Search Results - "Hoffmann, Inga"

Discovery of a linoleate 9S-dioxygenase and an allene oxide synthase in a fusion protein of Fusarium oxysporum[S] by Hoffmann, Inga, Oliw, Ernst H.

“…Fusarium oxysporum is a devastating plant pathogen that oxidizes C18 fatty acids sequentially to jasmonates. The genome codes for putative dioxygenase…”
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Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer by Hoffmann, Inga, Dragomir, Mihnea P., Monjé, Nanna, Keunecke, Carlotta, Kunze, Catarina Alisa, Schallenberg, Simon, Marchenko, Sofya, Schmitt, Wolfgang D., Kulbe, Hagen, Sehouli, Jalid, Braicu, Ioana Elena, Jank, Paul, Denkert, Carsten, Darb-Esfahani, Silvia, Horst, David, Sinn, Bruno V., Sers, Christine, Bischoff, Philip, Taube, Eliane T.

“…The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays a crucial role in regulating the immune system's response to tumors, but its exact role in cancer,…”
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Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes[S] by Hoffmann, Inga, Jernerén, Fredrik, Oliw, Ernst H.

“…The genome of the rice blast fungus Magnaporthe oryzae codes for two proteins with N-terminal dioxygenase (DOX) and C-terminal cytochrome P450 (CYP) domains,…”
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The role of histone demethylases in cancer therapy by Hoffmann, Inga, Roatsch, Martin, Schmitt, Martin L., Carlino, Luca, Pippel, Martin, Sippl, Wolfgang, Jung, Manfred

“…Reversible histone methylation has emerged in the last few years as an important mechanism of epigenetic regulation. Histone methyltransferases and…”
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The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases by Roatsch, Martin, Hoffmann, Inga, Abboud, Martine I, Hancock, Rebecca L, Tarhonskaya, Hanna, Hsu, Kuo-Feng, Wilkins, Sarah E, Yeh, Tzu-Lan, Lippl, Kerstin, Serrer, Kerstin, Moneke, Isabelle, Ahrens, Theresa D, Robaa, Dina, Wenzler, Sandra, Barthes, Nicolas P. F, Franz, Henriette, Sippl, Wolfgang, Lassmann, Silke, Diederichs, Sven, Schleicher, Erik, Schofield, Christopher J, Kawamura, Akane, Schüle, Roland, Jung, Manfred

“…Fe­(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are “epigenetic eraser” enzymes involved in the…”
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High EVI1 and PARP1 expression as favourable prognostic markers in high-grade serous ovarian carcinoma by Jank, Paul, Leichsenring, Jonas, Kolb, Svenja, Hoffmann, Inga, Bischoff, Philip, Kunze, Catarina Alisa, Dragomir, Mihnea P, Gleitsmann, Moritz, Jesinghaus, Moritz, Schmitt, Wolfgang D, Kulbe, Hagen, Sers, Christine, Stenzinger, Albrecht, Sehouli, Jalid, Braicu, Ioana Elena, Westhoff, Christina, Horst, David, Denkert, Carsten, Gröschel, Stefan, Taube, Eliane T

“…Mechanisms of development and progression of high-grade serous ovarian cancer (HGSOC) are poorly understood. EVI1 and PARP1, part of TGF-ß pathway, are…”
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Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases by Oliw, Ernst H., Wennman, Anneli, Hoffmann, Inga, Garscha, Ulrike, Hamberg, Mats, Jernerén, Fredrik

