Search Results - "Hoh, Josephine"

Origin of dendritic cells in peripheral lymphoid organs of mice by Liu, Kang, Nussenzweig, Michel, Waskow, Claudia, Yao, Kaihui, Hoh, Josephine, Liu, Xiangtao

“…Parabiosis experiments demonstrating that dendritic cells (DCs) do not equilibrate between mice even after prolonged joining by parabiosis have suggested that…”
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GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21 by Wiemels, Joseph L., Walsh, Kyle M., de Smith, Adam J., Metayer, Catherine, Gonseth, Semira, Hansen, Helen M., Francis, Stephen S., Ojha, Juhi, Smirnov, Ivan, Barcellos, Lisa, Xiao, Xiaorong, Morimoto, Libby, McKean-Cowdin, Roberta, Wang, Rong, Yu, Herbert, Hoh, Josephine, DeWan, Andrew T., Ma, Xiaomei

“…Childhood acute lymphoblastic leukemia (ALL) (age 0–14 years) is 20% more common in Latino Americans than non-Latino whites. We conduct a genome-wide…”
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Genetic signatures of exceptional longevity in humans by Sebastiani, Paola, Solovieff, Nadia, Dewan, Andrew T, Walsh, Kyle M, Puca, Annibale, Hartley, Stephen W, Melista, Efthymia, Andersen, Stacy, Dworkis, Daniel A, Wilk, Jemma B, Myers, Richard H, Steinberg, Martin H, Montano, Monty, Baldwin, Clinton T, Hoh, Josephine, Perls, Thomas T

“…Like most complex phenotypes, exceptional longevity is thought to reflect a combined influence of environmental (e.g., lifestyle choices, where we live) and…”
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Mathematical multi-locus approaches to localizing complex human trait genes by Ott, Jurg, Hoh, Josephine

“…Statistical analysis methods for gene mapping originated in counting recombinant and non-recombinant offspring, but have now progressed to sophisticated…”
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Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site by Chen, Xiaocui, Li, Liqun, Liu, Fuhong, Hoh, Josephine, Kapron, Carolyn M, Liu, Ju

“…Cadmium (Cd) is an environmental toxin that induces nephrotoxicity. Complement factor H (CFH), an inhibitor of complement activation, is involved in the…”
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Systematically identifying genetic signatures including novel SNP-clusters, nonsense variants, frame-shift INDELs, and long STR expansions that potentially link to unknown phenotypes existing in dog breeds by Li, Zicheng, Wang, Zuoheng, Chen, Zhiyuan, Voegeli, Heidi, Lichtman, Judith H, Smith, Peter, Liu, Ju, DeWan, Andrew T, Hoh, Josephine

“…In light of previous studies that profiled breed-specific traits or used genome-wide association studies to refine loci associated with characteristic…”
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Complement Factor H Polymorphism in Age-Related Macular Degeneration by Klein, Robert J, Zeiss, Caroline, Chew, Emily Y, Tsai, Jen-Yue, Sackler, Richard S, Haynes, Chad, Henning, Alice K, SanGiovanni, John Paul, Mane, Shrikant M, Mayne, Susan T, Bracken, Michael B, Ferris, Frederick L, Ott, Jurg, Barnstable, Colin, Hoh, Josephine

“…Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for…”
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Loss of HtrA1-induced attenuation of TGF-β signaling in fibroblasts might not be the main mechanism of CARASIL pathogenesis by Liu, Ju, Dong, Fengyun, Hoh, Josephine

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Complement factor H in molecular regulation of angiogenesis by Li, Jiang, Wang, Kaili, Starodubtseva, Maria N., Nadyrov, Eldar, Kapron, Carolyn M., Hoh, Josephine, Liu, Ju

“…Angiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes…”
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Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients by Zhao, Linlu, Triche, Elizabeth W, Walsh, Kyle M, Bracken, Michael B, Saftlas, Audrey F, Hoh, Josephine, Dewan, Andrew T

“…Specific genetic contributions for preeclampsia (PE) are currently unknown. This genome-wide association study (GWAS) aims to identify maternal single…”
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Trimming, weighting, and grouping SNPs in human case-control association studies by Hoh, J, Wille, A, Ott, J

“…The search for genes underlying complex traits has been difficult and often disappointing. The main reason for these difficulties is that several genes, each…”
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Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease by Jo, Hakryul, Patterson, Victoria, Stoessel, Sean, Kuan, Chia-Yi, Hoh, Josephine

