Search Results - "Hohenstein, Peter"

The yin and yang of kidney development and Wilms' tumors by Hohenstein, Peter, Pritchard-Jones, Kathy, Charlton, Jocelyn

“…Wilms' tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture…”
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Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney by Munro, David A. D., Hohenstein, Peter, Davies, Jamie A.

“…The renal vasculature is required for blood filtration, blood pressure regulation, and pH maintenance, as well as other specialised kidney functions. Yet,…”
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Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor by Li, Hao, Hohenstein, Peter, Kuure, Satu

“…The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that could replenish functional homeostasis similarly to, e.g., skin or the…”
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Osteocalcin Regulates Arterial Calcification Via Altered Wnt Signaling and Glucose Metabolism by Rashdan, Nabil A, Sim, Alisia M, Cui, Lin, Phadwal, Kanchan, Roberts, Fiona L, Carter, Roderick, Ozdemir, Derya D, Hohenstein, Peter, Hung, John, Kaczynski, Jakub, Newby, David E, Baker, Andrew H, Karsenty, Gerard, Morton, Nicholas M, MacRae, Vicky E

“…ABSTRACT Arterial calcification is an important hallmark of cardiovascular disease and shares many similarities with skeletal mineralization. The bone‐specific…”
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The stem and roots of Wilms' tumours by Hohenstein, Peter

“…See related article in EMBO Molecular Medicine http://dx.doi.org/10.1002/emmm.201201516…”
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Characterization of Alternative Splicing in High-Risk Wilms' Tumors by Trink, Yaron, Urbach, Achia, Dekel, Benjamin, Hohenstein, Peter, Goldberger, Jacob, Kalisky, Tomer

“…The significant heterogeneity of Wilms' tumors between different patients is thought to arise from genetic and epigenetic distortions that occur during various…”
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WT1 in disease: shifting the epithelial-mesenchymal balance by Miller-Hodges, Eve, Hohenstein, Peter

“…WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue‐context dependent manner. As such, WT1 is…”
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Characterization of Continuous Transcriptional Heterogeneity in High-Risk Blastemal-Type Wilms' Tumors Using Unsupervised Machine Learning by Trink, Yaron, Urbach, Achia, Dekel, Benjamin, Hohenstein, Peter, Goldberger, Jacob, Kalisky, Tomer

“…Wilms' tumors are pediatric malignancies that are thought to arise from faulty kidney development. They contain a wide range of poorly differentiated cell…”
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2- and 3-dimensional synthetic large-scale de novo patterning by mammalian cells through phase separation by Cachat, Elise, Liu, Weijia, Martin, Kim C., Yuan, Xiaofei, Yin, Huabing, Hohenstein, Peter, Davies, Jamie A.

“…Synthetic biology provides an opportunity for the construction and exploration of alternative solutions to biological problems - solutions different from those…”
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Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction by Bharathavikru, Ruthrothaselvi, Dudnakova, Tatiana, Aitken, Stuart, Slight, Joan, Artibani, Mara, Hohenstein, Peter, Tollervey, David, Hastie, Nick

“…Wilms' tumor 1 (WT1) is essential for the development and homeostasis of multiple mesodermal tissues. Despite evidence for post-transcriptional roles, no…”
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Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin by Hastie, Nicholas D, Martínez-Estrada, Ofelia M, Lettice, Laura A, Essafi, Abdelkader, Guadix, Juan Antonio, Slight, Joan, Velecela, Víctor, Hall, Emma, Reichmann, Judith, Devenney, Paul S, Hohenstein, Peter, Hosen, Naoki, Hill, Robert E, Muñoz-Chapuli, Ramón

“…Nicholas Hastie and colleagues show that Wt1 is required for the epithelial-to-mesenchymal (EMT) transition in the developing epicardium and the formation of…”
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Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development by Munro, David AD, Wineberg, Yishay, Tarnick, Julia, Vink, Chris S, Li, Zhuan, Pridans, Clare, Dzierzak, Elaine, Kalisky, Tomer, Hohenstein, Peter, Davies, Jamie A

