Search Results - "Hogaboam, CM"

The link between fungi and severe asthma: a summary of the evidence by Denning, D. W, O'Driscoll, B. R, Hogaboam, C. M, Bowyer, P, Niven, R. M

“…There is current evidence to demonstrate a close association between fungal sensitisation and asthma severity. Whether such an association is causal remains to…”
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Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages by Murray, Lynne A, Rosada, Rogerio, Moreira, Ana Paula, Joshi, Amrita, Kramer, Michael S, Hesson, David P, Argentieri, Rochelle L, Mathai, Susan, Gulati, Mridu, Herzog, Erica L, Hogaboam, Cory M

“…Macrophages promote tissue remodeling but few mechanisms exist to modulate their activity during tissue fibrosis. Serum amyloid P (SAP), a member of the…”
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Negative Regulation of Myofibroblast Differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) by White, Eric S, Atrasz, Rachelle G, Hu, Biao, Phan, Sem H, Stambolic, Vuk, Mak, Tak W, Hogaboam, Cory M, Flaherty, Kevin R, Martinez, Fernando J, Kontos, Christopher D, Toews, Galen B

“…Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF). Defining mechanisms of myofibroblast differentiation may be critical to the…”
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Reversal of long-term sepsis-induced immunosuppression by dendritic cells by Benjamim, Claudia F., Lundy, Steven K., Lukacs, Nicholas W., Hogaboam, Cory M., Kunkel, Steven L.

“…Severe sepsis leads to long-term systemic and local immunosuppression, which is the cause of a number of complications, including pulmonary infection. A…”
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Chemokines provide the sustained inflammatory bridge between innate and acquired immunity by Coelho, Ana L., Hogaboam, Cory M., Kunkel, Steven L.

“…In this review we focus on the role of chemokines in discreet areas of innate immunity and demonstrate that chemokines are key participants to not only the…”
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MIP-1α[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-α and LTB4 by Ramos, Cleber D. L., Canetti, Claudio, Souto, Janeusa T., Silva, João S., Hogaboam, Cory M., Ferreira, Sergio H., Cunha, Fernando Q.

“…In the present study, we investigated the involvement of macrophage‐inflammatory protein‐1α (MIP‐1α)[CC chemokine ligand 3 (CCL3)], MIP‐1β[CCL4], regulated on…”
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Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells by Jakubzick, Claudia, Choi, Esther S, Joshi, Bharat H, Keane, Michael P, Kunkel, Steven L, Puri, Raj K, Hogaboam, Cory M

“…Severe forms of idiopathic interstitial pneumonia (IIP), such as usual interstitial pneumonia, can be impervious to modern steroid and immunosuppressive…”
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CCL3/MIP‐1α is pro‐inflammatory in murine T cell‐mediated hepatitis by recruiting CCR1‐expressing CD4+ T cells to the liver by Ajuebor, Maureen N., Hogaboam, Cory M., Le, Tai, Proudfoot, Amanda E. I., Swain, Mark G.

“…T cell‐mediated hepatitis is associated with significant morbidity and mortality worldwide. Levels of C‐C chemokine ligand 3/macrophage inflammatory protein‐1α…”
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The chronic consequences of severe sepsis by Benjamim, Claudia F., Hogaboam, Cory M., Kunkel, Steven L.

“…The early events of severe sepsis set in motion a cascade of events that significantly contributes to the morbidity and mortality observed during the first few…”
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Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4‐/‐ mice by Schuh, Jane M., Power, Christine A., Proudfoot, Amanda E., Kunkel, Steven L., Lukacs, Nicholas W., Hogaboam, Cory M.

“…ABSTRACT The role of CC chemokine receptor 4 (CCR4) during the development and maintenance of Th2type allergic airway disease is controversial. In this study,…”
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Role of CCR4 Ligands, CCL17 and CCL22, During Schistosoma mansoni Egg-Induced Pulmonary Granuloma Formation in Mice by Jakubzick, Claudia, Wen, Haitao, Matsukawa, Akihiro, Keller, Maya, Kunkel, Steven L., Hogaboam, Cory M.

