Search Results - "Hofler, H"

Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology and the College of American Pathologists by DIETEL, M, ELLIS, I. O, HOFLER, H, KREIPE, H, MOCH, H, DANKOF, A, KOLBLE, K, KRISTIANSEN, G

“…HER2 is an important tumour marker in breast cancer. However, there is controversy regarding which method reliably measures HER2 status. This study evaluates…”
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Quantitative Gene Expression Analysis in Microdissected Archival Formalin-Fixed and Paraffin-Embedded Tumor Tissue by Specht, Katja, Richter, Thomas, Müller, Ulrike, Walch, Axel, Werner, Martin, Höfler, Heinz

“…Formalin-fixed, paraffin-embedded tissue is the most widely available material for retrospective clinical studies. In combination with the potential of…”
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Histopathological response after preoperative radiochemotherapy in rectal carcinoma is associated with improved overall survival by Rosenberg, R., Nekarda, H., Zimmermann, F., Becker, K., Lordick, F., Hofler, H., Molls, M., Siewert, J.R.

“…Background Recent studies showed improved local control after preoperative radiochemotherapy (RCTX) in patients with locally advanced rectal carcinoma, but…”
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Mutations of the human E-cadherin (CDH1) gene by Berx, Geert, Becker, Karl-Friedrich, Höfler, Heinz, van Roy, Frans

“…The cell–cell adhesion molecule E‐cadherin is well known to act as a strong invasion suppressor in experimental tumor cell systems. Frequent inactivating…”
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Diffuse Type Gastric and Lobular Breast Carcinoma in a Familial Gastric Cancer Patient with an E-Cadherin Germline Mutation by Keller, Gisela, Vogelsang, Holger, Becker, Ingrid, Hutter, Jörg, Ott, Katja, Candidus, Sonja, Grundei, Tobias, Becker, Karl-Friedrich, Mueller, James, Siewert, Jörg R., Höfler, Heinz

“…E-Cadherin alterations have been reported frequently in sporadic diffuse type gastric and lobular breast carcinomas. Germline mutations of this gene have been…”
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The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models by Fuchs, H, Gailus-Durner, V, Adler, T, Pimentel, J A Aguilar, Becker, L, Bolle, I, Brielmeier, M, Calzada-Wack, J, Dalke, C, Ehrhardt, N, Fasnacht, N, Ferwagner, B, Frischmann, U, Hans, W, Hölter, S M, Hölzlwimmer, G, Horsch, M, Javaheri, A, Kallnik, M, Kling, E, Lengger, C, Maier, H, Mossbrugger, I, Mörth, C, Naton, B, Nöth, U, Pasche, B, Prehn, C, Przemeck, G, Puk, O, Racz, I, Rathkolb, B, Rozman, J, Schäble, K, Schreiner, R, Schrewe, A, Sina, C, Steinkamp, R, Thiele, F, Willershäuser, M, Zeh, R, Adamski, J, Busch, D H, Beckers, J, Behrendt, H, Daniel, H, Esposito, I, Favor, J, Graw, J, Heldmaier, G, Höfler, H, Ivandic, B, Katus, H, Klingenspor, M, Klopstock, T, Lengeling, A, Mempel, M, Müller, W, Neschen, S, Ollert, M, Quintanilla-Martinez, L, Rosenstiel, P, Schmidt, J, Schreiber, S, Schughart, K, Schulz, H, Wolf, E, Wurst, W, Zimmer, A, Hrabé de Angelis, M

“…The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in a standardized and comprehensive way. The result is…”
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Gastric adenocarcinoma : pathomorphology and molecular pathology by WERNER, Martin, HÖFLER, Heinz, BECKER, Karl Friedrich, KELLER, Gisela

“…Two types of gastric adenocarcinoma can be distinguished histopathologically: the diffuse and the intestinal type. Molecular pathology supports this theory by…”
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E-cadherin gene mutations provide clues to diffuse type gastric carcinomas by BECKER, K.-F, ATKINSON, M. J, REICH, U, BECKER, I, NEKARDA, H, SIEWERT, J. R, HÖFLER, H

“…The calcium-dependent homophilic cell adhesion molecule and candidate suppressor gene, E (epithelial)-cadherin, plays a major role in the organization and…”
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Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility by HANDSCHUH, G, CANDIDUS, S, BECKER, K.-F, LUBER, B, REICH, U, SCHOTT, C, OSWALD, S, BECKE, H, HUTZLER, P, BIRCHMEIER, W, HÖFLER, H

