Search Results - "Hoffmann, Per"

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany by Streeck, Hendrik, Schulte, Bianca, Kümmerer, Beate M., Richter, Enrico, Höller, Tobias, Fuhrmann, Christine, Bartok, Eva, Dolscheid-Pommerich, Ramona, Berger, Moritz, Wessendorf, Lukas, Eschbach-Bludau, Monika, Kellings, Angelika, Schwaiger, Astrid, Coenen, Martin, Hoffmann, Per, Stoffel-Wagner, Birgit, Nöthen, Markus M., Eis-Hübinger, Anna M., Exner, Martin, Schmithausen, Ricarda Maria, Schmid, Matthias, Hartmann, Gunther

“…A SARS-CoV2 super-spreading event occurred during carnival in a small town in Germany. Due to the rapidly imposed lockdown and its relatively closed community,…”
Get full text

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants by Tsoi, Lam C., Stuart, Philip E., Tian, Chao, Gudjonsson, Johann E., Das, Sayantan, Zawistowski, Matthew, Ellinghaus, Eva, Barker, Jonathan N., Chandran, Vinod, Dand, Nick, Duffin, Kristina Callis, Enerbäck, Charlotta, Esko, Tõnu, Franke, Andre, Gladman, Dafna D., Hoffmann, Per, Kingo, Külli, Kõks, Sulev, Krueger, Gerald G., Lim, Henry W., Metspalu, Andres, Mrowietz, Ulrich, Mucha, Sören, Rahman, Proton, Reis, Andre, Tejasvi, Trilokraj, Trembath, Richard, Voorhees, John J., Weidinger, Stephan, Weichenthal, Michael, Wen, Xiaoquan, Eriksson, Nicholas, Kang, Hyun M., Hinds, David A., Nair, Rajan P., Abecasis, Gonçalo R., Elder, James T

“…Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for…”
Get full text

Differential DNA methylation and mRNA transcription in gingival tissues in periodontal health and disease by Kim, Hyunjin, Momen‐Heravi, Fatemeh, Chen, Steven, Hoffmann, Per, Kebschull, Moritz, Papapanou, Panos N.

“…Aim We investigated differential DNA methylation in gingival tissues in periodontal health, gingivitis, and periodontitis, and its association with…”
Get full text

A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis by Munz, Matthias, Willenborg, Christina, Richter, Gesa M, Jockel-Schneider, Yvonne, Graetz, Christian, Staufenbiel, Ingmar, Wellmann, Jürgen, Berger, Klaus, Krone, Bastian, Hoffmann, Per, van der Velde, Nathalie, Uitterlinden, André G, de Groot, Lisette C P G M, Sawalha, Amr H, Direskeneli, Haner, Saruhan-Direskeneli, Güher, Guzeldemir-Akcakanat, Esra, Keceli, Gencay, Laudes, Matthias, Noack, Barbara, Teumer, Alexander, Holtfreter, Birte, Kocher, Thomas, Eickholz, Peter, Meyle, Jörg, Doerfer, Christof, Bruckmann, Corinna, Lieb, Wolfgang, Franke, Andre, Schreiber, Stefan, Nohutcu, Rahime M, Erdmann, Jeanette, Loos, Bruno G, Jepsen, Soeren, Dommisch, Henrik, Schaefer, Arne S

“…Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%…”
Get full text

Desaturase Activity and the Risk of Type 2 Diabetes and Coronary Artery Disease: A Mendelian Randomization Study by Jäger, Susanne, Cuadrat, Rafael, Hoffmann, Per, Wittenbecher, Clemens, Schulze, Matthias B

“…Estimated Δ5-desaturase (D5D) and Δ6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with…”
Get full text

Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus by Schulz, Herbert, Ruppert, Ann-Kathrin, Herms, Stefan, Wolf, Christiane, Mirza-Schreiber, Nazanin, Stegle, Oliver, Czamara, Darina, Forstner, Andreas J., Sivalingam, Sugirthan, Schoch, Susanne, Moebus, Susanne, Pütz, Benno, Hillmer, Axel, Fricker, Nadine, Vatter, Hartmut, Müller-Myhsok, Bertram, Nöthen, Markus M., Becker, Albert J., Hoffmann, Per, Sander, Thomas, Cichon, Sven

