Search Results - "Hofhaus, G"

A liposomal formulation for the oral application of the investigational hepatitis B drug Myrcludex B by Uhl, P., Helm, F., Hofhaus, G., Brings, S., Kaufman, C., Leotta, Karin, Urban, S., Haberkorn, U., Mier, W., Fricker, G.

“…[Display omitted] The aim of this study was the development of a liposomal formulation containing specific tetraether lipids for the oral administration of the…”
Get full text

cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities by Bleicken, S, Hofhaus, G, Ugarte-Uribe, B, Schröder, R, García-Sáez, A J

“…The proteins of the Bcl-2 family have a crucial role in mitochondrial outer membrane permeabilization during apoptosis and in the regulation of mitochondrial…”
Get full text

Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin by Bourges, Ingrid, Ramus, Claire, Mousson de Camaret, Bénédicte, Beugnot, Réjane, Remacle, Claire, Cardol, Pierre, Hofhaus, Götz, Issartel, Jean-Paul

“…Mitochondria-encoded ND (NADH dehydrogenase) subunits, as components of the hydrophobic part of complex I, are essential for NADH:ubiquinone oxidoreductase…”
Get full text

Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase by Lisowsky, T., Lee, J.-E., Polimeno, L., Francavilla, A., Hofhaus, G.

“…Background. Augmenter of Liver Regeneration is an important secondary hepatic growth factor. Augmenter of liver regeneration protein has been shown to control…”
Get full text

Efficient selection and characterization of mutants of a human cell line which are defective in mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase by Hofhaus, Götz, Attardi, Giuseppe

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Ineffective hematopoiesis linked with a mitochondrial tRNA mutation (G3242A) in a patient with myelodysplastic syndrome by Gattermann, Norbert, Wulfert, Michael, Junge, Bärbel, Germing, Ulrich, Haas, Rainer, Hofhaus, Götz

“…In a patient with refractory anemia with excess blasts (RAEB), a somatic mutation of mitochondrial transfer RNALeu(UUR) was detected in bone marrow cells…”
Get full text

Severe Impairment of Nucleotide Synthesis Through Inhibition of Mitochondrial Respiration by Gattermann, N., Dadak, M., Hofhaus, G., Wulfert, M., Berneburg, M., Loeffler, M. L., Simmonds, H. A.

“…Since de-novo synthesis of pyrimidine nucleotides is coupled to the mitochondrial respiratory chain (RC) via dehydroorotic acid dehydrogenase (DHODH),…”
Get full text

Role of mitochondria in Parkinson disease by Kösel, S, Hofhaus, G, Maassen, A, Vieregge, P, Graeber, M B

“…The cause of the selective degeneration of nigrostriatal neurons in Parkinson disease (PD) has remained largely unknown. Exceptions include rare missense…”
Get more information

Lack of assembly of mitochondrial DNA‐encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in a human cell mutant lacking the mitochondrial ND4 gene product by Hofhaus, G., Attardi, G.

“…In most eukaryotic cells, the respiratory chain NADH dehydrogenase (Complex I) is a multimeric enzyme under dual (nuclear and mitochondrial) genetic control…”
Get full text

Live now - pay by ageing: high performance mitochondrial activity in youth and its age-related side effects by Hofhaus, G., Berneburg, M., Wulfert, M., Gattermann, N.

“…Radical oxygen species are a byproduct of normal energy metabolism in mitochondria. The short-lived radicals cause damage to their immediate surrounding, i.e…”
Get full text

How frequent is mutation in the mitochondrial cytochrome c oxidase gene in patients with myelodysplastic syndromes? by Gattermann, N., Wulfert, M., Hofhaus, G.

Get full text

Mitochondria harbouring mutant mtDNA--a cuckoo in the nest? by Hofhaus, G, Gattermann, N

“…Mutations of the mitochondrial DNA (mtDNA) are associated with a number of human diseases. To become relevant in terms of pathology, a mutation must generally…”
Get more information

Yeast Erv2p Is the First Microsomal FAD-linked Sulfhydryl Oxidase of the Erv1p/Alrp Protein Family by Gerber, Jana, Mühlenhoff, Ulrich, Hofhaus, Götz, Lill, Roland, Lisowsky, Thomas

“…Saccharomyces cerevisiae Erv2p was identified previously as a distant homologue of Erv1p, an essential mitochondrial protein exhibiting sulfhydryl oxidase…”
Get full text

Comprehensive, rapid and sensitive detection of sequence variants of human mitochondrial tRNA genes by Michikawa, Yuichi, Hofhaus, Götz, Lerman, Leonard S., Attardi, Giuseppe

“…In the present study, a comprehensive, rapid and sensitive method for screening sequence variation of the human mitochondrial tRNA genes has been developed…”
Get full text

Defects of mitochondrial respiratory chain in multiple symmetric lipomatosis by BECKER-WEGERICH, P, STEUBER, M, OLBRISCH, R, RUZICKA, T, AUBURGER, G, HOFHAUS, G

“…Using lymphocytes from nine unrelated patients with multiple symmetric lipomatosis we investigated a possible defect in the mitochondrial respiratory chain as…”
Get full text

Respiration and Growth Defects in Transmitochondrial Cell Lines Carrying the 11778 Mutation Associated with Leber's Hereditary Optic Neuropathy by Hofhaus, G, Johns, D R, Hurko, O, Attardi, G, Chomyn, A

“…Mitochondrial DNA from two genetically unrelated patients carrying the mutation at position 11778 that causes Leber's hereditary optic neuropathy has been…”
Get full text

Antisense RNA crossing mitochondrial membrane? by Hofhaus, G, Gattermann, N, Enríquez, J A

Get full text

Identification and electron microscopic analysis of a chaperonin oligomer from Neurospora crassa mitochondria by Hutchinson, E. G., Tichelaar, W., Hofhaus, G., Weiss, H., Leonard, K. R.

“…A 7‐fold symmetric particle has been identified in Neurospora crassa which is most probably the mitochondrial chaperonin. The particle, about 12 nm in…”
Get full text

Erv1p from Saccharomyces cerevisiae is a FAD-linked sulfhydryl oxidase by Lee, Jeung-Eun, Hofhaus, Götz, Lisowsky, Thomas

“…The yeast ERV1 gene encodes a small polypeptide of 189 amino acids that is essential for mitochondrial function and for the viability of the cell. In this…”
Get full text

Heteroplasmic Point Mutations of Mitochondrial DNA Affecting Subunit I of Cytochrome c Oxidase in Two Patients With Acquired Idiopathic Sideroblastic Anemia by Gattermann, Norbert, Retzlaff, Stefan, Wang, Yan-Ling, Hofhaus, Götz, Heinisch, Jürgen, Aul, Carlo, Schneider, Wolfgang

“…Mitochondrial iron overload in acquired idiopathic sideroblastic anemia (AISA) may be attributable to mutations of mitochondrial DNA (mtDNA), because these can…”
Get full text