Search Results - "Hogan, K T"

The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated Elongation Factor 2 gene by HOGAN, K. T, EISINGER, D. P, CUPP, S. B, LEKSTROM, K. J, DEACON, D. D, SHABANOWITZ, J, HUNT, D. F, ENGELHARD, V. H, SLINGLUFF, C. L, ROSS, M. M

“…The identification of naturally processed tumor peptides that can stimulate a tumor-specific, CTL response is crucial to the development of a vaccine-based,…”
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Identification by site-directed mutagenesis of amino acid residues contributing to serologic and CTL-defined epitope differences between HLA-A2.1 and HLA-A2.3 by Hogan, KT, Clayberger, C, Bernhard, EJ, Walk, SF, Ridge, JP, Parham, P, Krensky, AM, Engelhard, VH

“…Site-directed mutagenesis of HLA-A2.1 has been used to identify the amino acid substitutions in HLA-A2.3 that are responsible for the lack of recognition of…”
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The ability of cytotoxic T cells to recognize HLA-A2.1 or HLA-B7 antigens expressed on murine cells correlates with their epitope specificity by Bernhard, EJ, Le, AX, Yannelli, JR, Holterman, MJ, Hogan, KT, Parham, P, Engelhard, VH

“…Two groups of human and murine cytotoxic T lymphocyte (CTL) clones specific for human leukocyte antigen (HLA)-A2 or -B7 can be distinguished based on their…”
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Localization and characterization of serologic epitopes on HLA-A2 by Hogan, K T, Brown, S L

“…A panel of cells expressing 68 different mutant HLA-A2 genes was generated by site-directed mutagenesis and DNA-mediated gene transfer in order to define the…”
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Residues outside of the HLA-A2 peptide-binding groove can abrogate or enhance recognition of influenza virus matrix peptide pulsed cells by cytotoxic T lymphocytes by Teng, J M, Hogan, K T

“…An examination of the crystal structure of HLA-A2.1 reveals two classes of residues on the class I MHC molecule that could affect CTL recognition: (1) those…”
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Use of selected reaction monitoring mass spectrometry for the detection of specific MHC class I peptide antigens on A3 supertype family members by HOGAN, Kevin T, SUTTON, Jennifer N, CHU, Kyo U, BUSBY, Jennifer A. C, SHABANOWITZ, Jeffrey, HUNT, Donald F, SLINGLUFF, Craig L

“…The development of peptide-based vaccines that are useful in the therapeutic treatment of melanoma and other cancers ultimately requires the identification of…”
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A panel of unique HLA-A2 mutant molecules define epitopes recognized by HLA-A2-specific antibodies and cytotoxic T lymphocytes by Hogan, KT, Clayberger, C, Bernhard, EJ, Walk, SF, Ridge, JP, Parham, P, Krensky, AM, Engelhard, VH

“…HLA-A2.1 and HLA-A2.3, which differ from one another at residues 149, 152, and 156, can be distinguished by the mAb CR11-351 and many allogeneic and xenogeneic…”
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Cytotoxic T lymphocyte-defined epitope differences between HLA-A2.1 and HLA-A2.2 map to two distinct regions of the molecule by Hogan, KT, Clayberger, C, Le, AX, Walk, SF, Ridge, JP, Parham, P, Krensky, AM, Engelhard, VH

“…Hemi-exon shuffling and site-directed mutagenesis have been used to determine which amino acid differences between HLA-A2.1 and HLA-A2.2 alter the CTL-defined…”
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Clonal analysis of the cytotoxic T-lymphocyte response to reovirus by Hogan, K T, Cashdollar, L W

“…Reovirus has previously been classified into three serotypes based on hemagglutination inhibition assays. In the present study, the specificity of cytotoxic T…”
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Epitope fine specificity of human anti-HLA-A2 antibodies by DeVito, L D, Hogan, K T, Mason, B P, Guo, J W, Lutz, C T, Sollinger, H W, Burlingham, W J

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A Class I MHC-Restricted Recall Response to a Viral Peptide Is Highly Polyclonal Despite Stringent CDR3 Selection: Implications for Establishing Memory T Cell Repertoires in "Real-World" Conditions by Naumov, Yuri N, Hogan, Kevin T, Naumova, Elena N, Pagel, Jeminah T, Gorski, Jack