“…High temperature requirement protein A1 (HtrA1), a secreted serine protease of the HtrA family, is associated with a multitude of human diseases. However, the…”
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Stage and gene specific signatures defined by histones H3K4me2 and H3K27me3 accompany mammalian retina maturation in vivo by Popova, Evgenya Y, Xu, Xuming, DeWan, Andrew T, Salzberg, Anna C, Berg, Arthur, Hoh, Josephine, Zhang, Samuel S, Barnstable, Colin J

“…The epigenetic contribution to neurogenesis is largely unknown. There is, however, growing evidence that posttranslational modification of histones is a…”
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Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1 by Patterson, Victoria L, Zullo, Alfred J, Koenig, Claire, Stoessel, Sean, Jo, Hakryul, Liu, Xinran, Han, Jinah, Choi, Murim, DeWan, Andrew T, Thomas, Jean-Leon, Kuan, Chia-Yi, Hoh, Josephine

“…HTRA2, a serine protease in the intermembrane space, has important functions in mitochondrial stress signaling while its abnormal activity may contribute to…”
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Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration by SanGiovanni, John Paul, Arking, Dan E, Iyengar, Sudha K, Elashoff, Michael, Clemons, Traci E, Reed, George F, Henning, Alice K, Sivakumaran, Theru A, Xu, Xuming, DeWan, Andrew, Agrón, Elvira, Rochtchina, Elena, Sue, Carolyn M, Wang, Jie Jin, Mitchell, Paul, Hoh, Josephine, Francis, Peter J, Klein, Michael L, Chew, Emily Y, Chakravarti, Aravinda

“…Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people of…”
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Common Variants on Chromosome 2 and Risk of Primary Open-Angle Glaucoma in the Afro-Caribbean Population of Barbados by Jiao, Xiaodong, Yang, Zhenglin, Yang, Xian, Chen, Yuhong, Tong, Zongzhong, Zhao, Chao, Zeng, Jiexi, Chen, Haoyu, Gibbs, Daniel, Sun, Xufang, Li, Bei, Wakins, W. Scott, Meyer, Cynthia, Wang, Xiaolei, Kasuga, Daniel, Bedell, Matthew, Pearson, Erik, Weinreb, Robert N., Leske, M. Cristina, Hennis, Anselm, DeWan, Andrew, Nemesure, Barbara, Jorde, Lynn B., Hoh, Josephine, Hejtmandk, J. Fielding, Zhang, Kang, Seidman, Christine E.

“…Primary open-angle glaucoma (POAG) is the second leading cause of blindness worldwide. Although a number of genetic loci have shown association or genetic…”
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Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia by Spracklen, Cassandra N., Smith, Caitlin J., Saftlas, Audrey F., Triche, Elizabeth W., Bjonnes, Andrew, Keating, Brendan J., Saxena, Richa, Breheny, Patrick J., Dewan, Andrew T., Robinson, Jennifer G., Hoh, Josephine, Ryckman, Kelli K.

“…Objective: To examine the association between genetic predisposition to elevated C-reactive protein (CRP)and risk for preeclampsia using validated genetic loci…”
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The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration by Zhang, Hong, Morrison, Margaux A, Dewan, Andy, Adams, Scott, Andreoli, Michael, Huynh, Nancy, Regan, Maureen, Brown, Alison, Miller, Joan W, Kim, Ivana K, Hoh, Josephine, Deangelis, Margaret M

“…To examine if the significantly associated SNPs derived from the genome wide allelic association study on the AREDS cohort at the NEI (dbGAP) specifically…”
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A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum by Walsh, Kyle M, Choi, Murim, Oberg, Kjell, Kulke, Matthew H, Yao, James C, Wu, Chengqing, Jurkiewicz, Magdalena, Hsu, Ling-I, Hooshmand, Susanne M, Hassan, Manal, Janson, Eva T, Cunningham, Janet L, Vosburgh, Evan, Sackler, Richard S, Lifton, Richard P, DeWan, Andrew T, Hoh, Josephine

“…Genetic studies of midgut carcinoid cancer have exclusively focused on genomic changes of the tumor cells. We investigated the role of constitutional genetic…”
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Reply to Liu et al.: Differential effects of chromosome 2p16.3 variants on glaucoma in African derived populations by Zhang, Kang, Jiao, Xiaodong, Chen, Yuhong, Yang, Zhenglin, Hennis, Anselm, Nemesure, Barbara, Hoh, Josephine, Hejtmancik, J. Fielding

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