Search Results - "Hoffmann, W E"

Rhythmic theta and delta activity of cortical and hippocampal neuronal networks in genetically or pharmacologically induced N -methyl- d -aspartate receptor hypofunction under urethane anesthesia by Kiss, T, Feng, J, Hoffmann, W.E, Shaffer, C.L, Hajós, M

“…Highlights ► Pharmacologically and genetically induced NMDAR hypofunction was assessed in rats and mice. ► MK-801 reduced both spontaneous and elicited…”
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Modulation of hippocampal theta oscillation by histamine H3 receptors by Hajós, M, Siok, C J, Hoffmann, W E, Li, S, Kocsis, B

“…Preclinical findings demonstrate procognitive actions of histamine 3 (H3) receptor antagonists/inverse agonists. Since a prominent role of neuronal network…”
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Liver Histopathology and Liver and Serum Alanine Aminotransferase and Alkaline Phosphatase Activities in Epileptic Dogs Receiving Phenobarbital by Gaskill, C. L, Miller, L. M, Mattoon, J. S, Hoffmann, W. E, Burton, S. A, Gelens, H. C. J, Ihle, S. L, Miller, J. B, Shaw, D. H, Cribb, A. E

“…Phenobarbital (PB) therapy is frequently associated with elevated serum alanine aminotransferase (ALT) and alkaline phosphatase (AP) activities in dogs without…”
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Modulation of septo-hippocampal θ activity by GABAA receptors: An experimental and computational approach by HAJOS, M, HOFFMANN, W. E, ORBAN, G, KISS, T, ERDI, P

“…Theta frequency oscillation of the septo-hippocampal system has been considered as a prominent activity associated with cognitive function and affective…”
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Reduction of brain kynurenic acid improves cognitive function by Kozak, Rouba, Campbell, Brian M, Strick, Christine A, Horner, Weldon, Hoffmann, William E, Kiss, Tamas, Chapin, Douglas S, McGinnis, Dina, Abbott, Amanda L, Roberts, Brooke M, Fonseca, Kari, Guanowsky, Victor, Young, Damon A, Seymour, Patricia A, Dounay, Amy, Hajos, Mihaly, Williams, Graham V, Castner, Stacy A

“…The elevation of kynurenic acid (KYNA) observed in schizophrenic patients may contribute to core symptoms arising from glutamate hypofunction, including…”
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A Novel Positive Allosteric Modulator of the alpha 7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization by Hurst, Raymond S, Hajos, Mihaly, Raggenbass, Mario, Wall, Theron M, Higdon, Nicole R, Lawson, Judy A, Rutherford-Root, Karen L, Berkenpas, Mitchell B, Hoffmann, W E, Piotrowski, David W, Groppi, Vincent E, Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P

“…Several lines of evidence suggest a link between the alpha 7 neuronal nicotinic acetylcholine receptor (nAChR) and brain disorders including schizophrenia,…”
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Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT1A receptors by HAJOS, M, HOFFMANN, W. E, TETKO, I. V, HYLAND, B, SHARP, T, VILLA, A. E. P

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Association between Absolute Tumor Burden and Serum Bone-Specific Alkaline Phosphatase in Canine Appendicular Osteosarcoma by Sternberg, R.A., Pondenis, H.C., Yang, X., Mitchell, M.A., O'Brien, R.T., Garrett, L.D., Helferich, W.G., Hoffmann, W.E., Fan, T.M.

“…Background In dogs with appendicular osteosarcoma (OSA), increased pretreatment serum bone‐specific alkaline phosphatase (BALP) activity is a negative…”
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Biological variability in serum and urinary indices of bone formation and resorption in dogs by Ladlow, J F, Hoffmann, W E, Breur, G J, Richardson, D C, Allen, M J

“…Serum and urinary assays of bone markers provide a noninvasive alternative to bone biopsy in the study of bone metabolism in humans. Many of the commercial…”
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Discovery and Structure-Activity Relationship of Quinuclidine Benzamides as Agonists of alpha 7 Nicotinic Acetylcholine Receptors by Bodnar, AL, Cortes-Burgos, LA, Cook, K K, Dinh, D M, Groppi, V E, Hajos, M, Higdon, N R, Hoffmann, W E, Hurst, R S, Myers, J K, Rogers, B N, Wall, T M, Wolfe, M L, Wong, E

