Search Results - "Hofmann, Björn B."

Reproducibility and across-site transferability of an improved deep learning approach for aneurysm detection and segmentation in time-of-flight MR-angiograms by Vach, Marius, Wolf, Luisa, Weiss, Daniel, Ivan, Vivien Lorena, Hofmann, Björn B., Himmelspach, Ludmila, Caspers, Julian, Rubbert, Christian

“…This study aimed to (1) replicate a deep-learning-based model for cerebral aneurysm segmentation in TOF-MRAs, (2) improve the approach by testing various fully…”
Get full text

Prognostic value of platelet levels in patients with aneurysmal Subarachnoid Hemorrhage by Fischer, Igor, Lala, Ronahi, Donaldson, Daniel M., Schieferdecker, Simon, Hofmann, Björn B., Cornelius, Jan Frederick, Muhammad, Sajjad

“…Pathophysiological processes following aneurysmal subarachnoid hemorrhage (aSAH) include upregulated underlying systemic inflammation, which is reflected by…”
Get full text

Analyses of Synthetic N‑Acyl Dopamine Derivatives Revealing Different Structural Requirements for Their Anti-inflammatory and Transient-Receptor-Potential-Channel-of-the-Vanilloid-Receptor-Subfamily-Subtype‑1 (TRPV1)-Activating Properties by Pallavi, Prama, Pretze, Marc, Caballero, Julio, Li, Yingchun, Hofmann, Björn B, Stamellou, Eleni, Klotz, Sarah, Wängler, Carmen, Wängler, Björn, Loesel, Ralf, Roth, Steffen, Theisinger, Bastian, Moerz, Handan, Binzen, Uta, Greffrath, Wolfgang, Treede, Rolf-Detlef, Harmsen, Martin C, Krämer, Bernhard K, Hafner, Mathias, Yard, Benito A, Kälsch, Anna-Isabelle

“…We studied the chemical entities within N-octanoyl dopamine (NOD) responsible for the activation of transient-receptor-potential channels of the…”
Get full text

Evaluation of MTT Heterogeneity of Perfusion CT Imaging in the Early Brain Injury Phase: An Insight into aSAH Pathopysiology by Hofmann, Björn B, Fischer, Igor, Donaldson, Daniel M, Abusabha, Yousef, Karadag, Cihat, Muhammad, Sajjad, Beseoglu, Kerim, Hänggi, Daniel, Turowski, Bernd, Rubbert, Christian, Cornelius, Jan F, Kamp, Marcel A

“…The concept of early brain injury (EBI) is based on the assumption of a global reduction in brain perfusion following aneurysmal subarachnoid hemorrhage…”
Get full text

Novel Insights into Pathophysiology of Delayed Cerebral Ischemia: Effects of Current Rescue Therapy on Microvascular Perfusion Heterogeneity by Hofmann, Björn B, Karadag, Cihat, Rubbert, Christian, Schieferdecker, Simon, Neyazi, Milad, Abusabha, Yousef, Fischer, Igor, Boogaarts, Hieronymus D, Muhammad, Sajjad, Beseoglu, Kerim, Hänggi, Daniel, Turowski, Bernd, Kamp, Marcel A, Cornelius, Jan F

“…General microvascular perfusion and its heterogeneity are pathophysiological features of delayed cerebral ischemia (DCI) that are gaining increasing attention…”
Get full text

Cerebral Autoregulation: Don’t go with the Flow, be the Flow; Author′s Response by Hofmann, Björn B., Rubbert, Christian, Beseoglu, Kerim

“…Dear editor, We would like to thank Ayasse et al. for their interest in our article “Blood Pressure Affects the Early CT Perfusion Imaging in Patients with…”
Get full text

Validation of prognostic stroke scores—comments on “Evaluation of FRESH scores in predicting outcome and quality of life after aneurysmal subarachnoid haemorrhage in a European patient cohort”: Author’s response by Hofmann, Björn B., Kram, Rainer, Beseoglu, Kerim, Cornelius, Jan F.

Get full text

Blood Pressure Affects the Early CT Perfusion Imaging in Patients with aSAH Reflecting Early Disturbed Autoregulation by Hofmann, Björn B., Donaldson, Daniel M., Fischer, Igor, Karadag, Cihat, Neyazi, Milad, Piedade, Guilherme S., Abusabha, Yousef, Muhammad, Sajjad, Rubbert, Christian, Hänggi, Daniel, Beseoglu, Kerim

“…Background Early computed tomography perfusion (CTP) is frequently used to predict delayed cerebral ischemia following aneurysmatic subarachnoid hemorrhage…”
Get full text

Evaluation of FRESH scores in predicting outcome and quality of life after aneurysmal subarachnoid haemorrhage in a European patient cohort by Hofmann, Björn B., Gundlach, Evgenia P., Fischer, Igor, Muhammad, Sajjad, Kram, Rainer, Beseoglu, Kerim, Cornelius, Jan F.

