Search Results - "Hohlfeld, J. M."

Allergen exposure chambers: harmonizing current concepts and projecting the needs for the future – an EAACI Position Paper by Pfaar, O., Calderon, M. A., Andrews, C. P., Angjeli, E., Bergmann, K. C., Bønløkke, J. H., Blay, F., Devillier, P., Ellis, A. K., Gerth van Wijk, R., Hohlfeld, J. M., Horak, F., Jacobs, R. L., Jacobsen, L., Jutel, M., Kaul, S., Larché, M., Larenas‐Linnemann, D., Mösges, R., Nolte, H., Patel, P., Peoples, L., Rabin, R. L., Rather, C., Salapatek, A. M., Sigsgaard, T., Thaarup, S., Yang, J., Zieglmayer, P., Zuberbier, T., Demoly, P.

“…Background Allergen exposure chambers (AECs) are clinical facilities allowing for controlled exposure of subjects to allergens in an enclosed environment. AECs…”
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Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber by Lueer, K., Biller, H., Casper, A., Windt, H., Mueller, M., Badorrek, P., Haefner, D., Framke, T., Koch, A., Ziehr, H., Krug, N., Koch, W., Hohlfeld, J. M.

“…Background Efficacy testing of immunotherapy in field studies is often hampered by variation of airborne allergens. Standardized allergen exposure in challenge…”
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Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions by Hohlfeld, J. M., Holland-Letz, T., Larbig, M., Lavae-Mokhtari, M., Wierenga, E., Kapsenberg, M., Van Ree, R., Krug, N., Bufe, A.

“…Summary Background Efficacy testing of drugs in seasonal allergic rhinitis (SAR) is often disturbed by seasonal variations of environmental allergens, and…”
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Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease by Hohlfeld, J.M., Sharma, A., van Noord, J.A., Cornelissen, P.J.G., Derom, E., Towse, L., Peterkin, V., Disse, B.

“…The aim of the study was to characterize pharmacokinetics of tiotropium solution 5 µg compared to powder 18 µg and assess dose‐dependency of tiotropium…”
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Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices by Switalla, S., Lauenstein, L., Prenzler, F., Knothe, S., Förster, C., Fieguth, H.-G., Pfennig, O., Schaumann, F., Martin, C., Guzman, C.A., Ebensen, T., Müller, M., Hohlfeld, J.M., Krug, N., Braun, A., Sewald, K.

“…Prediction of lung innate immune responses is critical for developing new drugs. Well-established immune modulators like lipopolysaccharides (LPS) can elicit a…”
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Allergen Challenge Increases Anandamide in Bronchoalveolar Fluid of Patients With Allergic Asthma by Zoerner, A A, Stichtenoth, D O, Engeli, S, Batkai, S, Winkler, C, Schaumann, F, Janke, J, Holz, O, Krug, N, Tsikas, D, Jordan, J, Hohlfeld, J M

“…Preclinical studies suggest that the endocannabinoid anandamide restrains allergic airway obstruction and inflammation. Therefore, we applied saline or…”
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Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model--a clinical trial by Holz, Olaf, Biller, H, Mueller, M, Kane, K, Rosano, M, Hanrahan, J, Hava, D L, Hohlfeld, J M

“…The ozone challenge model can be used to assess the efficacy of anti-inflammatory compounds in early phases of clinical drug development. PUR118, a calcium…”
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Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis by Krug, N., Loedding, H., Hohlfeld, J. M., Larbig, M., Buckendahl, A., Badorrek, P., Geldmacher, H., Behnke, W., Dunkhorst, W., Windt, H., Luettig, B., Koch, W.

“…Summary Background There is an increasing need for allergen inhalation systems to perform basic clinical research and test anti‐allergic drugs under…”
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Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice by Erpenbeck, V. J., Ziegert, M., Cavalet-Blanco, D., Martin, C., Baelder, R., Glaab, T., Braun, A., Steinhilber, W., Luettig, B., Uhlig, S., Hoymann, H. G., Krug, N., Hohlfeld, J. M.