“…Emerging evidence emphasizes the strong impact of regulatory genomic elements in neurodevelopmental processes and the complex pathways of brain disorders. The…”
Get full text

Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells by Fernandez-Rebollo, Eduardo, Mentrup, Birgit, Ebert, Regina, Franzen, Julia, Abagnale, Giulio, Sieben, Torsten, Ostrowska, Alina, Hoffmann, Per, Roux, Pierre-François, Rath, Björn, Goodhardt, Michele, Lemaitre, Jean-Marc, Bischof, Oliver, Jakob, Franz, Wagner, Wolfgang

“…Culture medium of mesenchymal stromal cells (MSCs) is usually supplemented with either human platelet lysate (HPL) or fetal calf serum (FCS). Many studies have…”
Get full text

Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus by Zhao, Ling, Mühleisen, Thomas W., Pelzer, Dominique I., Burger, Bettina, Beins, Eva C., Forstner, Andreas J., Herms, Stefan, Hoffmann, Per, Amunts, Katrin, Palomero-Gallagher, Nicola, Cichon, Sven

“…•Receptor density and gene expression data are from the same human hippocampal tissue.•Significant differences in receptor density only found in metabotropic…”
Get full text

Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci by Munz, Matthias, Richter, Gesa M, Loos, Bruno G, Jepsen, Søren, Divaris, Kimon, Offenbacher, Steven, Teumer, Alexander, Holtfreter, Birte, Kocher, Thomas, Bruckmann, Corinna, Jockel-Schneider, Yvonne, Graetz, Christian, Ahmad, Ilyas, Staufenbiel, Ingmar, van der Velde, Nathalie, Uitterlinden, André G, de Groot, Lisette C P G M, Wellmann, Jürgen, Berger, Klaus, Krone, Bastian, Hoffmann, Per, Laudes, Matthias, Lieb, Wolfgang, Franke, Andre, Erdmann, Jeanette, Dommisch, Henrik, Schaefer, Arne S

“…Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. It…”
Get full text

Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype by Migliorini, Gabriele, Fiege, Bettina, Hosking, Fay J., Ma, Yussanne, Kumar, Rajiv, Sherborne, Amy L., da Silva Filho, Miguel Inacio, Vijayakrishnan, Jayaram, Koehler, Rolf, Thomsen, Hauke, Irving, Julie A., Allan, James M., Lightfoot, Tracy, Roman, Eve, Kinsey, Sally E., Sheridan, Eamonn, Thompson, Pamela, Hoffmann, Per, Nöthen, Markus M., Mühleisen, Thomas W., Eisele, Lewin, Zimmermann, Martin, Bartram, Claus R., Schrappe, Martin, Greaves, Mel, Stanulla, Martin, Hemminki, Kari, Houlston, Richard S.

“…Acute lymphoblastic leukemia (ALL) is the major pediatric cancer diagnosed in economically developed countries with B-cell precursor (BCP)-ALL, accounting for…”
Get full text

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma by Nettersheim, Daniel, Jostes, Sina, Sharma, Rakesh, Schneider, Simon, Hofmann, Andrea, Ferreira, Humberto J, Hoffmann, Per, Kristiansen, Glen, Esteller, Manel B, Schorle, Hubert

“…Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. Seminomas are similar to carcinoma in situ (CIS) cells, the common…”
Get full text

Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression by Kaut, Oliver, Schmitt, Ina, Hofmann, Andrea, Hoffmann, Per, Schlaepfer, Thomas E., Wüllner, Ullrich, Hurlemann, René

“…Current perspectives on the molecular underpinnings of major depressive disorder (MDD) posit a mechanistic role of epigenetic DNA modifications in mediating…”
Get full text

