Search Results - "Hoffmann, FuKun W."

MsrB1 and MICALs Regulate Actin Assembly and Macrophage Function via Reversible Stereoselective Methionine Oxidation by Lee, Byung Cheon, Péterfi, Zalán, Hoffmann, FuKun W., Moore, Richard E., Kaya, Alaattin, Avanesov, Andrei, Tarrago, Lionel, Zhou, Yani, Weerapana, Eranthie, Fomenko, Dmitri E., Hoffmann, Peter R., Gladyshev, Vadim N.

“…Redox control of protein function involves oxidation and reduction of amino acid residues, but the mechanisms and regulators involved are insufficiently…”
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Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex by Fredericks, Gregory J., Hoffmann, FuKun W., Rose, Aaron H., Osterheld, Hanna J., Hess, Franz M., Mercier, Frederic, Hoffmann, Peter R.

“…Significance The stimulation of certain surface receptors on immune cells triggers the release of calcium (Ca ²⁺) stored in the endoplasmic reticulum (ER)…”
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Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses by Verma, Saguna, Hoffmann, FuKun W, Kumar, Mukesh, Huang, Zhi, Roe, Kelsey, Nguyen-Wu, Elizabeth, Hashimoto, Ann S, Hoffmann, Peter R

“…Selenoprotein K (Sel K) is a selenium-containing protein for which no function has been identified. We found that Sel K is an endoplasmic reticulum…”
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Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis by Meiler, Svenja, Baumer, Yvonne, Huang, Zhi, Hoffmann, Fukun W., Fredericks, Gregory J., Rose, Aaron H., Norton, Robert L., Hoffmann, Peter R., Boisvert, William A.

“…CD36 requires palimitoylation in a selenoprotein K‐dependent manner, to localize lipid rafts and function properly. Selk is an ER transmembrane protein…”
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Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation by Ma, Chi, Hoffmann, FuKun W., Marciel, Michael P., Page, Kathleen E., Williams-Aduja, Melodie A., Akana, Ellis N.L., Gojanovich, Greg S., Gerschenson, Mariana, Urschitz, Johann, Moisyadi, Stefan, Khadka, Vedbar S., Rozovsky, Sharon, Deng, Youping, Horgen, F. David, Hoffmann, Peter R.

“…T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine…”
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Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion by Bertino, Pietro, Premeaux, Thomas A., Fujita, Tsuyoshi, Haun, Brien K., Marciel, Michael P., Hoffmann, Fukun W., Garcia, Alan, Yiang, Haining, Pastorino, Sandra, Carbone, Michele, Niki, Toshiro, Berestecky, John, Hoffmann, Peter R., Ndhlovu, Lishomwa C.

“…Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In…”
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Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models by Hoffmann, Peter R, Hoffmann, Fukun W, Premeaux, Thomas A, Fujita, Tsuyoshi, Soprana, Elisa, Panigada, Maddalena, Chew, Glen M, Richard, Guilhem, Hindocha, Pooja, Menor, Mark, Khadka, Vedbar S, Deng, Youping, Moise, Lenny, Ndhlovu, Lishomwa C, Siccardi, Antonio, Weinberg, Andrew D, De Groot, Anne S, Bertino, Pietro

“…Malignant Mesothelioma (MM) is a rare and highly aggressive cancer that develops from mesothelial cells lining the pleura and other internal cavities, and is…”
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Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate by Fredericks, Gregory J, Hoffmann, FuKun W, Hondal, Robert J, Rozovsky, Sharon, Urschitz, Johann, Hoffmann, Peter R

“…Selenoprotein K (SELENOK) is a selenocysteine (Sec)-containing protein localized in the endoplasmic reticulum (ER) membrane where it interacts with the DHHC6…”
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Depletion of monocytic myeloid-derived suppressor cells in LP-BM5 murine retroviral infection has a positive impact on virus-induced host immunodeficiency by Green, Kathy A., Ma, Chi, Hoffmann, Fukun W., Hoffmann, Peter R., Green, William R.

“…We have shown the induction of CD11b+Ly6C+ monocytic myeloid-derived suppressor cells (M-MDSCs) during infection of B6 mice by LP-BM5 immunodeficiency-inducing…”
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Selenoprotein I is essential for murine embryogenesis by Avery, Joseph C., Yamazaki, Yukiko, Hoffmann, FuKun W., Folgelgren, Benjamin, Hoffmann, Peter R.

