Search Results - "Hofman, Jakub"

Biochar surface functional groups as affected by biomass feedstock, biochar composition and pyrolysis temperature by Janu, Rainer, Mrlik, Verena, Ribitsch, Doris, Hofman, Jakub, Sedláček, Petr, Bielská, Lucie, Soja, Gerhard

“…[Display omitted] •Basic physico-chemical biochar characteristics determine FTIR spectra.•Multiple regression models and Principal Component Analyses can…”
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Distribution of pesticides in agroecosystem food webs differ among trophic groups and between annual and perennial crops by Michalko, Radek, Purchart, Luboš, Hofman, Jakub, Košulič, Ondřej

“…Pesticides threaten biodiversity, but we know little about how they permeate food webs. Few studies have investigated the number, concentration, and…”
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Anthracycline resistance mediated by reductive metabolism in cancer cells: The role of aldo-keto reductase 1C3 by Hofman, Jakub, Malcekova, Beata, Skarka, Adam, Novotna, Eva, Wsol, Vladimir

“…Pharmacokinetic drug resistance is a serious obstacle that emerges during cancer chemotherapy. In this study, we investigated the possible role of aldo-keto…”
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Talazoparib Does Not Interact with ABCB1 Transporter or Cytochrome P450s, but Modulates Multidrug Resistance Mediated by ABCC1 and ABCG2: An in Vitro and Ex Vivo Study by Sabet, Ziba, Vagiannis, Dimitrios, Budagaga, Youssif, Zhang, Yu, Novotná, Eva, Hanke, Ivo, Rozkoš, Tomáš, Hofman, Jakub

“…Talazoparib (Talzenna) is a novel poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitor that is clinically used for the therapy of breast cancer…”
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Fate and bioavailability of four conazole fungicides in twelve different arable soils – Effects of soil and pesticide properties by Šudoma, Marek, Neuwirthová, Natália, Hvězdová, Martina, Svobodová, Markéta, Bílková, Zuzana, Scherr, Kerstin E., Hofman, Jakub

“…The objective of this study is to characterize changes in the fate, behaviour and bioavailability of four conazole fungicides - CFs (prochloraz - PRO,…”
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Pesticide residues with hazard classifications relevant to non-target species including humans are omnipresent in the environment and farmer residences by Silva, Vera, Gai, Lingtong, Harkes, Paula, Tan, Gaowei, Ritsema, Coen J., Alcon, Francisco, Contreras, Josefa, Abrantes, Nelson, Campos, Isabel, Baldi, Isabelle, Bureau, Mathilde, Christ, Florian, Mandrioli, Daniele, Sgargi, Daria, Pasković, Igor, Polić Pasković, Marija, Glavan, Matjaž, Hofman, Jakub, Huerta Lwanga, Esperanza, Norgaard, Trine, Bílková, Zuzana, Osman, Rima, Khurshid, Chrow, Navarro, Irene, de la Torre, Adrián, Sanz, Paloma, Ángeles Martínez, María, Dias, Jonatan, Mol, Hans, Gort, Gerrit, Martins Figueiredo, Daniel, Scheepers, Paul T.J., Schlünssen, Vivi, Vested, Anne, Alaoui, Abdallah, Geissen, Violette

“…Intensive and widespread use of pesticides raises serious environmental and human health concerns. The presence and levels of 209 pesticide residues (active…”
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Collection of human and environmental data on pesticide use in Europe and Argentina: Field study protocol for the SPRINT project by Silva, Vera, Alaoui, Abdallah, Schlünssen, Vivi, Vested, Anne, Graumans, Martien, van Dael, Maurice, Trevisan, Marco, Suciu, Nicoleta, Mol, Hans, Beekmann, Karsten, Figueiredo, Daniel, Harkes, Paula, Hofman, Jakub, Kandeler, Ellen, Abrantes, Nelson, Campos, Isabel, Martínez, María Ángeles, Pereira, Joana Luísa, Goossens, Dirk, Gandrass, Juergen, Debler, Freya, Lwanga, Esperanza Huerta, Jonker, Marlot, van Langevelde, Frank, Sorensen, Martin T, Wells, Jerry M, Boekhorst, Jos, Huss, Anke, Mandrioli, Daniele, Sgargi, Daria, Nathanail, Paul, Nathanail, Judith, Tamm, Lucius, Fantke, Peter, Mark, Jennifer, Grovermann, Christian, Frelih-Larsen, Ana, Herb, Irina, Chivers, Charlotte-Anne, Mills, Jane, Alcon, Francisco, Contreras, Josefina, Baldi, Isabelle, Pasković, Igor, Matjaz, Glavan, Norgaard, Trine, Aparicio, Virginia, Ritsema, Coen J, Geissen, Violette, Scheepers, Paul T J

“…Current farm systems rely on the use of Plant Protection Products (PPP) to secure high productivity and control threats to the quality of the crops. However,…”
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Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro by Cihalova, Daniela, Hofman, Jakub, Ceckova, Martina, Staud, Frantisek