“…Controversy persists pertaining to the role of CCR4 ligands, namely CCL17 (or thymus and activation regulated chemokine; TARC) and CCL22 (or macrophage-derived…”
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Lack of Chemokine Receptor CCR5 Promotes Murine Fulminant Liver Failure by Preventing the Apoptosis of Activated CD1d-Restricted NKT Cells by Ajuebor, Maureen N, Aspinall, Alex I, Zhou, Feng, Le, Tai, Yang, Yang, Urbanski, Stefan J, Sidobre, Stephane, Kronenberg, Mitchell, Hogaboam, Cory M, Swain, Mark G

“…Fulminant liver failure (FLF) consists of a cascade of events beginning with a presumed uncontrolled systemic activation of the immune system. The etiology of…”
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Septic Mice Are Susceptible to Pulmonary Aspergillosis by Benjamim, Claudia F., Hogaboam, Cory M., Lukacs, Nicholas W., Kunkel, Steven L.

“…Clinical data underscores the fact that subsequent high mortality rates occur in patients who survive acute septic episodes. Herein, we described a clinically…”
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CCR1 and CC Chemokine Ligand 5 Interactions Exacerbate Innate Immune Responses during Sepsis by Ness, Traci L, Carpenter, Kristin J, Ewing, Jillian L, Gerard, Craig J, Hogaboam, Cory M, Kunkel, Steven L

“…CCR1 has previously been shown to play important roles in leukocyte trafficking, pathogen clearance, and the type 1/type 2 cytokine balance, although very…”
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Immunomodulatory Role of CXCR2 During Experimental Septic Peritonitis by Ness, Traci L, Hogaboam, Cory M, Strieter, Robert M, Kunkel, Steven L

“…The loss of CXCR2 expression by neutrophils is a well-described, but poorly understood, consequence of clinical sepsis. To address the potential impact of this…”
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Respiratory Syncytial Virus Predisposes Mice to Augmented Allergic Airway Responses Via IL-13-Mediated Mechanisms by Lukacs, Nicholas W, Tekkanat, Kim K, Berlin, Aaron, Hogaboam, Cory M, Miller, Allison, Evanoff, Holly, Lincoln, Pam, Maassab, Hussien

“…The development of severe childhood asthma may be influenced by several factors including environmental and infectious stimuli. The causal relationship between…”
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Therapeutic targeting of IL-4- and IL-13-responsive cells in pulmonary fibrosis by Jakubzick, Claudia, Kunkel, Steven L, Puri, Raj K, Hogaboam, Cory M

“…Severe forms of idiopathic interstitial pneumonia (IIP), such as usual interstitial pneumonia (UIP), can be impervious to modern steroid and immunosuppressive…”
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Therapeutic Effect of IL-13 Immunoneutralization During Chronic Experimental Fungal Asthma by Blease, Kate, Jakubzick, Claudia, Westwick, John, Lukacs, Nicholas, Kunkel, Steven L, Hogaboam, Cory M

“…IL-13 and IL-4 are key contributors to the asthmatic phenotype. The temporal role of these cytokines in airway function, inflammation, and remodeling were…”
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Enhanced Pulmonary Allergic Responses to Aspergillus in CCR2-/- Mice by Blease, Kate, Mehrad, Borna, Standiford, Theodore J, Lukacs, Nicholas W, Gosling, Jennifa, Boring, Landin, Charo, Israel F, Kunkel, Steven L, Hogaboam, Cory M

“…Allergic responses to Aspergillus species exacerbate asthma and cystic fibrosis. The natural defense against live Aspergillus fumigatus spores or conidia…”
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Reactive Nitrogen Species Augment Fibroblast-Mediated Collagen Gel Contraction, Mediator Production, and Chemotaxis by Sugiura, Hisatoshi, Liu, Xiangde, Kobayashi, Tetsu, Togo, Shinsaku, Ertl, Ronald F, Kawasaki, Shin, Kamio, Koichiro, Wang, Xing Qi, Mao, Lijun, Shen, Lei, Hogaboam, Cory M, Rennard, Stephen I

“…Reactive nitrogen species (RNS) such as peroxynitrite cause cellular injury and tissue inflammation. Excessive production of nitrotyrosine, which is a…”
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