Search Results - "Hoffstein, S T"

Cartilage proteoglycans inhibit fibronectin-mediated adhesion by Rich, A. M, Pearlstein, E, Weissmann, G, Hoffstein, S. T

“…The authors set out to determine whether a component of cartilage could prevent fibroblast adherence in a defined adhesion assay. As normal cartilage is…”
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Stimulus-Specific Induction of Phospholipid and Arachidonic Acid Metabolism in Human Neutrophils by Godfrey, Richard W., Manzi, Rosalie M., Clark, Mike A., Hoffstein, Sylvia T.

“…Phospholipid remodeling resulting in arachidonic acid (AA) release and metabolism in human neutrophils stimulated by calcium ionophore A23187 has been…”
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Ultrastructural Demonstration of Calcium Loss from Local Regions of the Plasma Membrane of Surface-Stimulated Human Granulocytes by Hoffstein, Sylvia T

“…Abstract Most cell-associated calcium exists as bound rather than free ionized calcium. Since calcium and other cations are important regulators of…”
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Anion Channel Blockers Inhibit Lysosomal Enzyme Secretion from Human Neutrophils without Affecting Generation of Superoxide Anion by Korchak, H. M., Eisenstat, B. A., Hoffstein, S. T., Dunham, P. B., Weissmann, Gerald

“…The role of permeant anions in lysosomal enzyme secretion from human neutrophils was investigated by means of anion-channel-blocking agents:…”
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Leukotriene D4 (LTD4) induces mucus secretion from goblet cells in the guinea pig respiratory epithelium by Hoffstein, S T, Malo, P E, Bugelski, P, Wheeldon, E B

“…To study the potential role of leukotriene (LTD4) as a mucus secretagogue, anesthetized and spontaneously breathing guinea pigs were intubated and challenged…”
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Cytochemical demonstration of constitutive H2O2 production by macrophages in synovial tissue from rats with adjuvant arthritis by Hoffstein, ST, Gennaro, DE, Meunier, PC

“…Generation of toxic oxygen metabolites by inflammatory cells is considered to be one of the mechanisms by which inflammation produces tissue injury. This…”
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Quantitative immunocytochemical staining for recombinant tissue-type plasminogen activator in transfected Chinese hamster ovary cells by Gennaro, D E, Hoffstein, S T, Marks, G, Ramos, L, Oka, M S, Reff, M E, Hart, T K, Bugelski, P J

“…Tissue-type plasminogen activator (tPA) is a serine protease which cleaves plasminogen to its active form, plasmin. tPA plays a physiologic role in hemostasis,…”
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A new cytochemical method for ultrastructural detection of liposomes in tissues in vivo by Bugelski, PJ, Gennaro, DE, Poste, G, Hoffstein, ST

“…Multilamellar vesicles (MLVs) have been used as drug carriers to increase efficacy or decrease toxicity of a variety of therapeutic agents, including…”
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Internalization of recombinant tissue-type plasminogen activator by isolated rat hepatocytes is via coated pits by Marks, G J, Hart, T K, Rush, G F, Hoffstein, S T, Fong, K L, Bugelski, P J

“…The uptake and internalization of tissue-type plasminogen activator (t-PA) by freshly isolated rat hepatocytes was investigated. Electron microscopic…”
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Surface contact inhibits neutrophil superoxide generation induced by soluble stimuli by Hoffstein, S T, Gennaro, D E, Manzi, R M

“…Human neutrophils in suspension undergo a metabolic burst and generate reactive O2- metabolites upon exposure to many soluble and particulate stimuli. They can…”
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Neutrophils may directly synthesize both H2O2 and O2- since surface stimuli induce their release in stimulus-specific ratios by HOFFSTEIN, S. T, GENNARO, D. E, MANZI, R. M

“…Many stimuli induce neutrophils to undergo an oxidative burst and generate toxic oxygen metabolites. The major products are O2- and H2O2, the latter being…”
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Phospholipid and arachidonic acid metabolism in zymosan-stimulated human monocytes: modulation by cAMP by Godfrey, R W, Manzi, R M, Gennaro, D E, Hoffstein, S T

“…Receptor-ligand interaction in mononuclear phagocytes is intimately linked to alterations in membrane phospholipids and release of arachidonic acid (AA). In…”
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Thyrotropin-releasing hormone stimulation of prolactin release from clonal rat pituitary cells: evidence for action independent of extracellular calcium by Gershengorn, M C, Hoffstein, S T, Rebecchi, M J, Geras, E, Rubin, B G

“…Thyrotropin-releasing hormone (TRH) stimulates prolactin release and (45)Ca(2+) efflux from GH(3) cells, a clonal strain of rat pituitary cells. Elevation of…”
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Interleukin-1 and tumor necrosis factor are not synergistic for human synovial fibroblast PLA2 activation and PGE2 production by Godfrey, R W, Johnson, W J, Newman, T, Hoffstein, S T

“…Patterns of arachidonic acid release and metabolism were altered in human synovial fibroblasts following exposure to cytokines. Recombinant interleukin-1…”
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Inverse correlation between neutrophil microtubule numbers and enhanced random migration by Rich, A M, Hoffstein, S T

“…The random migration of neutrophils under agarose as measured by the number of cells leaving the well, is enhanced when the pH or the osmolality of the medium…”
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Fibonectin is a component of the surface coat of human neutrophils by Hoffstein, S T, Weissmann, G, Pearlstein, E

“…Although adherence to surfaces is central to neutrophil function many of the determinants of neutrophil adherence are still unknown. The possible involvement…”
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Influence of Divalent Cations upon Complement-Mediated Enzyme Release from Human Polymorphonuclear Leukocytes by Goldstein, Ira M, Hoffstein, Sylvia T, Weissmann, Gerald

“…The complement component, C5a provokes the selective release of granule-associated enzymes from the intact, viable cytochalasin B-treated human…”
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Recombinant tumor necrosis factor and interleukin-1 both stimulate human synovial cell arachidonic acid release and phospholipid metabolism by Godfrey, R W, Johnson, W J, Hoffstein, S T

“…Stimulation of [3H]-arachidonic acid labeled human synovial cells with 3.0 X 10(-10)M recombinant interleukin-1 or tumor necrosis factor resulted in the…”
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Structural requirements for chemotactic activity of leukotriene B4 (LTB4) by Hoffstein, S T, Manzi, R M, Razgaitis, K A, Bender, P E, Gleason, J

“…LTB4 (5s, 12R dihdroxy-6, 14-CIS-8, 10-trans-eicosatetraenoic acid) formed in activated neutrophils by lipoxygenation of arachidonic acid is an extremely…”
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Interleukin-1 stimulation of phospholipase activity in rat synovial fibroblasts. Possible regulation by cyclooxygenase products by Godfrey, R W, Johnson, W J, Hoffstein, S T

“…Tritiated arachidonic acid (3H-AA)-labeled rat synovial fibroblasts stimulated with human recombinant interleukin-1 beta (rIL-1 beta) released incorporated…”
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