“…Selenoprotein I (SELENOI) is an ethanolamine phosphotransferase that catalyzes the third reaction of the Kennedy pathway for the synthesis of…”
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Upregulated selenoprotein I during lipopolysaccharide-induced B cell activation promotes lipidomic changes and is required for effective differentiation into IgM-secreting plasma B cells by Ma, Chi, Hoffmann, FuKun W, Shay, Ashley E, Koo, Imhoi, Green, Kathy A, Green, William R, Hoffmann, Peter R

“…Abstract The mechanisms driving metabolic reprogramming during B cell activation are unclear, particularly roles for enzymatic pathways involved in lipid…”
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Selenoprotein I is indispensable for ether lipid homeostasis and proper myelination by Nunes, Lance G.A., Ma, Chi, Hoffmann, FuKun W., Shay, Ashley E., Pitts, Matthew W., Hoffmann, Peter R.

“…Selenoprotein I (SELENOI) catalyzes the final reaction of the CDP-ethanolamine branch of the Kennedy pathway, generating the phospholipids…”
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Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology by Ma, Chi, Hoffmann, FuKun W., Nunes, Lance G., Urena, Frank, Andrukhiv, Anastasia, Gerschenson, Mariana, Pitts, Matthew W., Hoffmann, Peter R.

“…Selenoprotein I (SELENOI) is an ethanolamine phospholipid transferase contributing to cellular metabolism and the synthesis of glycosylphosphatidylinositol…”
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Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols by Hoffmann, FuKun W, Hashimoto, Ann C, Shafer, Leigh Anne, Dow, Steven, Berry, Marla J, Hoffmann, Peter R

“…The immune-enhancing effects of selenium (Se) supplementation make it a promising complementary and alternative medicine modality for boosting immunity,…”
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Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient FcγR‐mediated phagocytosis by Norton, Robert L., Fredericks, Gregory J., Huang, Zhi, Fay, Jeffrey D., Hoffmann, FuKun W., Hoffmann, Peter R.

“…Effective activation of macrophages through phagocytic Fcγ receptors (FcγR) has been shown to require selenoprotein K (Selk). We set out to determine whether…”
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T-cell activation decreases miRNA-15a/16 levels to promote MEK1–ERK1/2–Elk1 signaling and proliferative capacity by Urena, Frank, Ma, Chi, Hoffmann, FuKun W., Nunes, Lance G.A., Urschitz, Johann, Moisyadi, Stefan, Khadka, Vedbar S., Deng, Youping, Hoffmann, Peter R.

“…While miRs have been extensively studied in the context of malignancy and tumor progression, their functions in regulating T-cell activation are less clear. In…”
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Increasing Dietary Selenium Elevates Reducing Capacity and ERK Activation Associated with Accelerated Progression of Select Mesothelioma Tumors by Rose, Aaron H, Bertino, Pietro, Hoffmann, FuKun W, Gaudino, Giovanni, Carbone, Michele, Hoffmann, Peter R

“…To study the effect of the micronutrient selenium on malignant mesothelioma (MM) progression, we cultured four different MM cell lines in media containing…”
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Selenoprotein K Is a Novel Target of m-Calpain, and Cleavage Is Regulated by Toll-like Receptor-induced Calpastatin in Macrophages by Huang, Zhi, Hoffmann, FuKun W., Norton, Robert L., Hashimoto, Ann C., Hoffmann, Peter R.

“…Calpains are proteolytic enzymes that modulate cellular function through cleavage of targets, thereby modifying their actions. An important role is emerging…”
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Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis by Huang, Zhi, Rose, Aaron H, Hoffmann, FuKun W, Hashimoto, Ann S, Bertino, Pietro, Denk, Tobias, Takano, Jiro, Iwata, Nobuhisa, Saido, Takaomi C, Hoffmann, Peter R

“…Calpain enzymes proteolytically modulate cellular function and have been implicated in inflammatory diseases. In this study, we found that calpain levels did…”
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selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply by Hoffmann, Peter R, Höge, Simone C, Li, Ping-An, Hoffmann, Fukun W, Hashimoto, Ann C, Berry, Marla J

“…Selenoprotein P (Sel P) is a selenium-rich glycoprotein believed to play a key role in selenium (Se) transport throughout the body. Development of a Sel P…”
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