Search Results - "Hoffmann, Magnus A.G."

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies by Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal…”
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In vitro characterization of engineered red blood cells as viral traps against HIV-1 and SARS-CoV-2 by Hoffmann, Magnus A.G., Kieffer, Collin, Bjorkman, Pamela J.

“…Engineered red blood cells (RBCs) expressing viral receptors could be used therapeutically as viral traps, as RBCs lack nuclei and other organelles required…”
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ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines by Hoffmann, Magnus A.G., Yang, Zhi, Huey-Tubman, Kathryn E., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Nakatomi, Leesa M., Storm, Kaya N., Moon, Woohyun J., Lin, Paulo J.C., West, Anthony P., Bjorkman, Pamela J.

“…Prime-boost regimens for COVID-19 vaccines elicit poor antibody responses against Omicron-based variants and employ frequent boosters to maintain antibody…”
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Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells by Hoffmann, Magnus A. G., Bar-On, Yotam, Yang, Zhi, Gristick, Harry B., Gnanapragasam, Priyanthi N. P., Vielmetter, Jost, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…CD4-based decoy approaches against HIV-1 are attractive options for long-term viral control, but initial designs, including soluble CD4 (sCD4) and CD4-Ig, were…”
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Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer by Yang, Zhi, Dam, Kim-Marie A., Bridges, Michael D., Hoffmann, Magnus A. G., DeLaitsch, Andrew T., Gristick, Harry B., Escolano, Amelia, Gautam, Rajeev, Martin, Malcolm A., Nussenzweig, Michel C., Hubbell, Wayne L., Bjorkman, Pamela J.

“…Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing…”
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Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env by Escolano, Amelia, Gristick, Harry B, Gautam, Rajeev, DeLaitsch, Andrew T, Abernathy, Morgan E, Yang, Zhi, Wang, Haoqing, Hoffmann, Magnus A G, Nishimura, Yoshiaki, Wang, Zijun, Koranda, Nicholas, Kakutani, Leesa M, Gao, Han, Gnanapragasam, Priyanthi N P, Raina, Henna, Gazumyan, Ana, Cipolla, Melissa, Oliveira, Thiago Y, Ramos, Victor, Irvine, Darrell J, Silva, Murillo, West, Jr, Anthony P, Keeffe, Jennifer R, Barnes, Christopher O, Seaman, Michael S, Nussenzweig, Michel C, Martin, Malcolm A, Bjorkman, Pamela J

“…Broadly neutralizing antibodies (bNAbs) against HIV-1 develop after prolonged virus and antibody coevolution. Previous studies showed that sequential…”
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CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals by Gristick, Harry B, Hartweger, Harald, Loewe, Maximilian, van Schooten, Jelle, Ramos, Victor, Oliveira, Thiago Y, Nishimura, Yoshiaki, Koranda, Nicholas S, Wall, Abigail, Yao, Kai-Hui, Poston, Daniel, Gazumyan, Anna, Wiatr, Marie, Horning, Marcel, Keeffe, Jennifer R, Hoffmann, Magnus A G, Yang, Zhi, Abernathy, Morgan E, Dam, Kim-Marie A, Gao, Han, Gnanapragasam, Priyanthi N P, Kakutani, Leesa M, Pavlovitch-Bedzyk, Ana Jimena, Seaman, Michael S, Howarth, Mark, McGuire, Andrew T, Stamatatos, Leonidas, Martin, Malcolm A, West, Jr, Anthony P, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Passive transfer of broadly neutralizing anti-HIV-1 antibodies (bNAbs) protects against infection, and therefore, eliciting bNAbs by vaccination is a major…”
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