Search Results - "Hogue, B A"

Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction by Stuart, Jeff A., Karahalil, Bensu, Hogue, Barbara A., Souza‐Pinto, Nadja C., Bohr, Vilhelm A.

“…Aging is strongly correlated with the accumulation of oxidative damage in DNA, particularly in mitochondria. Oxidative damage to both mitochondrial and nuclear…”
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Age-associated change in mitochondrial DNA damage by Hudson, E K, Hogue, B A, Souza-Pinto, N C, Croteau, D L, Anson, R M, Bohr, V A, Hansford, R G

“…There is an age-associated decline in the mitochondrial function of the Wistar rat heart. Previous reports from this lab have shown a decrease in mitochondrial…”
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Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation by Moreno-Sánchez, R, Hogue, B A, Hansford, R G

“…1. We have examined systematically the relationship between the percentage reduction of cardiac mitochondrial NAD and the flux through oxidative…”
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Repair of 8-oxodeoxyguanosine lesions in mitochondrial DNA depends on the oxoguanine DNA glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial DNA of OGG1-defective mice by DE SOUZA-PINTO, Nadja C, EIDE, Lars, HOGUE, Barbara A, THYBO, Tanja, STEVNSNER, Tinna, SEEBERG, Erling, KLUNGLAND, Arne, BOHR, Vilhelm A

“…Mitochondria are not only the major site for generation of reactive oxygen species, but also one of the main targets of oxidative damage. One of the major…”
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Altered pyruvate dehydrogenase control and mitochondrial free Ca2+ in hearts of cardiomyopathic hamsters by Di Lisa, F, Fan, C Z, Gambassi, G, Hogue, B A, Kudryashova, I, Hansford, R G

“…The fraction of total pyruvate dehydrogenase in the active, dephosphorylated form is much lower in the glucose-perfused isolated hearts of two myopathic…”
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Cytosolic pH measurements in single cardiac myocytes using carboxy-seminaphthorhodafluor-1 by Blank, P S, Silverman, H S, Chung, O Y, Hogue, B A, Stern, M D, Hansford, R G, Lakatta, E G, Capogrossi, M C

“…This study examines the use of carboxy-seminaphthorhodafluor-1 (C-SNARF-1) as an indicator of cytosolic pH in isolated rat cardiac myocytes. The emission…”
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Effects of acidosis on resting cytosolic and mitochondrial Ca2+ in mammalian myocardium by GAMBASSI, G, HANSFORD, R. G, SOLLOTT, S. J, HOGUE, B. A, LAKATTA, E. G, CAPOGROSSI, M. C

“…Acidosis increases resting cytosolic [Ca2+], (Cai) of myocardial preparations; however, neither the Ca2+ sources for the increase in Cai nor the effect of…”
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Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age by Hansford, R G, Hogue, B A, Mildaziene, V

“…We have examined the substrate specificity and inhibitor sensitivity of H2O2 formation by rat heart mitochondria. Active H2O2 production requires both a high…”
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Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086 by Moreno-Sánchez, R, Hogue, B A, Bravo, C, Newman, A H, Basile, A S, Chiang, P K

“…The effects, of the benzodiazepines RO5-4864, AHN 086, PK 11195 and clonazepam on respiration of mitochondria from heart, kidney, and liver were studied…”
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Mitochondrial Toxin 3-Nitropropionic Acid Induces Cardiac and Neurotoxicity Differentially in Mice by Gabrielson, Kathleen L., Hogue, Barbara A., Bohr, Vilhelm A., Cardounel, A.J., Nakajima, Waco, Kofler, Julia, Zweier, Jay L., Rodriguez, E. Rene, Martin, Lee J., de Souza-Pinto, Nadja C., Bressler, Joseph

“…We investigated the effects of 3-nitropropionic acid (3NPA), a previously characterized neurotoxin, in four strains of mice to better understand the molecular…”
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DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts by de Souza-Pinto, Nadja C, Hogue, Barbara A, Bohr, Vilhelm A

