, Robin, Luan, Hongmei, Peysakhov, Jamie, Knoerzer, Deborah L, Connor, Jane R, Hohman, Thomas C

“…Early subnormal retinal oxygenation response to a hyperoxic provocation (DeltaPo2) is strongly associated with subsequent experimental diabetic retinopathy and…”
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Double-Masked, Randomized, Phase 2 Evaluation of Abicipar Pegol (an Anti-VEGF DARPin Therapeutic) in Neovascular Age-Related Macular Degeneration by Callanan, David, Kunimoto, Derek, Maturi, Raj K, Patel, Sunil S, Staurenghi, Giovanni, Wolf, Sebastian, Cheetham, Janet K, Hohman, Thomas C, Kim, Kimmie, López, Francisco J, Schneider, Susan

“…To evaluate safety and efficacy of the vascular endothelial growth factor binding protein abicipar pegol (abicipar) versus ranibizumab for neovascular…”
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Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats by CAMERON, N. E, COTTER, M. A, BASSO, M, HOHMAN, T. C

“…Aldose reductase inhibitors (ARIs) attenuate diabetic complications in several tissues, including lens, retina, kidney, blood vessels, striated muscle and…”
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Subnormal Retinal Oxygenation Response Precedes Diabetic-like Retinopathy by Berkowitz, Bruce A, Kowluru, Renu A, Frank, Robert N, Kern, Timothy S, Hohman, Thomas C, Prakash, Manvi

“…Determining which patients are at risk for the development of diabetic retinopathy is expected to greatly improve existing prevention and treatment options. In…”
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Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration by Schmitz-Valckenberg, Steffen, Fleckenstein, Monika, Göbel, Arno P, Hohman, Thomas C, Holz, Frank G

“…To analyze outer retinal changes within the atrophic lesion in patients with geographic atrophy (GA) secondary to age-related macular degeneration. Twenty-one…”
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Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats by CAMERON, N. E, COTTER, M. A, HOHMAN, T. C

“…Impaired omega-6 essential fatty acid metabolism and exaggerated polyol pathway flux contribute to the neurovascular abnormalities in streptozotocin-diabetic…”
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Novel Spirosuccinimide Aldose Reductase Inhibitors Derived from Isoquinoline-1,3-diones: 2-[(4-Bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4(11H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and Congeners. 1 by Malamas, Michael S, Hohman, Thomas C, Millen, Jane

“…The high concentrations of plasma glucose formed during diabetic hyperglycemia rapidly translate into high levels of glucose in tissues where glucose uptake is…”
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Hypertonic stress induces alpha B-crystallin expression by Dasgupta, S, Hohman, T C, Carper, D

“…Alpha B-crystallin, a major lens protein, was induced in primary cultures of dog lens epithelial cells and glomerular endothelial cells when they were grown…”
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Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes by Akamine, Eliana H, Hohman, Thomas C, Nigro, Dorothy, Carvalho, Maria Helena C, de Cássia Tostes, Rita, Fortes, Zuleica B

“…We demonstrated that aldose reductase inhibition corrects the impaired microvascular responses to inflammatory mediators in diabetic rats. To study the…”
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Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents by Wrobel, Jay, Dietrich, Arlene, Woolson, Shiela A, Millen, Jane, McCaleb, Michael, Harrison, Maria C, Hohman, Thomas C, Sredy, Janet, Sullivan, Donald

“…Compounds from two novel series of spirosuccinimides were prepared. Analogs of series 2 possessed a spiro-fused isoindolone moiety while those of series 3…”
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Generating an artificially thickened boundary layer to simulate the neutral atmospheric boundary layer by Hohman, T.C., Buren, T. Van, Martinelli, L., Smits, A.J.

“…We aim to generate an artificially thickened boundary layer in a wind tunnel with properties similar to the neutral atmospheric boundary layer. We implement a…”
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The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy. A meta-analysis of individual patient data by NICOLUCCI, A, CARINCI, F, GRAEPEL, J. G, HOHMAN, T. C, FERRIS, F, LACHIN, J. M

“…The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy. A meta-analysis of individual patient data. A Nicolucci , F Carinci , J G Graepel…”
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Molecular Modeling of the Aldose Reductase-Inhibitor Complex Based on the X-ray Crystal Structure and Studies with Single-Site-Directed Mutants by Singh, Suresh B, Malamas, Michael S, Hohman, Thomas C, Nilakantan, Ramaswamy, Carper, Deborah A, Kitchen, Douglas

“…Aldose reductase (AR) has been implicated in the etiology of the secondary complications of diabetes. This enzyme catalyzes the reduction of glucose to…”
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Influence of tolrestat on the defective leukocyte–endothelial interaction in experimental diabetes by Cruz, José Walber M.C, Oliveira, Maria A, Hohman, Thomas C, Fortes, Zuleica B

“…One of the most devastating secondary complications of diabetes is the blunted inflammatory response that becomes evident even in the very early stages of…”
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