Search Results - "Hofland, Johannes"

Advances in the diagnosis and management of well-differentiated neuroendocrine neoplasms by Hofland, Johannes, Kaltsas, Gregory, de Herder, Wouter W

“…ABSTRACTNeuroendocrine neoplasms (NENs) constitute a diverse group of tumors that derive from the sensory and secretory neuroendocrine cells and predominantly…”
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Theranostics in neuroendocrine tumors: an overview of current approaches and future challenges by Refardt, Julie, Hofland, Johannes, Kwadwo, Antwi, Nicolas, Guillaume P., Rottenburger, Christof, Fani, Melpomeni, Wild, Damian, Christ, Emanuel

“…Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors, mainly localized in the gastrointestinal system. What characterizes NENs is the…”
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Management of carcinoid syndrome: a systematic review and meta-analysis by Hofland, Johannes, Herrera-Martínez, Aura D, Zandee, Wouter T, de Herder, Wouter W

“…Carcinoid syndrome (CS) is a debilitating disease caused by functional neuroendocrine tumors. Several treatment options are available to alleviate the hormonal…”
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New Directions in Imaging Neuroendocrine Neoplasms by Refardt, Julie, Hofland, Johannes, Wild, Damian, Christ, Emanuel

“…Purpose of Review Accurate imaging is crucial for correct diagnosis, staging, and therapy of neuroendocrine neoplasms (NENs). The search for the optimal…”
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The role of 11-oxygenated androgens in prostate cancer by Snaterse, Gido, Hofland, Johannes, Lapauw, Bruno

“…11-oxygenated androgens are a class of steroids capable of activating the androgen receptor (AR) at physiologically relevant concentrations. In view of the AR…”
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Should everolimus be stopped after radiological progression in metastatic insulinoma? A “pro” point of view by Zandee, Wouter T., Hofland, Johannes, de Herder, Wouter W.

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Evidence of Limited Contributions for Intratumoral Steroidogenesis in Prostate Cancer by HOFLAND, Johannes, VAN WEERDEN, Wytske M, DITS, Natasja F. J, STEENBERGEN, Jacobie, VAN LEENDERS, Geert J. L. H, JENSTER, Guido, SCHRÖDER, Fritz H, DE JONG, Frank H

“…Androgen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen production might contribute to…”
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Inflammatory markers and long term hematotoxicity of holmium-166-radioembolization in liver-dominant metastatic neuroendocrine tumors after initial peptide receptor radionuclide therapy by Ebbers, Sander C., Brabander, Tessa, Tesselaar, Margot E. T., Hofland, Johannes, Braat, Manon N. G. J. A., Wessels, Frank J., Barentsz, Maarten W., Lam, Marnix G. E. H., Braat, Arthur J. A. T.

“…Purpose In patients with neuroendocrine tumor liver metastases, additional tumor reduction can be achieved by sequential treatment with [ 166…”
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Symptomatic and Radiological Response to 177Lu-DOTATATE for the Treatment of Functioning Pancreatic Neuroendocrine Tumors by Zandee, Wouter T, Brabander, Tessa, Blažević, Anela, Kam, Boen L R, Teunissen, Jaap J M, Feelders, Richard A, Hofland, Johannes, de Herder, Wouter W

“…Abstract Purpose Peptide receptor radionuclide therapy (PRRT) with the radiolabeled somatostatin analogue [Lutetium-177-DOTA0-Tyr3]octreotate (177Lu-DOTATATE)…”
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Epigenetic regulation of SST2 expression in small intestinal neuroendocrine tumors by Klomp, Maria J., Refardt, Julie, van Koetsveld, Peter M., Campana, Claudia, Dalm, Simone U., Dogan, Fadime, van Velthuysen, Marie-Louise F., Feelders, Richard A., de Herder, Wouter W., Hofland, Johannes, Hofland, Leo J.

