Search Results - "Hogarth, Mark P."

Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond by Hogarth, P. Mark, Pietersz, Geoffrey A.

“…Key Points Antibodies produced by the humoral arm of the adaptive immune system induce powerful effector responses of the innate immune system. Many of these…”
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Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence by Hartley, Gemma E, Edwards, Emily S J, Aui, Pei M, Varese, Nirupama, Stojanovic, Stephanie, McMahon, James, Peleg, Anton Y, Boo, Irene, Drummer, Heidi E, Hogarth, P Mark, O'Hehir, Robyn E, van Zelm, Menno C

“…Lasting immunity following SARS-CoV-2 infection is questioned because serum antibodies decline in convalescence. However, functional immunity is mediated by…”
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The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease by Anania, Jessica C, Chenoweth, Alicia M, Wines, Bruce D, Hogarth, P Mark

“…FcγRs have been the focus of extensive research due to their key role linking innate and humoral immunity and their implication in both inflammatory and…”
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Mechanisms and targets of Fcγ-receptor mediated immunity to malaria sporozoites by Feng, Gaoqian, Wines, Bruce D., Kurtovic, Liriye, Chan, Jo-Anne, Boeuf, Philippe, Mollard, Vanessa, Cozijnsen, Anton, Drew, Damien R., Center, Rob J., Marshall, Daniel L., Chishimba, Sandra, McFadden, Geoffrey I., Dent, Arlene E., Chelimo, Kiprotich, Boyle, Michelle J., Kazura, James W., Hogarth, P. Mark, Beeson, James G.

“…A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of antibody-mediated immunity is…”
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Harnessing the immune system via FcγR function in immune therapy: a pathway to next‐gen mAbs by Chenoweth, Alicia M, Wines, Bruce D, Anania, Jessica C, Mark Hogarth, P

“…The human fragment crystallizable (Fc)γ receptor (R) interacts with antigen‐complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful…”
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Antibody-Dependent Cellular Cytotoxicity Responses to Seasonal Influenza Vaccination in Older Adults by Vanderven, Hillary A, Jegaskanda, Sinthujan, Wines, Bruce D, Hogarth, P Mark, Carmuglia, Sarina, Rockman, Steven, Chung, Amy W, Kent, Stephen J

“…In older adults, the antibody-dependent cellular cytotoxicity (ADCC) response to seasonal trivalent influenza vaccination mirrored the hemagglutination…”
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HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV by Madhavi, Vijaya, Wines, Bruce D, Amin, Janaki, Emery, Sean, Lopez, Ester, Kelleher, Anthony, Center, Rob J, Hogarth, P Mark, Chung, Amy W, Kent, Stephen J, Stratov, Ivan

“…Studying HIV-infected individuals who control HIV replication (elite controllers [ECs]) enables exploration of effective anti-HIV immunity. HIV Env-specific…”
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Dimeric Fcγ Receptor Enzyme-Linked Immunosorbent Assay To Study HIV-Specific Antibodies: A New Look into Breadth of Fcγ Receptor Antibodies Induced by the RV144 Vaccine Trial by McLean, Milla R, Madhavi, Vijaya, Wines, Bruce D, Hogarth, P Mark, Chung, Amy W, Kent, Stephen J

“…Ab-dependent cellular cytotoxicity (ADCC) responses are of growing interest in the HIV vaccine field but current cell-based assays are usually difficult to…”
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Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells by Anand, Sai Priya, Prévost, Jérémie, Baril, Sophie, Richard, Jonathan, Medjahed, Halima, Chapleau, Jean-Philippe, Tolbert, William D, Kirk, Sharon, Smith, 3rd, Amos B, Wines, Bruce D, Kent, Stephen J, Hogarth, P Mark, Parsons, Matthew S, Pazgier, Marzena, Finzi, Andrés

“…HIV-1 conceals epitopes of its envelope glycoproteins (Env) recognized by antibody (Ab)-dependent cellular cytotoxicity (ADCC)-mediating antibodies. These Abs,…”
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Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria by Aitken, Elizabeth H, Damelang, Timon, Ortega-Pajares, Amaya, Alemu, Agersew, Hasang, Wina, Dini, Saber, Unger, Holger W, Ome-Kaius, Maria, Nielsen, Morten A, Salanti, Ali, Smith, Joe, Kent, Stephen, Hogarth, P Mark, Wines, Bruce D, Simpson, Julie A, Chung, Amy, Rogerson, Stephen J

“…Background: Plasmodium falciparum causes placental malaria, which results in adverse outcomes for mother and child. P. falciparum -infected erythrocytes that…”
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Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions by Lopez, Ester, Scott, Nichollas E, Wines, Bruce D, Hogarth, P Mark, Wheatley, Adam K, Kent, Stephen J, Chung, Amy W

“…Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and autoimmunity research cohorts,…”
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Fc functional antibodies in humans with severe H7N9 and seasonal influenza by Vanderven, Hillary A, Liu, Lu, Ana-Sosa-Batiz, Fernanda, Nguyen, Thi Ho, Wan, Yanmin, Wines, Bruce, Hogarth, P Mark, Tilmanis, Danielle, Reynaldi, Arnold, Parsons, Matthew S, Hurt, Aeron C, Davenport, Miles P, Kotsimbos, Tom, Cheng, Allen C, Kedzierska, Katherine, Zhang, Xiaoyan, Xu, Jianqing, Kent, Stephen J