“…Summary Background The surfactant protein SP‐D has been reported to reduce bronchial hyper‐responsiveness, blood eosinophilia, and T‐helper type 2 cytokines in…”
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Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma by Erpenbeck, V. J., Schmidt, R., Günther, A., Krug, N., Hohlfeld, J. M.

“…Background:  Allergic asthma is associated with airway inflammation and dysfunction of pulmonary surfactant. Because surfactant proteins (SP) account for…”
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Rating sputum cell quality in clinical trials for asthma and COPD treatment by Pedersen, Frauke, Zissler, Ulrich M, Watz, Henrik, Rabe, Klaus F, Hohlfeld, Jens M, Holz, Olaf

“…Background Induced sputum is a method to assess airway inflammation in clinical trials for asthma and COPD.1–3 Sputum is a heterogeneous, viscous material…”
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Effect of loteprednol etabonate nasal spray suspension on seasonal allergic rhinitis assessed by allergen challenge in an environmental exposure unit by Krug, N., Hohlfeld, J. M., Geldmacher, H., Larbig, M., Heermann, R., LaVallee, N., Nguyen, D. T., Petzold, U., Hermann, R.

“…Background:  Loteprednol etabonate (LE) is a novel soft steroid that was designed to improve the benefit/risk ratio of topical corticosteroid therapy. This…”
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Determination of cardiac output by the Fick method, thermodilution, and acetylene rebreathing in pulmonary hypertension by HOEPER, M. M, MAIER, R, TONGERS, J, NIEDERMEYER, J, HOHLFELD, J. M, HAMM, M, FABEL, H

“…Assessment of cardiac output is an important part of the management of patients with pulmonary hypertension. The accuracy of the thermodilution technique in…”
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Lung fibroblasts from patients with emphysema show markers of senescence in vitro by Müller, K-C, Welker, L, Paasch, K, Feindt, B, Erpenbeck, V J, Hohlfeld, J M, Krug, N, Nakashima, M, Branscheid, D, Magnussen, H, Jörres, R A, Holz, O

“…The loss of alveolar walls is a hallmark of emphysema. As fibroblasts play an important role in the maintenance of alveolar structure, a change in fibroblast…”
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Keratinocyte growth factor prevents intra-alveolar oedema in experimental lung isografts by Sadovski, J, Kuchenbuch, T, Ruppert, C, Fehrenbach, A, Hirschburger, M, Padberg, W, Gunther, A, Hohlfeld, J. M, Fehrenbach, H, Grau, V

“…Primary graft dysfunction, characterised by intra-alveolar oedema, is a major obstacle in pulmonary transplantation. The present study evaluates the potential…”
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Left heart function in COPD: Impact of lung deflation by Struß, N., Bauersachs, J., Welte, T., Hohlfeld, J. M.

“…Chronic obstructive pulmonary disease (COPD) primarily affects the lungs; however, cardiovascular conditions are among the most common extrapulmonary…”
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Hyperuricaemia in patients with right or left heart failure by Hoeper, MM, Hohlfeld, JM, Fabel, H

“…Based on the clinical observation that patients with right or left heart failure often present with hyperuricaemia, the relation between serum urate values and…”
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Effect of anti‐nerve growth factor on early and late airway responses in allergic rats by Glaab, T., Hoymann, H. G., Hecht, M., Korolewitz, R., Tschernig, T., Hohlfeld, J. M., Krug, N., Braun, A.

“…Background: The increased production of nerve growth factor (NGF) has been associated with allergen‐induced airway hyperresponsiveness and enhanced airway…”
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A dual center study to compare breath volatile organic compounds from smokers and non-smokers with and without COPD by Gaida, A, Holz, O, Nell, C, Schuchardt, S, Lavae-Mokhtari, B, Kruse, L, Boas, U, Langejuergen, J, Allers, M, Zimmermann, S, Vogelmeier, C, Koczulla, A R, Hohlfeld, J M

“…There is increasing evidence that breath volatile organic compounds (VOC) have the potential to support the diagnosis and management of inflammatory diseases…”
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Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS by Allers, M, Langejuergen, J, Gaida, A, Holz, O, Schuchardt, S, Hohlfeld, J M, Zimmermann, S

“…Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore,…”
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