“…8-oxo-deoxyguanosine (8-oxodG) is one of the major DNA lesions formed upon oxidative attack of DNA. It is a mutagenic adduct that has been associated with…”
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Basal Cell Carcinoma, Squamous Cell Carcinoma, and Cutaneous Melanoma in Skin of Color Patients by Hogue, Latrice, BA, Harvey, Valerie M., MD, MPH

“…Skin cancers are relatively rare in patients with skin of color; however, they are an important public health concern because of disparities in patient…”
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Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes by Hu, Jingping, de Souza-Pinto, Nadja C, Haraguchi, Kazuhiro, Hogue, Barbara A, Jaruga, Pawel, Greenberg, Marc M, Dizdaroglu, Miral, Bohr, Vilhelm A

“…The oxidatively induced DNA lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA) are formed abundantly in…”
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Base excision repair capacity in mitochondria and nuclei: tissue‐specific variations by Karahalil, Bensu, Hogue, Barbara A., Souza‐Pinto, Nadja C., Bohr, Vilhelm A.

“…ABSTRACT Base excision repair is the main pathway for repair of oxidative base lesions in DNA. Mammalian cells must maintain genomic stability in their nuclear…”
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Oxidized guanine lesions and hOgg1 activity in lung cancer by MAMBO, Elizabeth, CHATTERJEE, Aditi, DE SOUZA-PINTO, Nadja C, MAYARD, Sabine, HOGUE, Barbara A, HOQUE, Mohammad O, DIZDAROGLU, Mirai, BOHR, Vilhelm A, SIDRANSKY, David

“…In humans, the oxidatively induced DNA lesion 8-hydroxyguanine (8-oxoG) is removed from DNA by hOgg1, a DNA glycosylase/AP lyase that specifically incises…”
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Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B by STEVNSNER, Tinna, NYAGA, Simon, DE SOUZA-PINTO, Nadja C, VAN DER HORST, Gijsbertus T. J, GORGELS, Theo G. M. F, HOGUE, Barbara A, THORSLUND, Tina, BOHR, Vilhelm A

“…Reactive oxygen species, which are prevalent in mitochondria, cause oxidative DNA damage including the mutagenic DNA lesion 7,8-dihydroxyguanine (8-oxoG)…”
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DNA Damage Levels and Biochemical Repair Capacities Associated with XRCC1 Deficiency by Wong, Heng-Kuan, Kim, Daemyung, Hogue, Barbara A, McNeill, Daniel R, Wilson, David M

“…Base excision repair (BER) is the major corrective pathway for most spontaneous, oxidative, and alkylation DNA base and sugar damage. X-ray cross-complementing…”
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Abnormalities in stonefly eggs (Insecta: Plecoptera) by Stark, B.P, Cox, P.G, Lentz, D.L, Hogue, A.B

“…Abnormal, double-collar eggs of Neoperla robisoni Poulton and Stewart and Sweltsa exquisita (Frison) are described from scanning electron photomicrographs. The…”
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DNA repair and aging in mouse liver: 8-oxodeoxyglycosylase activity increase in mitochondrial but not in nuclear extracts by de Souza-Pinto, NC, Hogue, BA, Bohr, V A

“…8-oxo-deoxyguanosine (8-oxodG) is one of the major DNA lesions formed upon oxidative attack of DNA. It is a mutagenic adduct that has been associated with…”
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Mitochondrial repair of 8-oxguanine is deficient in Cockayne syndrome group B by Stevnsner, T, Nyaga, S, de Souza-Pinto, NC, van der Horst, GTJ, Gorgels, TGMF, Hogue, BA, Thorslund, T, Bohr, V A

“…Reactive oxygen species, which are prevalent in mitochondria, cause oxidative DNA damage including the mutagenic DNA lesion 7,8-dihydroxyguanine (8-oxoG)…”
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