Search Results - "Hoffmann, Peter K"

Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation by Erdemli, Gül, Kim, Albert M, Ju, Haisong, Springer, Clayton, Penland, Robert C, Hoffmann, Peter K

“…The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced…”
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Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity by De Alwis, Donald, Foley, C. Michael, Herman, Eugene, Hill, Adam P., Hoffmann, Peter K., Kanda, Yasunari, Kaushik, Emily, Pierson, Jennifer, Puglisi, Raechel, Shi, Hong, Yang, Xi, Pugsley, Michael K.

“…The Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee designed and created a publicly accessible database with an initial set of 128…”
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Neuroinformatics: the integration of shared databases and tools towards integrative neuroscience by Amari, Shun-Ichi, Beltrame, Francesco, Bjaalie, Jan G, Dalkara, Turgay, De Schutter, Erik, Egan, Gary F, Goddard, Nigel H, Gonzalez, Carmen, Grillner, Sten, Herz, Andreas, Hoffmann, K-Peter, Jaaskelainen, Iiro, Koslow, Stephen H, Lee, Soo-Young, Matthiessen, Line, Miller, Perry L, Da Silva, Fernando Mira, Novak, Mirko, Ravindranath, Viji, Ritz, Raphael, Ruotsalainen, Ulla, Sebestra, Vaclav, Subramaniam, Shankar, Tang, Yiyuan, Toga, Arthur W, Usui, Shiro, Van Pelt, Jaap, Verschure, Paul, Willshaw, David, Wrobel, Andrzej

“…There is significant interest amongst neuroscientists in sharing neuroscience data and analytical tools. The exchange of neuroscience data and tools between…”
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Nonclinical Safety Biomarkers of Drug-induced Vascular Injury: Current Status and Blueprint for the Future by Mikaelian, Igor, Cameron, Mark, Dalmas, Deidre A., Enerson, Bradley E., Gonzalez, Raymond J., Guionaud, Silvia, Hoffmann, Peter K., King, Nicholas M. P., Lawton, Michael P., Scicchitano, Marshall S., Smith, Holly W., Thomas, Roberta A., Weaver, James L., Zabka, Tanja S.

“…Better biomarkers are needed to identify, characterize, and/or monitor drug-induced vascular injury (DIVI) in nonclinical species and patients. The Predictive…”
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An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs by Pugsley, Michael K., Guth, Brian, Chiang, Alan Y., Doyle, Jennifer M., Engwall, Michael, Guillon, Jean-Michel, Hoffmann, Peter K., Koerner, John E., Mittelstadt, Scott W., Pierson, Jennifer Beck, Rossman, Eric I., Sarazan, Dustan R., Parish, Stanley T.

“…The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which…”
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An evaluation of the utility of LVdP/dt 40 , QA interval, LVdP/dt min and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs by Pugsley, Michael K, Guth, Brian, Chiang, Alan Y, Doyle, Jennifer M, Engwall, Michael, Guillon, Jean-Michel, Hoffmann, Peter K, Koerner, John E, Mittelstadt, Scott W, Pierson, Jennifer Beck, Rossman, Eric I, Sarazan, Dustan R, Parish, Stanley T

“…The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which…”
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Neuroscience data and tool sharing: a legal and policy framework for neuroinformatics by Eckersley, Peter, Egan, Gary F, Amari, Shun-ichi, Beltrame, Francesco, Bennett, Rob, Bjaalie, Jan G, Dalkara, Turgay, De Schutter, Erik, Gonzalez, Carmen, Grillner, Sten, Herz, Andreas, Hoffmann, K Peter, Jaaskelainen, Iiro P, Koslow, Stephen H, Lee, Soo-Young, Matthiessen, Line, Miller, Perry L, da Silva, Fernando Mira, Novak, Mirko, Ravindranath, Viji, Ritz, Raphael, Ruotsalainen, Ulla, Subramaniam, Shankar, Toga, Arthur W, Usui, Shiro, van Pelt, Jaap, Verschure, Paul, Willshaw, David, Wrobel, Andrzej, Tang, Yiyuan

“…The requirements for neuroinformatics to make a significant impact on neuroscience are not simply technical--the hardware, software, and protocols for…”
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An Assessment of Drug-Induced Changes in Cardiac Inotropy and Lusitropy Parameters in Dogs: Results from a HESI-sponsored Consortium by Pugsley, Michael K., Guth, Brian D., Chiang, Alan Y., Doyle, Jennifer M., Engwall, Michael, Guillon, Jean-Michel, Hoffmann, Peter K., Koerner, John, Mittelstadt, Scott, Pierson, Jennifer Beck, Rossman, Eric, Parish, Stanley T., Sarazan, R. Dustan

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Health and environmental sciences institute integrated strategies working group: Update on the evaluation of drug-induced changes in the cardiac inotropy in dogs by Engwall, Michael J., Walisser, Jacqueline A., Saul, Jim, Dustan Sarazan, R., Guth, Brian, Market, Michael, Skinner, Matthew, Guillon, Jean-Michel, Ottinger, Sean, Heyen, Jonathan R., Cools, Frank, Hoffmann, Peter K., Rossman, Eric I., Pierson, Jennifer B.

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Cardiac safety implications of hNav1.5 blockade and a framework for preclinical evaluation by Gul eErdemli, Albert M Kim, Haisong eJu, Clayton eSpringer, Robert C Penland, Peter K Hoffmann

“…The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced…”
Get full text