“…Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially…”
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Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo by Vagiannis, Dimitrios, Budagaga, Youssif, Morell, Anselm, Zhang, Yu, Novotná, Eva, Skarka, Adam, Kammerer, Sarah, Küpper, Jan-Heiner, Hanke, Ivo, Rozkoš, Tomáš, Hofman, Jakub

“…Tepotinib is a novel tyrosine kinase inhibitor recently approved for the treatment of non-small cell lung cancer (NSCLC). In this study, we evaluated the…”
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Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens? by Novotná, Eva, Morell, Anselm, Büküm, Neslihan, Hofman, Jakub, Danielisová, Petra, Wsól, Vladimír

“…Although novel anticancer drugs are being developed intensively, anthracyclines remain the gold standard in the treatment of acute myeloid leukaemia (AML). The…”
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Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility by Cygalova, Lenka Hahnova, Hofman, Jakub, Ceckova, Martina, Staud, Frantisek

“…Breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp) are the most abundantly expressed ATP-binding cassette (ABC) drug transporters in the…”
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Nano-enabled pesticides: a comprehensive toxicity assessment of tebuconazole nanoformulations with nematodes at single species and community level by Eghbalinejad, Mahleh, Hofman, Jakub, Kotouček, Jan, Grillo, Renato, Hochmanová Bílková, Zuzana, Reiff, Nicola, Höss, Sebastian

“…There is an increasing imperative to explore safer alternatives for pesticides due to their indiscriminate use and consequential health impacts on the…”
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Effects of biochar on the fate of conazole fungicides in soils and their bioavailability to earthworms and plants by Bošković, Nikola, Bílková, Zuzana, Šudoma, Marek, Bielská, Lucie, Škulcová, Lucia, Ribitsch, Doris, Soja, Gerhard, Vrana, Branislav, Hofman, Jakub

“…  The study showed novel findings about changes in the fate and bioavailability of conazole fungicides (CFs) after biochar (BC) addition to soil. Two…”
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Bruton’s Tyrosine Kinase Inhibitor Zanubrutinib Effectively Modulates Cancer Resistance by Inhibiting Anthracycline Metabolism and Efflux by Čermáková, Lucie, Hofman, Jakub, Laštovičková, Lenka, Havlíčková, Lucie, Špringrová, Ivona, Novotná, Eva, Wsól, Vladimír

“…Zanubrutinib (ZAN) is a Bruton’s tyrosine kinase inhibitor recently approved for the treatment of some non-Hodgkin lymphomas. In clinical trials, ZAN is often…”
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Encorafenib Acts as a Dual-Activity Chemosensitizer through Its Inhibitory Effect on ABCC1 Transporter In Vitro and Ex Vivo by Zhang, Yu, Vagiannis, Dimitrios, Budagaga, Youssif, Sabet, Ziba, Hanke, Ivo, Rozkoš, Tomáš, Hofman, Jakub

“…Encorafenib (LGX818, trade name Braftovi), a novel BRAF inhibitor, has been approved for the treatment of melanoma and colorectal cancer. In the present work,…”
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Inhibition of human anthracycline reductases by emodin — A possible remedy for anthracycline resistance by Hintzpeter, Jan, Seliger, Jan Moritz, Hofman, Jakub, Martin, Hans-Joerg, Wsol, Vladimir, Maser, Edmund

“…The clinical application of anthracyclines, like daunorubicin and doxorubicin, is limited by two factors: dose-related cardiotoxicity and drug resistance. Both…”
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Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment by Zemanova, Lucie, Hofman, Jakub, Novotna, Eva, Musilek, Kamil, Lundova, Tereza, Havrankova, Jana, Hostalkova, Anna, Chlebek, Jakub, Cahlikova, Lucie, Wsol, Vladimír

“…AKR1B10 is an NADPH-dependent reductase that plays an important function in several physiological reactions such as the conversion of retinal to retinol,…”
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In Vitro Transfection Mediated by Dendrigraft Poly(L-lysines): The Effect of Structure and Molecule Size by Hofman, Jakub, Buncek, Martin, Haluza, Radovan, Streinz, Ludvik, Ledvina, Miroslav, Cigler, Petr

“…Dendritic poly(L‐lysines) (DGL) constitute promising nanomaterials applicable as a nonviral gene‐delivery vector. In this study, we evaluate the transfection…”
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Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat by Ahmadimoghaddam, Davoud, Hofman, Jakub, Zemankova, Lenka, Nachtigal, Petr, Dolezelova, Eva, Cerveny, Lukas, Ceckova, Martina, Micuda, Stanislav, Staud, Frantisek

“…The aim of the present study was to investigate the expression, localization, and function of organic cation transporter 3 (Oct3, Slc22a3) and multidrug and…”
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A worldwide review of currently used pesticides' monitoring in agricultural soils by Sabzevari, Shiva, Hofman, Jakub

“…The adverse effects of pesticides on the agricultural ecosystem have been matter of concern in recent decades. However, attention has mostly been directed to…”
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