“…Seven Z-octadecenoic acids having the double bond located in positions 6Z to 13Z were photooxidized. The resulting hydroperoxy-E-octadecenoic acids [HpOME(E)]…”
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DNA methylation-based classification of sinonasal tumors by Jurmeister, Philipp, Glöß, Stefanie, Roller, Renée, Leitheiser, Maximilian, Schmid, Simone, Mochmann, Liliana H., Payá Capilla, Emma, Fritz, Rebecca, Dittmayer, Carsten, Friedrich, Corinna, Thieme, Anne, Keyl, Philipp, Jarosch, Armin, Schallenberg, Simon, Bläker, Hendrik, Hoffmann, Inga, Vollbrecht, Claudia, Lehmann, Annika, Hummel, Michael, Heim, Daniel, Haji, Mohamed, Harter, Patrick, Englert, Benjamin, Frank, Stephan, Hench, Jürgen, Paulus, Werner, Hasselblatt, Martin, Hartmann, Wolfgang, Dohmen, Hildegard, Keber, Ursula, Jank, Paul, Denkert, Carsten, Stadelmann, Christine, Bremmer, Felix, Richter, Annika, Wefers, Annika, Ribbat-Idel, Julika, Perner, Sven, Idel, Christian, Chiariotti, Lorenzo, Della Monica, Rosa, Marinelli, Alfredo, Schüller, Ulrich, Bockmayr, Michael, Liu, Jacklyn, Lund, Valerie J., Forster, Martin, Lechner, Matt, Lorenzo-Guerra, Sara L., Hermsen, Mario, Johann, Pascal D., Agaimy, Abbas, Seegerer, Philipp, Koch, Arend, Heppner, Frank, Pfister, Stefan M., Jones, David T. W., Sill, Martin, von Deimling, Andreas, Snuderl, Matija, Müller, Klaus-Robert, Forgó, Erna, Howitt, Brooke E., Mertins, Philipp, Klauschen, Frederick, Capper, David

“…The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities…”
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Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alterations by Jurmeister, Philipp, Wrede, Niklas, Hoffmann, Inga, Vollbrecht, Claudia, Heim, Daniel, Hummel, Michael, Wolkenstein, Peggy, Koch, Ines, Heynol, Verena, Schmitt, Wolfgang Daniel, Thieme, Anne, Teichmann, Daniel, Sers, Christine, Deimling, Andreas, Thierauf, Julia Cara, Laffert, Maximilian, Klauschen, Frederick, Capper, David

“…Cutaneous, ocular, and mucosal melanomas are histologically indistinguishable tumors that are driven by a different spectrum of genetic alterations. With…”
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Comparative investigation of cell cycle and immunomodulatory genes in mucosal and cutaneous melanomas: Preliminary data suggest a potential promising clinical role for p16 and the PD-1/PD-L1 axis by Wrede, Niklas, Hoffmann, Inga, Vollbrecht, Claudia, Koch, Ines, Wolkenstein, Peggy, Klauschen, Frederick, Capper, David, von Laffert, Maximilian, Jurmeister, Philipp

“…Mucosal melanomas arise from the mucosal lining of various organs. Their etiology is currently unknown and there are no tissue-based methods to differentiate…”
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7,8- And 5,8-linoleate diol synthases support the heterolytic scission of oxygen–oxygen bonds by different amide residues by Hoffmann, Inga, Oliw, Ernst H.

“…•P450 domains of linoleate diol synthases (LDS) isomerize hydroperoxides to diols.•LDS contain a conserved sequence Asn-Xaa-Xaa-Gln in their P450…”
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Expression of Fusion Proteins of Aspergillus terreus Reveals a Novel Allene Oxide Synthase by Hoffmann, Inga, Jernerén, Fredrik, Oliw, Ernst H.

“…Aspergilli oxidize C18 unsaturated fatty acids by dioxygenase-cytochrome P450 fusion proteins to signal molecules involved in reproduction and host-pathogen…”
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LRP1B—a prognostic marker in tubo-ovarian high-grade serous carcinoma by Kolb, Svenja, Hoffmann, Inga, Monjé, Nanna, Dragomir, Mihnea P., Jank, Paul, Bischoff, Philip, Keunecke, Carlotta, Pohl, Jonathan, Kunze, Catarina Alisa, Marchenko, Sofya, Schmitt, Wolfgang D., Kulbe, Hagen, Sers, Christine, Sehouli, Jalid, Braicu, Elena Ioana, Denkert, Carsten, Darb-Esfahani, Silvia, Horst, David, Sinn, Bruno V., Taube, Eliane T.

“…Low-density lipoprotein (LDL) receptor-related protein 1B (LRP1B) is a member of the LDL receptor family and has often been discussed as a tumor suppressor…”
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Self-reported exhaustion and a 4-item physical frailty index to predict the incidence of major complications after onco-geriatric surgery by Scholtz, Kathrin, Borchers, Friedrich, Mörgeli, Rudolf, Krampe, Henning, Schmidt, Maren, Eckardt-Felmberg, Rahel, von dossow, Vera, Sehouli, Jalid, Stief, Christian G., Pohrt, Anne, Spies, Claudia D., Weiß-Gerlach, Edith, Al-Hashem, Anwar, Braun, Susanne, Brinkmann, Frederik, Collette, Anna-Maria, Degel, Franziska, de Beukelaer, Frederic, Geue, Susanne, Hartmann, Kerstin, Hennig, Saskia, Hoffmann, Inga, Mohr, Oskar, Petrov, Georgi

