Gene expression analysis of MAOA and the clock gene ARNTL in individuals with bipolar disorder compared to healthy controls

Circadian rhythms are associated with bipolar disorder (BD). This cross-sectional study aimed at investigating ARNTL and MAOA gene expression differences (1) between individuals with BD and controls, (2) between affective episodes, and (3) the relationship between ARNTL and MAOA expression. ARNTL an...

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Bibliographic Details
Published in:	The world journal of biological psychiatry Vol. 23; no. 4; pp. 287 - 294
Main Authors:	Bengesser, S. A., Hohenberger, H., Tropper, B., Dalkner, N., Birner, A., Fellendorf, F. T., Platzer, M., Rieger, A., Maget, A., Hamm, C., Queissner, R., Pilz, R., Bauer, K., Lenger, M., Mörkl, S., Wagner-Skacel, J., Kapfhammer, H. P., Meier-Allard, N., Stracke, A., Holasek, S. J., Murphy, L., Reininghaus, E. Z.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 07-04-2022
Subjects:	ARNTL ARNTL Transcription Factors - genetics Bipolar disorder Bipolar Disorder - genetics Circadian Rhythm - genetics clock genes Cross-Sectional Studies Gene Expression Humans MAOA Monoamine Oxidase - genetics Bipolar disorder clock genes MAOA ARNTL
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Summary:	Circadian rhythms are associated with bipolar disorder (BD). This cross-sectional study aimed at investigating ARNTL and MAOA gene expression differences (1) between individuals with BD and controls, (2) between affective episodes, and (3) the relationship between ARNTL and MAOA expression. ARNTL and MAOA gene expression in peripheral mononuclear blood cells were analysed from fasting blood samples (BD n = 81, controls n = 54) with quantitative real-time PCR operating on TaqMan® assays (normalised to 18S RNA expression). ANCOVAs corrected for age, sex, body mass index, and medication was used to evaluate expression differences and correlation analyses for the relation between ARNTL and MAOA expression. ARNTL gene expression differed between affective episodes (F(2,78) = 3.198, p = 0.047, Partial Eta 2 = 0.083), but not between BD and controls (n.s.). ARNTL and MAOA expression correlated positively in BD (r = 0.704, p < 0.001) and in controls (r = 0.932, p < 0.001). MAOA expression differed neither between BD and controls nor between affective episodes (n.s.). Clock gene expression changes were observed in different affective states of BD. More precisely, ARNTL gene expression was significantly higher in euthymia than in depression. ARNTL and MAOA gene expression correlated significantly in BD and in controls, which emphasises the strong concatenation between circadian rhythms and neurotransmitter breakdown.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1562-2975 1814-1412
DOI:	10.1080/15622975.2021.1973816