Search Results - "Hofmann, Nicolle E"

Discovery and Characterization of Recurrent, Targetable ALK Fusions in Leiomyosarcoma by Davis, Lara E, Nusser, Kevin D, Przybyl, Joanna, Pittsenbarger, Janét, Hofmann, Nicolle E, Varma, Sushama, Vennam, Sujay, Debiec-Rychter, Maria, van de Rijn, Matt, Davare, Monika A

“…Soft-tissue sarcomas such as leiomyosarcoma pose a clinical challenge because systemic treatment options show only modest therapeutic benefit. Discovery and…”
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NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors by Somwar, Romel, Hofmann, Nicolle E., Smith, Bryan, Odintsov, Igor, Vojnic, Morana, Linkov, Irina, Tam, Ashley, Khodos, Inna, Mattar, Marissa S., de Stanchina, Elisa, Flynn, Daniel, Ladanyi, Marc, Drilon, Alexander, Shinde, Ujwal, Davare, Monika A.

“…Tyrosine kinase domains dynamically fluctuate between two main structural forms that are referred to as type I (DFG-in) or type II (DFG-out) conformations…”
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Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC‐amplified model cell line by Henderson, Jacob J., Wagner, Jacob P., Hofmann, Nicolle E., Eide, Christopher A., Cho, Yoon‐Jae, Druker, Brian J., Davare, Monika A.

“…Medulloblastoma is the most common malignant brain tumor of childhood. To identify targetable vulnerabilities, we employed inhibitor screening that revealed…”
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A case study of personalized therapy for osteosarcoma by Davis, Lara E., Hofmann, Nicolle E., Li, Guangheng, Huang, Elaine T., Loriaux, Marc M., Bracha, Shay, Helfand, Stuart C., Mata, John E., Marley, Kevin, Mansoor, Atiya, Tyner, Jeffrey W., Abraham, Jinu, Séguin, Bernard, Keller, Charles

“…Background Effective targeted therapies are needed in sarcomas, but the biological heterogeneity of these tumors has presented a challenge to clinical…”
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Ferrets (Mustela putoius furo) inefficiently convert beta-carotene to vitamin A by Lederman, J D, Overton, K M, Hofmann, N E, Moore, B J, Thornton, J, Erdman, J W

“…The ferret has recently been used as a model to evaluate the absorption and metabolism of several carotenoids; however, little is known about the vitamin A…”
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The mongolian gerbil (Meriones unguiculatus) is an appropriate animal model for evaluation of the conversion of beta-carotene to vitamin A by Lee, C M, Lederman, J D, Hofmann, N E, Erdman, J W

“…Vitamin A (VA) deficiency is the leading cause of blindness in children in developing countries. Dietary intervention with foods rich in provitamin A…”
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All-trans beta-carotene is absorbed preferentially to 9-cis beta-carotene, but the latter accumulates in the tissues of domestic ferrets (Mustela putorius puro) by Erdman, Jr, J W, Thatcher, A J, Hofmann, N E, Lederman, J D, Block, S S, Lee, C M, Mokady, S

“…The algae Dunaliella bardawil and Dunaliella salina naturally contain large concentrations of all-trans and 9-cis beta-carotene (betaC). The purpose of this…”
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