“…A major function of the cell-to-cell adhesion molecule E-cadherin is the maintenance of cell adhesion and tissue integrity. E-cadherin deficiency in tumours…”
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Prognostic Impact of Proteolytic Factors (Urokinase-Type Plasminogen Activator, Plasminogen Activator Inhibitor 1, and Cathepsins B, D, and L) in Primary Breast Cancer Reflects Effects of Adjuvant Systemic Therapy by HARBECK, Nadia, ALT, Uta, BERGER, Ursula, KRÜGER, Achim, THOMSSEN, Christoph, JÄNICKE, Fritz, HÖFLER, Heinz, KATES, Ronald E, SCHMITT, Manfred

“…Purpose : Prognostic and predictive impact of five proteolytic factors associated with tumor invasion and metastasis in primary breast cancer were evaluated…”
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HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing by Rüschoff, Josef, Dietel, Manfred, Baretton, Gustavo, Arbogast, Susanne, Walch, Axel, Monges, Geneviéve, Chenard, Marie-Pierre, Penault-Llorca, Frédérique, Nagelmeier, Iris, Schlake, Werner, Höfler, H., Kreipe, H. H.

“…Trastuzumab-based therapy has been shown to confer overall survival benefit in HER2-positive patients with advanced gastric cancer in a large multicentric…”
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Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer by Alves, F, Vogel, W, Mossie, K, Millauer, B, Höfler, H, Ullrich, A

“…Mammary carcinoma kinase 10 (MCK-10) and colon carcinoma kinase 2 (CCK-2) constitute a subclass of receptor tyrosine kinases characterized by a discoidin I…”
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Endoscopic ultrasound criteria for vascular invasion in the staging of cancer of the head of the pancreas: A blind reevaluation of videotapes by Rösch, Thomas, Dittler, Hans-Joachim, Strobel, Klaus, Meining, Alexander, Schusdziarra, Volker, Lorenz, Reinhard, Allescher, Hans-Dieter, Kassem, Abdel Meguid, Gerhardt, Paul, Siewert, Jörg-Rüdiger, Höfler, Heinz, Classen, Meinhard

“…Background: It has been claimed in several prospective studies that endoscopic ultrasonography (EUS) is highly accurate in the locoregional staging of…”
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Chromosomal Imbalances in Barrett's Adenocarcinoma and the Metaplasia-Dysplasia-Carcinoma Sequence by Walch, Axel K., Zitzelsberger, Horst F., Bruch, Jochen, Keller, Gisela, Angermeier, Daniela, Aubele, Michaela M., Mueller, James, Stein, Hubert, Braselmann, Herbert, Siewert, Jörg R., Höfler, Heinz, Werner, Martin

“…To characterize cytogenetic alterations found in Barrett's adenocarcinoma (BA) and, more importantly, its premalignant stages, we studied chromosomal…”
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Denaturing High Pressure Liquid Chromatography (DHPLC) for the Analysis of Somatic p53 Mutations by Keller, Gisela, Hartmann, Arndt, Mueller, James, Höfler, Heinz

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Extensive ductal carcinoma in situ with small foci of invasive ductal carcinoma : Evidence of genetic resemblance by CGH by AUBELE, M, MATTIS, A, ZITZELSBERGER, H, WALCH, A, KREMER, M, WELZL, G, HÖFLER, H, WERNER, M

“…Although ductal carcinoma in situ (DCIS) of the breast is accepted as a potential precursor lesion for invasive ductal cancer (IDC), the critical genetic…”
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Loss of heterozygosity in 11q13-14 regions in gastric neuroendocrine tumors not associated with multiple endocrine neoplasia type 1 syndrome by D'Adda, T, Keller, G, Bordi, C, Höfler, H

“…Loss of heterozygosity (LOH) at the MEN1 gene locus at 11q13 is commonly found in type II gastric carcinoid tumors, which are associated with multiple…”
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Activation of the PI3K/AKT pathway correlates with prognosis in stage II colon cancer by Malinowsky, K, Nitsche, U, Janssen, K-P, Bader, F G, Späth, C, Drecoll, E, Keller, G, Höfler, H, Slotta-Huspenina, J, Becker, K-F

“…Background: Patients with UICC/AJCC stage II colon cancer have a high 5-year overall survival rate after surgery. Nevertheless, a significant subgroup of…”
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MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion by Falkenberg, N, Anastasov, N, Rappl, K, Braselmann, H, Auer, G, Walch, A, Huber, M, Höfig, I, Schmitt, M, Höfler, H, Atkinson, M J, Aubele, M

“…Background: MiR-221/-222 are frequently overexpressed in breast cancer and are associated with increased malignancy. The specific modification of microRNAs…”
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Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer by Jänicke, F, Schmitt, M, Pache, L, Ulm, K, Harbeck, N, Höfler, H, Graeff, H

“…Evidence has accumulated that invasion and metastasis in solid tumors require the action of tumor-associated proteases, which promote the dissolution of the…”
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