Search Results - "Hoglund, Andreas"

Coverage Evaluation for 5G Reduced Capability New Radio (NR-RedCap) by Moloudi, Saeedeh, Mozaffari, Mohammad, Veedu, Sandeep Narayanan Kadan, Kittichokechai, Kittipong, Wang, Y.-P. Eric, Bergman, Johan, Hoglund, Andreas

“…The fifth-generation (5G) wireless technology is primarily designed to address a wide range of use cases categorized into the enhanced mobile broadband (eMBB),…”
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Analyzing Novel Grant-Based and Grant-Free Access Schemes for Small Data Transmission by Zhou, Hui, Deng, Yansha, Feltrin, Luca, Hoglund, Andreas

“…Fifth Generation (5G) New Radio (NR) does not support data transmission during random access (RA) procedures, which results in unnecessary control signalling…”
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Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies by Herold, Nikolas, Rudd, Sean G, Ljungblad, Linda, Sanjiv, Kumar, Myrberg, Ida Hed, Paulin, Cynthia B J, Heshmati, Yaser, Hagenkort, Anna, Kutzner, Juliane, Page, Brent D G, Calderón-Montaño, José M, Loseva, Olga, Jemth, Ann-Sofie, Bulli, Lorenzo, Axelsson, Hanna, Tesi, Bianca, Valerie, Nicholas C K, Höglund, Andreas, Bladh, Julia, Wiita, Elisée, Sundin, Mikael, Uhlin, Michael, Rassidakis, Georgios, Heyman, Mats, Tamm, Katja Pokrovskaja, Warpman-Berglund, Ulrika, Walfridsson, Julian, Lehmann, Sören, Grandér, Dan, Lundbäck, Thomas, Kogner, Per, Henter, Jan-Inge, Helleday, Thomas, Schaller, Torsten

“…The therapeutic response of acute myelogenous leukemia to the nucleoside analog ara-C is controlled by SAMHD1, an enzyme that hydrolyzes the activemetabolite…”
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Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells by HÖGLUND, Andreas, NILSSON, Lisa M, VEPPIL MURALIDHARAN, Somsundar, HASVOLD, Lisa A, MERTA, Philip, RUDELIUS, Martina, NIKOLOVA, Viktoriya, KELLER, Ulrich, NILSSON, Jonas A

“…The transcription factor c-Myc (or "Myc") is a master regulator of pathways driving cell growth and proliferation. MYC is deregulated in many human cancers,…”
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Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 by Llona-Minguez, Sabin, Höglund, Andreas, Jacques, Sylvain A, Johansson, Lars, Calderón-Montaño, José Manuel, Claesson, Magnus, Loseva, Olga, Valerie, Nicholas C. K, Lundbäck, Thomas, Piedrafita, Javier, Maga, Giovanni, Crespan, Emmanuele, Meijer, Laurent, Burgos Morón, Estefanía, Baranczewski, Pawel, Hagbjörk, Ann-Louise, Svensson, Richard, Wiita, Elisee, Almlöf, Ingrid, Visnes, Torkild, Jeppsson, Fredrik, Sigmundsson, Kristmundur, Jensen, Annika Jenmalm, Artursson, Per, Jemth, Ann-Sofie, Stenmark, Pål, Warpman Berglund, Ulrika, Scobie, Martin, Helleday, Thomas

“…The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide…”
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MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia by Sanjiv, Kumar, Calderón-Montaño, José Manuel, Pham, Therese M, Erkers, Tom, Tsuber, Viktoriia, Almlöf, Ingrid, Höglund, Andreas, Heshmati, Yaser, Seashore-Ludlow, Brinton, Nagesh Danda, Akhilesh, Gad, Helge, Wiita, Elisee, Göktürk, Camilla, Rasti, Azita, Friedrich, Stefanie, Centio, Anders, Estruch, Montserrat, Våtsveen, Thea Kristin, Struyf, Nona, Visnes, Torkild, Scobie, Martin, Koolmeister, Tobias, Henriksson, Martin, Wallner, Olov, Sandvall, Teresa, Lehmann, Sören, Theilgaard-Mönch, Kim, Garnett, Mathew J, Östling, Päivi, Walfridsson, Julian, Helleday, Thomas, Warpman Berglund, Ulrika

“…Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high levels of reactive oxygen species (ROS). ROS levels have been suggested…”
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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors by Llona-Minguez, Sabin, Höglund, Andreas, Ghassemian, Artin, Desroses, Matthieu, Calderón-Montaño, José Manuel, Burgos Morón, Estefanía, Valerie, Nicholas C. K, Wiita, Elisee, Almlöf, Ingrid, Koolmeister, Tobias, Mateus, André, Cazares-Körner, Cindy, Sanjiv, Kumar, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Darabi, Masoud, Mehdizadeh, Amir, Fayezi, Shabnam, Jemth, Ann-Sofie, Warpman Berglund, Ulrika, Sigmundsson, Kristmundur, Lundbäck, Thomas, Jenmalm Jensen, Annika, Artursson, Per, Scobie, Martin, Helleday, Thomas

“…The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool “housekeeping” enzyme responsible for the catabolism of canonical and noncanonical nucleoside…”
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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions by Orta, Manuel Luis, Höglund, Andreas, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Burgos-Morón, Estefanía, Visnes, Torkild, Pastor, Nuria, Ström, Cecilia, López-lázaro, Miguel, Helleday, Thomas

