Search Results - "Hoffman, P. L."

Effects of Moderate Alcohol Consumption on the Central Nervous System by Eckardt, Michael J., File, Sandra E., Gessa, Gian Luigi, Grant, Kathleen A., Guerri, Consuelo, Hoffman, Paula L., Kalant, Harold, Koob, George F., Li, Ting-Kai, Tabakoff, Boris

“…The concept of moderate consumption of ethanol (beverage alcohol) has evolved over time from considering this level of intake to be nonintoxicating and…”
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Ethanol Promotes Apoptosis in Cerebellar Granule Cells by Inhibiting the Trophic Effect of NMDA by Bhave, Sanjiv V., Hoffman, Paula L.

“…: When primary cultures of cerebellar granule neurons are grown in a physiological concentration of KCl (5 mM) they undergo apoptosis, which can be prevented…”
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ALCOHOL DEPENDENCE: A COMMENTARY ON MECHANISMS by HOFFMAN, PAULA L., TABAKOFF, BORIS

“…The alcohol dependence syndrome includes the presence of alcohol tolerance, physical dependence and an inability to control one's alcohol intake. Studies are…”
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Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function by Iorio, K R, Reinlib, L, Tabakoff, B, Hoffman, P L

“…In primary cultures of cerebellar granule cells, activation of the N-methyl-D-aspartate (NMDA) receptor leads to Ca2+ influx. Previous work showed that this…”
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Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal by Gulya, K, Grant, K A, Valverius, P, Hoffman, P L, Tabakoff, B

“…Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol…”
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N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production by Hoffman, P L, Rabe, C S, Moses, F, Tabakoff, B

“…Measurements of calcium uptake and cyclic GMP production by cerebellar granule cells grown in primary culture demonstrated that ethanol preferentially…”
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Genetics of gene expression characterizes response to selective breeding for alcohol preference by Hoffman, P. L., Saba, L. M., Flink, S., Grahame, N. J., Kechris, K., Tabakoff, B.

“…Numerous selective breeding experiments have been performed with rodents, in an attempt to understand the genetic basis for innate differences in preference…”
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Ethanol and guanine nucleotide binding proteins: a selective interaction by Hoffman, P L, Tabakoff, B

“…Guanine nucleotide binding proteins (G proteins) play key roles in signal transduction, including the coupling of hormone and neurotransmitter receptors to…”
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Glutamate receptors in alcohol withdrawal-induced neurotoxicity by HOFFMAN, P. L

“…Chronic ethanol ingestion results in an "up-regulation" of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in mouse brain. This increase in…”
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Chronic ethanol exposure results in increased acute functional tolerance in selected lines of HAFT and LAFT mice by WU, Peter H, TABAKOFF, Boris, SZABO, Gyula, HOFFMAN, Paula L

“…Functional (pharmacodynamic) ethanol tolerance can be evidenced within a single session of exposure to ethanol (acute or within-session tolerance), or after…”
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Chronic Ethanol Exposure Attenuates the Anti‐Apoptotic Effect of NMDA in Cerebellar Granule Neurons by Bhave, Sanjiv V., Snell, Lawrence D., Tabakoff, Boris, Hoffman, Paula L.

“…: Ethanol, added to primary cultures of cerebellar granule neurons simultaneously with NMDA, was previously shown to inhibit the anti‐apoptotic effect of NMDA…”
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The Characterization of a Novel Human Adenylyl Cyclase Which Is Present in Brain and Other Tissues by Hellevuo, Kaisa, Yoshimura, Masami, Hoffman, Paula L., Cooper, Dermot M.F., Tabakoff, Boris, Mons, Nicole

“…We characterized a human cDNA clone which encodes a novel adenylyl cyclase. Data from Southern and Northern blot analysis, and analysis of sequence similarity…”
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Converting tribology principles into measurable maintenance improvements at Sishen Iron Ore Mine by Hoffman, P.L

“…Sishen Iron Ore Mine in the Northern Cape province of South Africa utilises 72 primary equipment units to move 119Mt of materials per year, of which 32.5Mt of…”
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Glutamate-induced neurotoxicity is increased in cerebellar granule cells exposed chronically to ethanol by Iorio, K R, Tabakoff, B, Hoffman, P L

“…Chronic exposure of primary cultures of cerebellar granule cells to ethanol has previously been shown to result in an enhanced response of the cells to…”
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Immunological assessment of the distribution of Type VII adenylyl cyclase in brain by Mons, Nicole, Yoshimura, Masami, Ikeda, Hiroshi, Hoffman, Paula L, Tabakoff, Boris

“…The localization of the nine identified isoforms of adenylyl cyclase in brain has been largely based on determination of patterns of mRNA expression. A…”
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Differences in platelet enzyme activity between alcoholics and nonalcoholics by Tabakoff, B, Hoffman, P L, Lee, J M, Saito, T, Willard, B, De Leon-Jones, F

“…Blood platelets are an accessible tissue that reflects the activity of many enzymes found in the brain. To investigate the possible effect on such enzymes of…”
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Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells by Snell, L D, Tabakoff, B, Hoffman, P L

“…Ethanol inhibits N-methyl-D-aspartate (NMDA)-stimulated increases in intracellular Ca2+ in cerebellar granule cells apparently by reducing the potency of…”
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Role of Protein Kinase C in Ethanol-Induced Activation of Adenylyl Cyclase by Rabbani, Mohammed, Nelson, Eric J., Hoffman, Paula L., Tabakoff, Boris

“…Ethanol is known to enhance the activity of adenylyl cyclase (AC) in a number of cells and tissues. Recent work has suggested that the various isoforms of AC…”
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Ethanol sensitivity of NMDA receptor function in developing cerebellar granule neurons by Bhave, Sanjiv V, Snell, Lawrence D, Tabakoff, Boris, Hoffman, Paula L

“…The mechanism by which ethanol inhibits the function of the NMDA subtype of glutamate receptor has not been elucidated. One possibility that has been suggested…”
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Adenylyl cyclases: mRNA and characteristics of enzyme activity in three areas of brain by Hellevuo, K, Hoffman, P L, Tabakoff, B

“…RNase protection assays were used in a comparative analysis of the quantities of mRNA for five "calcium-sensitive" (types I, III, V, VI, and VIII) adenylyl…”
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