“…Background Somatostatin receptor type 2 (SST 2 ) expression is critical for the diagnosis and treatment of neuroendocrine tumors and is associated with…”
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Effect of epigenetic treatment on SST2 expression in neuroendocrine tumour patients by Refardt, Julie, Klomp, Maria J., Koetsveld, Peter M., Dogan, Fadime, Konijnenberg, Mark, Brabander, Tessa, Feelders, Richard A., Herder, Wouter W., Hofland, Leo J., Hofland, Johannes

“…In a prospective clinical proof-of-concept trial involving nine advanced NET patients with low SST expression, we were able to show that epigenetic treatment…”
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Intratumoral conversion of adrenal androgen precursors drives androgen receptor-activated cell growth in prostate cancer more potently than de novo steroidogenesis by Kumagai, Jinpei, Hofland, Johannes, Erkens-Schulze, Sigrun, Dits, Natasja F.J., Steenbergen, Jacobie, Jenster, Guido, Homma, Yukio, de Jong, Frank H., van Weerden, Wytske M.

“…BACKGROUND Despite an initial response to hormonal therapy, patients with advanced prostate cancer (PC) almost always progress to castration‐resistant disease…”
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11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration by Snaterse, Gido, van Dessel, Lisanne F, van Riet, Job, Taylor, Angela E, van der Vlugt-Daane, Michelle, Hamberg, Paul, de Wit, Ronald, Visser, Jenny A, Arlt, Wiebke, Lolkema, Martijn P, Hofland, Johannes

“…BACKGROUNDContinued androgen receptor (AR) signaling constitutes a key target for treatment in metastatic castration-resistant prostate cancer (CRPC). Studies…”
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Treatment with somatostatin analogues and PRRT in metastatic middle ear adenoma with neuroendocrine features by Lima Ferreira, Joana, Marques, Bernardo, Menke-van der Houven van Oordt, C Willemien, de Herder, Wouter W, Brabander, Tessa, Hofland, Johannes

“…Summary Middle ear adenomas with neuroendocrine features (ANEF) are rare, with an estimated 150 reported cases. They usually pursue an indolent clinical…”
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Comparison of [18F]DOPA and [68Ga]DOTA-TOC as a PET imaging tracer before peptide receptor radionuclide therapy by Veenstra, Emile B., Brouwers, Adrienne H., de Groot, Derk Jan A., Hofland, Johannes, Walenkamp, Annemiek M. E., Brabander, Tessa, Zandee, Wouter T., Noordzij, Walter

“…Background In treatment of neuroendocrine neoplasms (NENs), confirmation of somatostatin receptor expression with 68 Ga-DOTA somatostatin analogues is…”
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Aberrant tryptophan metabolism in stromal cells is associated with mesenteric fibrosis in small intestinal neuroendocrine tumors by Blažević, Anela, Iyer, Anand M, van Velthuysen, Marie-Louise F, Hofland, Johannes, van Koestveld, Peter M, Franssen, Gaston J H, Feelders, Richard A, Zajec, Marina, Luider, Theo M, de Herder, Wouter W, Hofland, Leo J

“…Background Increased levels of serotonin secretion are associated with mesenteric fibrosis (MF) in small intestinal neuroendocrine tumors (SI-NETs). However,…”
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Inhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation by Hofland, Johannes, Steenbergen, Jacobie, Voorsluijs, Jacoba M, Verbiest, Michael M P J, de Krijger, Ronald R, Hofland, Leo J, de Herder, Wouter W, Uitterlinden, Andre G, Feelders, Richard A, de Jong, Frank H

“…Adrenocortical carcinoma (ACC) is a rare, but highly malignant tumor of unknown origin. Inhibin α-subunit (Inha) knockout mice develop ACCs following…”
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Protein kinase C-induced activin A switches adrenocortical steroidogenesis to aldosterone by suppressing CYP17A1 expression by Hofland, Johannes, Steenbergen, Jacobie, Hofland, Leo J, van Koetsveld, Peter M, Eijken, Marco, van Nederveen, Francien H, Kazemier, Geert, de Herder, Wouter W, Feelders, Richard A, de Jong, Frank H

“…Functional zonation of the adrenal cortex is a consequence of the zone-specific expression of P450c17 (CYP17A1) and its cofactors. Activin and inhibin peptides…”
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The next generation of peptide receptor radionuclide therapy by Brabander, Tessa, Nonnekens, Julie, Hofland, Johannes

“…Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-[Tyr3]octreotate has been successfully developed in the last decades for the treatment of…”
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Molecular Imaging of Neuroendocrine Neoplasms by Refardt, Julie, Hofland, Johannes, Wild, Damian, Christ, Emanuel

“…The key for molecular imaging is the use of a radiotracer with a radioactive and a functional component. While the functional component targets a specific…”
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