Genome-Wide Association Study on Differentiated Thyroid Cancer by Köhler, Aleksandra, Chen, Bowang, Gemignani, Federica, Elisei, Rossella, Romei, Cristina, Figlioli, Gisella, Cipollini, Monica, Cristaudo, Alfonso, Bambi, Franco, Hoffmann, Per, Herms, Stefan, Kalemba, Michał, Kula, Dorota, Harris, Shelley, Broderick, Peter, Houlston, Richard, Pastor, Susana, Marcos, Ricard, Velázquez, Antonia, Jarząb, Barbara, Hemminki, Kari, Landi, Stefano, Försti, Asta

“…Context: Genome-wide association studies (GWASs) of differentiated thyroid cancer (DTC) have identified associations with polymorphisms at 2q35 (DIRC3), 8p12…”
Get full text

Association between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification by Pechlivanis, Sonali, Mahabadi, Amir A, Hoffmann, Per, Nöthen, Markus M, Broecker-Preuss, Martina, Erbel, Raimund, Moebus, Susanne, Stang, Andreas, Jöckel, Karl-Heinz

“…To examine the association between lipoprotein(a) (Lp(a)) levels, LPA (rs10455872 and rs3798220) and IL1F9 (rs13415097) single nucleotide polymorphisms (SNPs)…”
Get full text

Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment by Yde Ohki, Cristine Marie, Walter, Natalie Monet, Rickli, Michelle, Iseli, Cedric, Werling, Anna Maria, Döring, Christian, Rubio, Belén, Hoffmann, Per, Herms, Stefan, Walitza, Susanne, Grünblatt, Edna

“…As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a…”
Get full text

Epigenome-Wide Analysis of DNA Methylation in Parkinson's Disease Cortex by Kaut, Oliver, Schmitt, Ina, Stahl, Fabian, Fröhlich, Holger, Hoffmann, Per, Gonzalez, Frank J, Wüllner, Ullrich

“…Background: Epigenetic factors including DNA methylation contribute to specific patterns of gene expression. Gene−environment interactions can change the…”
Get full text

Genetic risk scores for coronary artery disease and its traditional risk factors: Their role in the progression of coronary artery calcification-Results of the Heinz Nixdorf Recall study by Pechlivanis, Sonali, Moebus, Susanne, Lehmann, Nils, Erbel, Raimund, Mahabadi, Amir A, Hoffmann, Per, Jöckel, Karl-Heinz, Nöthen, Markus M, Bachmann, Hagen S

“…Atherosclerosis is the primary cause of coronary artery disease (CAD). Several observational studies have examined the association of traditional CAD risk…”
Get full text

Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing by Corominas, Jordi, Klein, Marieke, Zayats, Tetyana, Rivero, Olga, Ziegler, Georg C., Pauper, Marc, Neveling, Kornelia, Poelmans, Geert, Jansch, Charline, Svirin, Evgeniy, Geissler, Julia, Weber, Heike, Reif, Andreas, Arias Vasquez, Alejandro, Galesloot, Tessel E., Kiemeney, Lambertus A. L. M., Buitelaar, Jan K., Ramos-Quiroga, Josep-Antoni, Cormand, Bru, Ribasés, Marta, Hveem, Kristian, Gabrielsen, Maiken Elvestad, Hoffmann, Per, Cichon, Sven, Haavik, Jan, Johansson, Stefan, Jacob, Christian P., Romanos, Marcel, Franke, Barbara, Lesch, Klaus-Peter

“…Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a complex genetic background, hampering identification of…”
Get full text

A genetic risk score of alleles related to MGUS interacts with socioeconomic position in a population-based cohort by Baak, Lisa, Frank, Mirjam, Dürig, Jan, Dührsen, Ulrich, Hoffmann, Per, Nöthen, Markus M., Dragano, Nico, Erbel, Raimund, Jöckel, Karl-Heinz, Schmidt, Börge

“…Environmental, genetic, and social factors are suggested to jointly influence monoclonal gammopathy of undetermined significance (MGUS), a precursor of…”
Get full text

Risk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study by Pechlivanis, Sonali, Lehmann, Nils, Hoffmann, Per, Nöthen, Markus M, Jöckel, Karl-Heinz, Erbel, Raimund, Moebus, Susanne

“…A Genetic risk score for coronary artery disease (CAD) improves the ability of predicting coronary heart disease (CHD). It is unclear whether i) the use of a…”
Get full text