“…Both seasonal and novel avian influenza viruses can result in severe infections requiring hospitalization. Anti-influenza antibodies (Abs) with Fc-mediated…”
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Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians by Hensen, Luca, Nguyen, Thi H. O., Rowntree, Louise C., Damelang, Timon, Koutsakos, Marios, Aban, Malet, Hurt, Aeron, Harland, Kim L., Auladell, Maria, van de Sandt, Carolien E., Everitt, Anngie, Blacker, Cath, Oyong, Damian A., Loughland, Jessica R., Webb, Jessica R., Wines, Bruce D., Hogarth, P. Mark, Flanagan, Katie L., Plebanski, Magdalena, Wheatley, Adam, Chung, Amy W., Kent, Stephen J., Miller, Adrian, Clemens, E. Bridie, Doherty, Peter C., Nelson, Jane, Davies, Jane, Tong, Steven Y. C., Kedzierska, Katherine

“…Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigenous people globally. Although…”
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Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children by Feng, Gaoqian, Kurtovic, Liriye, Agius, Paul A, Aitken, Elizabeth H, Sacarlal, Jahit, Wines, Bruce D, Hogarth, P. Mark, Rogerson, Stephen J, Fowkes, Freya J. I, Dobaéo, Carlota, Beeson, James G

“…Abstract Background RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, vaccine efficacy is modest and…”
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Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases by Yap, May Lin, McFadyen, James D, Wang, Xiaowei, Ziegler, Melanie, Chen, Yung-Chih, Willcox, Abbey, Nowell, Cameron J, Scott, Andrew M, Sloan, Erica K, Hogarth, P Mark, Pietersz, Geoffrey A, Peter, Karlheinz

“…: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypothesizing that activated platelets in the tumor microenvironment…”
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Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children by Chan, Jo-Anne, Loughland, Jessica R., de la Parte, Lauren, Okano, Satomi, Ssewanyana, Isaac, Nalubega, Mayimuna, Nankya, Felistas, Musinguzi, Kenneth, Rek, John, Arinaitwe, Emmanuel, Tipping, Peta, Bourke, Peter, Andrew, Dean, Dooley, Nicholas, SheelaNair, Arya, Wines, Bruce D., Hogarth, P. Mark, Beeson, James G., Greenhouse, Bryan, Dorsey, Grant, Kamya, Moses, Hartel, Gunter, Minigo, Gabriela, Feeney, Margaret, Jagannathan, Prasanna, Boyle, Michelle J.

“…T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However, little is known regarding the host and parasite factors that…”
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Enhancement of Antibody-Dependent Cellular Cytotoxicity and Phagocytosis in Anti-HIV-1 Human-Bovine Chimeric Broadly Neutralizing Antibodies by Edwards, Jack M, Heydarchi, Behnaz, Khoury, Georges, Salazar-Quiroz, Natalia A, Gonelli, Christopher A, Wines, Bruce, Hogarth, P Mark, Kristensen, Anne B, Parsons, Matthew S, Purcell, Damian F J

“…No prophylactic vaccine has provided robust protection against human immunodeficiency virus type 1 (HIV-1). Vaccine-induced broadly neutralizing antibodies…”
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Context-restricted PD-(L)1 checkpoint agonism by CTLA4-Ig therapies inhibits T cell activity by Oxley, Ethan P., Kershaw, Nadia J., Louis, Cynthia, Goodall, Katharine J., Garwood, Maximilian M., Jee Ho, Skye Min, Voo, Veronica T.F., Park, Hae-Young, Iaria, Josephine, Wong, Lilian L.L., Lebenbaum, Ariel G., Wiranata, Stephanie, Pang, Ee Shan, Edwards, Emily S.J., D’Silva, Damian B., Hansen, Jacinta, van Zelm, Menno C., O’Keeffe, Meredith, Hogarth, P. Mark, Haynes, Nicole M., Huntington, Nicholas D., Wicks, Ian P., Dickins, Ross A.

“…T cell surface CTLA4 sequesters the costimulatory ligands CD80 and CD86 on antigen-presenting cells (APCs) to prevent autoimmunity. Therapeutic…”
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Decay of Fc-dependent antibody functions after mild to moderate COVID-19 by Lee, Wen Shi, Selva, Kevin John, Davis, Samantha K., Wines, Bruce D., Reynaldi, Arnold, Esterbauer, Robyn, Kelly, Hannah G., Haycroft, Ebene R., Tan, Hyon-Xhi, Juno, Jennifer A., Wheatley, Adam K., Hogarth, P. Mark, Cromer, Deborah, Davenport, Miles P., Chung, Amy W., Kent, Stephen J.

“…The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectious diseases. The evolution of…”
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Antibody Functional Assays as Measures of Fc Receptor-Mediated Immunity to HIV - New Technologies and their Impact on the HIV Vaccine Field by Wines, Bruce D, Billings, Hugh, Mclean, Milla R, Kent, Stephen J, Hogarth, P Mark

“…There is now intense interest in the role of HIV-specific antibodies and the engagement of FcγR functions in the control and prevention of HIV infection. The…”
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