“…Background Despite aneurysmal subarachnoid haemorrhage (aSAH) patients often experiencing physical and mental disabilities impacting their quality of life…”
Get full text

Revisiting the WFNS Score: Native Computed Tomography Imaging Improves Identification of Patients With "False Poor Grade" Aneurysmal Subarachnoid Hemorrhage by Hofmann, Björn B, Fischer, Igor, Neyazi, Milad, Karadag, Cihat, Donaldson, Daniel M, Abusabha, Yousef, Muhammad, Sajjad, Beseoglu, Kerim, Cornelius, Jan F, Hänggi, Daniel

“…In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), the optimal time to determine the World Federation of Neurosurgical Societies (WFNS)…”
Get full text

Clinical Outcome Prediction of Early Brain Injury in Aneurysmal Subarachnoid Hemorrhage: the SHELTER-Score by Hofmann, Björn B., Donaldson, Daniel M., Neyazi, Milad, Abusabha, Yousef, Beseoglu, Kerim, Hänggi, Daniel, Cornelius, Jan F., Fischer, Igor, Muhammad, Sajjad

“…Background Despite intensive research on preventing and treating vasospasm and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage (aSAH),…”
Get full text

Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells by Braun, Jana D., Pastene, Diego O., Breedijk, Annette, Rodriguez, Angelica, Hofmann, Björn B., Sticht, Carsten, von Ochsenstein, Elke, Allgayer, Heike, van den Born, Jacob, Bakker, Stephan, Hauske, Sibylle J., Krämer, Bernhard K., Yard, Benito A., Albrecht, Thomas

“…Although methylglyoxal (MGO) has emerged as key mediator of diabetic microvascular complications, the influence of MGO on the vascular transcriptome has not…”
Get full text

Meta-review on Perforation Model of Subarachnoid Hemorrhage in Mice: Filament Material as a Possible Moderator of Mortality by Alpdogan, Serdar, Sander, Timo, Zhang, Rui, Khan, Dilaware, Li, Xuanchen, Zhou, Huakang, Li, Ke, Nickel, Ann-Christin, Zheng, Baolong, Skryabin, Anastasiya, Schieferdecker, Simon, Hofmann, Björn B., Donaldson, Daniel Maximilian, Cornelius, Jan Frederick, Hänggi, Daniel, Muhammad, Sajjad

“…Robust preclinical models are inevitable for researchers to unravel pathomechanisms of subarachnoidal hemorrhage (SAH). For the mouse perforation model of SAH,…”
Get full text

The rupture of an anterior communicating artery aneurysm does not associate with an asymmetry in the A1 or A2 arteries: a retrospective study of radiological features by Wetzel-Yalelis, Andreas, Karadag, Cihat, Li, Lan, Turowski, Bernd, Bostelmann, Richard, Abusabha, Yousef, Hofmann, Björn B., Gousias, Konstantinos, Agrawal, Rachit, König, Matthias, Kaiser, Marga, Mijderwijk, Hendrik-Jan, Petridis, Athanasios K.

“…Although the formation and rupture risk of an anterior communicating artery (ACoA) aneurysm has been the subject of many studies, no previous study has…”
Get full text

Asymmetry of P1 and vertebral arteries is not related to basilar tip aneurysm development or rupture by Li, Lan, Hofmann, Björn B., Fischer, Igor, Donaldson, Daniel M., Engel, Adrian, Karadag, Cihat, Wetzel-Yalelis, Andreas, Piedade, Guilherme Santos, Mijderwijk, Hendrik-Jan, Bostelmann, Richard, Kaschner, Marius G., Muhammad, Sajjad, Hänggi, Daniel, Cornelius, Jan F., Petridis, Athanasios K.

“…Objective Lately, morphological parameters of the surrounding vasculature aside from aneurysm size, specific for the aneurysm location, e.g., posterior…”
Get full text

Initial Temporal Muscle Thickness and Area: Poor Predictors of Neurological Outcome in Aneurysmal Subarachnoid Hemorrhage in a Central European Patient Cohort by Karadag, Cihat, Kamp, Marcel A, Fischer, Igor, Boogaarts, Hieronymus D, Beseoglu, Kerim, Muhammad, Sajjad, Cornelius, Jan F, Hofmann, Björn B

“…The temporalis muscle area (TMA) has been proclaimed as a surrogate parameter for estimating skeletal muscle mass. Pilot studies in Asian populations suggested…”
Get full text

N-Octanoyl-Dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells by Hofmann, Björn B., Krapp, Nicolas, Li, Yingchun, De La Torre, Carolina, Sol, Marloes, Braun, Jana D., Kolibabka, Matthias, Pallavi, Prama, Krämer, Bernhard K., Yard, Benito A., Kälsch, Anna-Isabelle

“…IFNγ enhances allograft immunogenicity and facilitates T-cell mediated rejection. This may cause interstitial fibrosis and tubular atrophy (IFTA), contributing…”
Get full text

Cerebral Autoregulation: Don't go with the Flow, be the Flow; Author's Response by Hofmann, Björn B, Rubbert, Christian, Beseoglu, Kerim

Get full text