“…Decitabine (5-aza-2'-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of…”
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Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1 by Llona-Minguez, Sabin, Höglund, Andreas, Wiita, Elisee, Almlöf, Ingrid, Mateus, André, Calderón-Montaño, José Manuel, Cazares-Körner, Cindy, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Jemth, Ann-Sofie, Häggblad, Maria, Martens, Ulf, Lundgren, Bo, Artursson, Per, Lundbäck, Thomas, Jenmalm Jensen, Annika, Warpman Berglund, Ulrika, Scobie, Martin, Helleday, Thomas

“…The dCTP pyrophosphatase 1 (dCTPase) is involved in the regulation of the cellular dNTP pool and has been linked to cancer progression. Here we report on the…”
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Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition by Höglund, Andreas, Strömvall, Kerstin, Li, Yongmei, Forshell, Linus Plym, Nilsson, Jonas A.

“…Myc is a transcription factor frequently found deregulated in human cancer. The Myc-mediated cellular transformation process is associated with fast…”
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Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 by Pudelko, Linda, Rouhi, Pegah, Sanjiv, Kumar, Gad, Helge, Kalderén, Christina, Höglund, Andreas, Squatrito, Massimo, Schuhmacher, Alberto J, Edwards, Steven, Hägerstrand, Daniel, Berglund, Ulrika Warpman, Helleday, Thomas, Bräutigam, Lars

“…Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with poor prognosis. Cancer cells are characterized by a specific redox environment that…”
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Overview of 3GPP Release 14 Enhanced NB-IoT by Hoglund, Andreas, Xingqin Lin, Liberg, Olof, Behravan, Ali, Yavuz, Emre A., Van Der Zee, Martin, Yutao Sui, Tirronen, Tuomas, Ratilainen, Antti, Eriksson, David

“…In 3GPP LTE Release 13, Narrowband Internet of Things (NB-IoT) was standardized for providing wide-area connectivity for massive machine-type communications…”
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5G Reduced Capability Devices: Analysis of Blocking Probability for Control Channels by Moloudi, Saeedeh, Mozaffari, Mohammad, Kittichokechai, Kittipong, Hoglund, Andreas, Kadan Veedu, Sandeep Narayanan, Eric Wang, Y.-P., Bergman, Johan

“…The fifth-generation wireless technology is primarily designed to address a wide range of use cases mainly categorized into the enhanced mobile broadband,…”
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool by Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A., Ström, Cecilia E., Svensson, Linda M., Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P.-A., Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J., Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z., Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S. A., Wallner, Olov A., Hammarström, Lars G. J., Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Puigvert, Jordi Carreras, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jensen, Annika Jenmalm, Artursson, Per, Nilsson, Jonas A., Stenmark, Pål, Scobie, Martin, Berglund, Ulrika Warpman, Helleday, Thomas

“…Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes…”
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Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine by Höglund, Andreas, Nilsson, Lisa M., Forshell, Linus Plym, Maclean, Kirsteen H., Nilsson, Jonas A.

“…Decitabine (also referred to as 5-aza-2′-deoxycytidine) is a drug that has recently been approved by the Food and Drug Administration (FDA) for the treatment…”
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Elasticity model for the evaluation of structural parameters in multilayer systems with applications to transition metal and Si-based multilayers by Råsander, Mikael, Souvatzis, Petros, Höglund, Andreas, Eriksson, Olle

“…In this paper we present and evaluate a model based on elasticity theory for the calculation of in- and out-of-plane lattice parameters in multilayer systems,…”
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Chemical strategies for development of ATR inhibitors by Llona-Minguez, Sabin, Höglund, Andreas, Jacques, Sylvain A, Koolmeister, Tobias, Helleday, Thomas

“…ATR protein kinase is one of the key players in maintaining genome integrity and coordinating of the DNA damage response and repair signalling pathways…”
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Novel Random Access Schemes for Small Data Transmission by Zhou, Hui, Deng, Yansha, Feltrin, Luca, Hoglund, Andreas, Dohler, Mischa

“…Fifth Generation (5G) New Radio (NR) does not support data transmission during random access (RA) procedures, which results in unnecessary control signalling…”
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Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors by Llona-Minguez, Sabin, Höglund, Andreas, Ghassemian, Artin, Desroses, Matthieu, Calderón-Montaño, José Manuel, Burgos Morón, Estefanía, Valerie, Nicholas C. K, Wiita, Elisee, Almlöf, Ingrid, Koolmeister, Tobias, Mateus, André, Cazares-Körner, Cindy, Sanjiv, Kumar, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Darabi, Masoud, Mehdizadeh, Amir, Fayezi, Shabnam, Jemth, Ann-Sofie, Warpman Berglund, Ulrika, Sigmundsson, Kristmundur, Lundbäck, Thomas, Jenmalm Jensen, Annika, Artursson, Per, Scobie, Martin, Helleday, Thomas

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Inhibition of cellular FLICE-like inhibitory protein abolishes insensitivity to interferon-α and death receptor stimulation in resistant variants of the human U937 cell line by Blomberg, Jeanette, Höglund, Andreas, Eriksson, David, Ruuth, Kristina, Jacobsson, Maria, Lundgren, Erik, Nilsson, Jonas A.

“…Type I interferons constitute a family of pleiotropic cytokines that have a key role in both adaptive and innate immunity. The interferon signalling pathways…”
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