“…The origins and functions of kidney macrophages in the adult have been explored, but their roles during development remain largely unknown. Here we…”
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Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation by Staines, Katherine A., Javaheri, Behzad, Hohenstein, Peter, Fleming, Robert, Ikpegbu, Ekele, Unger, Erin, Hopkinson, Mark, Buttle, David J., Pitsillides, Andrew A., Farquharson, Colin

“…The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and…”
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Activation of podocyte Notch mediates early Wt1 glomerulopathy by Asfahani, Rowan I, Tahoun, Mona M, Miller-Hodges, Eve V, Bellerby, Jack, Virasami, Alex K, Sampson, Robert D, Moulding, Dale, Sebire, Neil J, Hohenstein, Peter, Scambler, Peter J, Waters, Aoife M

“…The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations…”
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A Wt1-Controlled Chromatin Switching Mechanism Underpins Tissue-Specific Wnt4 Activation and Repression by Essafi, Abdelkader, Webb, Anna, Berry, Rachel L., Slight, Joan, Burn, Sally F., Spraggon, Lee, Velecela, Victor, Martinez-Estrada, Ofelia M., Wiltshire, John H., Roberts, Stefan G.E., Brownstein, David, Davies, Jamie A., Hastie, Nicholas D., Hohenstein, Peter

“…Wt1 regulates the epithelial-mesenchymal transition (EMT) in the epicardium and the reverse process (MET) in kidney mesenchyme. The mechanisms underlying these…”
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Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1 by Chau, You-Ying, Brownstein, David, Mjoseng, Heidi, Lee, Wen-Chin, Buza-Vidas, Natalija, Nerlov, Claus, Jacobsen, Sten Eirik, Perry, Paul, Berry, Rachel, Thornburn, Anna, Sexton, David, Morton, Nik, Hohenstein, Peter, Freyer, Elisabeth, Samuel, Kay, van't Hof, Rob, Hastie, Nicholas

“…There is much interest in the mechanisms that regulate adult tissue homeostasis and their relationship to processes governing foetal development. Mice deleted…”
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Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease by Harari‐Steinberg, Orit, Metsuyanim, Sally, Omer, Dorit, Gnatek, Yehudit, Gershon, Rotem, Pri‐Chen, Sara, Ozdemir, Derya D., Lerenthal, Yaniv, Noiman, Tzahi, Ben‐Hur, Herzel, Vaknin, Zvi, Schneider, David F., Aronow, Bruce J., Goldstein, Ronald S., Hohenstein, Peter, Dekel, Benjamin

“…Identification of tissue‐specific renal stem/progenitor cells with nephrogenic potential is a critical step in developing cell‐based therapies for renal…”
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SCON—a Short Conditional intrON for conditional knockout with one-step zygote injection by Wu, Szu-Hsien Sam, Lee, Heetak, Szép-Bakonyi, Réka, Colozza, Gabriele, Boese, Ayse, Gert, Krista R., Hallay, Natalia, Lee, Ji-Hyun, Kim, Jihoon, Zhu, Yi, Linssen, Margot M., Pilat-Carotta, Sandra, Hohenstein, Peter, Theussl, Hans-Christian, Pauli, Andrea, Koo, Bon-Kyoung

“…The generation of conditional alleles using CRISPR technology is still challenging. Here, we introduce a Short Conditional intrON (SCON, 189 bp) that enables…”
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Author Correction: SCON—a Short Conditional intrON for conditional knockout with one-step zygote injection by Wu, Szu-Hsien Sam, Lee, Heetak, Szép-Bakonyi, Réka, Colozza, Gabriele, Boese, Ayse, Gert, Krista R., Hallay, Natalia, Lee, Ji-Hyun, Kim, Jihoon, Zhu, Yi, Linssen, Margot M., Pilat-Carotta, Sandra, Hohenstein, Peter, Theussl, Hans-Christian, Pauli, Andrea, Koo, Bon-Kyoung

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The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling by Lindström, Nils Olof, Carragher, Neil Oliver, Hohenstein, Peter

“…Nephron progenitor cells differentiate to form nephrons during embryonic kidney development. In contrast, self-renewal maintains progenitor numbers and…”
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