“…In this study, we analyze the recall response to influenza A matrix peptide M1(58-66) restricted by HLA-A2 in one individual and find a strict CDR3 selection…”
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The reovirus nonstructural protein sigma1NS is recognized by murine cytotoxic T lymphocytes by Hoffman, L M, Hogan, K T, Cashdollar, L W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of a shared epitope recognized by melanoma-specific, HLA-A3-restricted cytotoxic T lymphocytes by Hogan, Kevin T., Coppola, Michael A., Gatlin, Christine L., Thompson, Lee W., Shabanowitz, Jeffrey, Hunt, Donald F., Engelhard, Victor H., Slingluff, Craig L., Ross, Mark M.

“…We previously established a melanoma-reactive cytotoxic T lymphocyte (CTL) line that recognizes multiple epitopes in the context of HLA-A3. To increase the…”
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Identification of class I MHC regions which bind to the adenovirus E3-19k protein by Flomenberg, P, Gutierrez, E, Hogan, K T

“…The adenovirus early region 3 glycoprotein E3-19k binds to and inhibits expression of class I major histocompatibility complex (MHC)-encoded molecules, which…”
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A Multipeptide Vaccine is Safe and Elicits T-cell Responses in Participants With Advanced Stage Ovarian Cancer by CHIANESE-BULLOCK, Kimberly A, IRVIN, William P, YUAN, Arlene, HOGAN, Kevin T, SLINGLUFF, Craig L, PETRONI, Gina R, MURPHY, Cheryl, SMOLKIN, Mark, OLSON, Walter C, COLEMAN, Elizabeth, BOERNER, Scott A, NAIL, Carmel J, NEESE, Patrice Y

“…Nine participants with epithelial ovarian, fallopian tube, or primary peritoneal carcinoma, who were human leukocyte antigen (HLA)-A1, HLA-A2, or HLA-A3, were…”
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Mutations in the alpha 2 helix of HLA-A2 affect presentation but do not inhibit binding of influenza virus matrix peptide by Hogan, K T, Shimojo, N, Walk, S F, Engelhard, V H, Maloy, W L, Coligan, J E, Biddison, W E

“…Previous studies have suggested that MHC class I molecules bind and present peptides to CTL in a manner that is analogous to the presentation of peptides by…”
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HLA (A0201) Mimicry by Anti-Idiotypic Monoclonal Antibodies by Burlingham, William J, Jankowska-Gan, Ewa, DeVito-Haynes, Lynn, Fechner, John H., Jr, Hogan, Kevin T, Claas, Frans H. J, Mulder, Arend, Wang, Xinhui, Ferrone, Soldano

“…Soluble MHC Ags and anti-Id (anti-anti-MHC) Abs have both been shown to inhibit MHC alloantigen-specific B cell responses in vivo. We hypothesized that some…”
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Both major and minor peptide-binding pockets in HLA-A2 influence the presentation of influenza virus matrix peptide to cytotoxic T lymphocytes by Teng, J M, Hogan, K T

“…Most of the polymorphic residues in class I MHC molecules are concentrated in the alpha 1- and alpha 2-domains with their side chains pointing towards the…”
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Suppression of polyclonal, tumor cell and alloantigen-induced proliferation: identification of cyclooxygenase pathway dependent and independent mechanisms by Hogan, K T, Hollingsworth, M A, Seymour, 3rd, R E, Quinn, M K, Evans, D L

“…Polyclonal T cell activation, syngeneic tumor cell and alloantigen-induced proliferative responses were studied to determine if the regulation of these…”
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Epitope fine specificity of human anti-HLA-A2 antibodies. Identification of four epitopes including a haptenlike epitope on HLA-A2 at lysine 127 by De Vito, L D, Mason, B P, Jankowska-Gan, E, Hogan, K T, Guo, J W, Lutz, C T, Sollinger, H W, Burlingham, W J

“…Anti-HLA-A2 CREG antibodies were purified from seven individuals by affinity chromatography. The binding of the purified antibodies to single or multiple amino…”
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