“…The aim of this study was to analyze four pre-operative physical frailty indicators from a geriatric assessment (GA) independently and combined in a physical…”
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AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication by Monjé, Nanna, Dragomir, Mihnea P., Sinn, Bruno V., Hoffmann, Inga, Makhmut, Anuar, Simon, Tincy, Kunze, Catarina A., Ihlow, Jana, Schmitt, Wolfgang D., Pohl, Jonathan, Piwonski, Iris, Marchenko, Sofya, Keunecke, Carlotta, Calina, Teodor G., Tiso, Francesca, Kulbe, Hagen, Kreuzinger, Caroline, Cacsire Castillo-Tong, Dan, Sehouli, Jalid, Braicu, Elena I., Denkert, Carsten, Darb-Esfahani, Silvia, Kübler, Kirsten, Capper, David, Coscia, Fabian, Morkel, Markus, Horst, David, Sers, Christine, Taube, Eliane T.

“…Background The aim of this study was to analyse transcriptomic differences between primary and recurrent high-grade serous ovarian carcinoma (HGSOC) to…”
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Prognostic value of regulatory T cells and T helper 17 cells in high grade serous ovarian carcinoma by Marchenko, Sofya, Piwonski, Iris, Hoffmann, Inga, Sinn, Bruno Valentin, Kunze, Catarina Alisa, Monjé, Nanna, Pohl, Jonathan, Kulbe, Hagen, Schmitt, Wolfgang Daniel, Darb-Esfahani, Sylvia, Braicu, Elena Ioana, von Brünneck, Ann-Christin, Sehouli, Jalid, Denkert, Carsten, Horst, David, Jöhrens, Korinna, Taube, Eliane Tabea

“…Purpose In recent years the tumor microenvironment and its interaction with the tumor has emerged into research focus with increased attention to the…”
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Proficiency testing of PIK3CA mutations in HR+/HER2-breast cancer on liquid biopsy and tissue by Vollbrecht, Claudia, Hoffmann, Inga, Lehmann, Annika, Merkelbach-Bruse, Sabine, Fassunke, Jana, Wagener-Ryczek, Svenja, Ball, Markus, Dimitrova, Lora, Hartmann, Arndt, Stöhr, Robert, Erber, Ramona, Weichert, Wilko, Pfarr, Nicole, Bohlmann, Lisa, Jung, Andreas, Dietmaier, Wolfgang, Dietel, Manfred, Horst, David, Hummel, Michael

“…Precision oncology based on specific molecular alterations requires precise and reliable detection of therapeutic targets in order to initiate the optimal…”
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Anticholinergic burden of long-term medication is an independent risk factor for the development of postoperative delirium: A clinical trial by Mueller, Anika, Spies, Claudia D., Eckardt, Rahel, Weiss, Bjoern, Pohrt, Anne, Wernecke, Klaus-Dieter, Schmidt, Maren

“…Postoperative delirium (POD) is a common complication after surgery. We sought to determine the association between preoperative anticholinergic load…”
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Low Expression of RGS2 Promotes Poor Prognosis in High-Grade Serous Ovarian Cancer by Ihlow, Jana, Monjé, Nanna, Hoffmann, Inga, Bischoff, Philip, Sinn, Bruno Valentin, Schmitt, Wolfgang Daniel, Kunze, Catarina Alisa, Darb-Esfahani, Sylvia, Kulbe, Hagen, Braicu, Elena Ioana, Sehouli, Jalid, Denkert, Carsten, Horst, David, Taube, Eliane Tabea

“…RGS2 regulates G-protein signaling by accelerating hydrolysis of GTP and has been identified as a potentially druggable target in carcinomas. Since the…”
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Manganese lipoxygenase oxidizes bis-allylic hydroperoxides and octadecenoic acids by different mechanisms by Oliw, Ernst H., Jernerén, Fredrik, Hoffmann, Inga, Sahlin, Margareta, Garscha, Ulrike

“…Manganese lipoxygenase (MnLOX) oxidizes (11 R)-hydroperoxylinolenic acid (11 R-HpOTrE) to a peroxyl radical. Our aim was to compare the enzymatic oxidation of…”
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