“…A library of benzamides was tested for alpha 7 nicotinic acetylcholine receptor (nAChR) agonist activity using a chimeric receptor in a functional, cell-based,…”
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A comparison of two techniques for the determination of serum bone-specific alkaline phosphatase activity in dogs by ALLEN, L.C.V., ALLEN, M.J., BREUR, G.J., HOFFMANN, W.E., RICHARDSON, D.C.

“…Bone-specific alkaline phosphatase (BALP) shows potential as a marker of bone formation in the dog. Recent studies have indicated that serum BALP may provide a…”
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Automated and semiautomated analysis of rat alkaline phosphatase isoenzymes by Hoffmann, W E, Everds, N, Pignatello, M, Solter, P F

“…A semiautomated quantitative assay for rat serum alkaline phosphatase (ALP) isoenzyme determination was developed, incorporating selective precipitation of…”
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Urinary markers of type I collagen degradation in the dog by ALLEN, M.J, ALLEN, L.C.V, HOFFMANN, W.E, RICHARDSON, D.C, BREUR, G.J

“…Urinary assays for type I collagen metabolites provide a non invasive index of bone resorption in humans, and are widely used in the management of patients…”
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Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats by Watkins, B A, Li, Y, Allen, K G, Hoffmann, W E, Seifert, M F

“…The effects of dietary polyunsaturated fatty acids (PUFA) on ex vivo bone prostaglandin E(2) (PGE(2)) production and bone formation rate were evaluated in…”
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MICROCYSTIN-LR DECREASES HEPATIC AND RENAL PERFUSION, AND CAUSES CIRCULATORY SHOCK, SEVERE HYPOGLYCEMIA, AND TERMINAL HYPERKALEMIA IN INTRAVASCULARLY DOSED SWINE by Beasley, V R, Lovell, R A, Holmes, K R, Walcott, H E, Schaeffer, D J, Hoffmann, W E, Carmichael, W W

“…Cross-bred, anesthetized female swine were given intravascularly a lethal (72 µg/kg; n = 6) or toxic-sublethal (25 µg/kg; n = 6) dose of microcystin-LR (MCLR),…”
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Canine corticosteroid-induced alkaline phosphatase in serum was solubilized by phospholipase activity in vivo by Solter, P F, Hoffmann, W E

“…In this study, gas chromatography/mass spectrometry revealed the presence of stoichiometric amounts of myo-inositol in association with serum…”
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Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy by ATCHISON, C. R, BALAKUMARAN, A, WEST, A. B, HOFFMANN, W. E, TREINEN-MOSLEN, M

“…Although clinical reports note aging and gender as risk factors for NSAID therapy associated gastroenteropathy, neither variable has been examined in an animal…”
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Antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-AJ76 and (+)-UH232 by Piercey, M F, Lum, J T, Hoffmann, W E, Carlsson, A, Ljung, E, Svensson, K

“…The aminotetralins (+)-AJ76 and (+)-UH232 are stimulant dopaminergic antagonists, which may preferentially antagonize autoreceptors of dopamine nerve…”
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Inhibition of dopamine neuron firing by pramipexole, a dopamine D3 receptor-preferring agonist : comparison to other dopamine receptor agonists by PIERCEY, M. F, HOFFMANN, W. E, SMITH, M. W, HYSLOP, D. K

“…Pramipexole, an amino-benzathiazole [(S)-4,5,6,7-tetrahydro-N-6-propyl-2, 6-benzothiazolediamine dihydrochloride monohydrate] direct-acting dopamine receptor…”
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CCK-8 infusion increases plasma LMW alkaline phosphatase coincident with enterohepatic circulation of bile acids by Solter, P F, Hoffmann, W E, Chambers, M D, Schaeffer, D J

“…Bile acids may facilitate the release of liver alkaline phosphatase (ALP) from its hydrophobic membrane anchor. The purpose of this study was to determine…”
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