Search Results - "Hoffman, Maureane"

Hypothesis: Hyperhomocysteinemia is an indicator of oxidant stress by Hoffman, Maureane

“…Abstract Elevated plasma homocysteine levels are associated with an increased risk of atherosclerosis and thrombosis, as well as a variety of other pathologies…”
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Thrombosis and novel hemophilia therapies: the fine line between clotting and bleeding by Hoffman, Maureane

“…The availability of novel nonfactor therapeutics is revolutionizing the management of hemophilia in individuals with inhibitory antibodies, as well as making…”
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Trauma-induced coagulopathy by Moore, Ernest E., Moore, Hunter B., Kornblith, Lucy Z., Neal, Matthew D., Hoffman, Maureane, Mutch, Nicola J., Schöchl, Herbert, Hunt, Beverley J., Sauaia, Angela

“…Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic injury. Trauma-induced coagulopathy (TIC) describes abnormal…”
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Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways by Noubouossie, Denis F., Henderson, Michael W., Mooberry, Micah, Ilich, Anton, Ellsworth, Patrick, Piegore, Mark, Skinner, Sarah C., Pawlinski, Rafal, Welsby, Ian, Renné, Thomas, Hoffman, Maureane, Monroe, Dougald M., Key, Nigel S.

“…Storage lesion–induced, red cell–derived microvesicles (RBC-MVs) propagate coagulation by supporting the assembly of the prothrombinase complex. It has also…”
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A cell-based model of coagulation and the role of factor VIIa by Hoffman, Maureane

“…Our cell-based model of haemostasis replaces the traditional ‘cascade’ hypothesis, and proposes that coagulation takes place on different cell surfaces in…”
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Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin by Ansell, Jack E, Laulicht, Bryan E, Bakhru, Sasha H, Hoffman, Maureane, Steiner, Solomon S, Costin, James C

“…Abstract Major bleeding with low molecular weight heparin (LMWH) therapy occurs in up to 5% of patients and its anticoagulation is only partially reversed by…”
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Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels by Nimjee, Shahid M., Dornbos, David, Pitoc, George A., Wheeler, Debra G., Layzer, Juliana M., Venetos, Nicholas, Huttinger, Allyson, Talentino, Spencer E., Musgrave, Nicholas J., Moody, Holly, Rempel, Rachel E., Jones, Cheyenne, Carlisle, Kendyl, Wilson, Jenna, Bratton, Camille, Joseph, Matthew E., Khan, Shoeb, Hoffman, Maureane R., Sommerville, Laura, Becker, Richard C., Zweier, Jay L., Sullenger, Bruce A.

“…Endothelial surface and circulating glycoprotein von Willebrand factor (vWF) regulates platelet adhesion and is associated with thrombotic diseases, including…”
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Inhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury by Lei, Beilei, Wang, Chaojian, Snow, Kamie, Graton, Murilo E., Tighe, Robert M., Fager, Ammon M., Hoffman, Maureane R., Giangrande, Paloma H., Miller, Francis J.

“…Acute lung injury (ALI) is a syndrome of acute inflammation, barrier disruption, and hypoxemic respiratory failure associated with high morbidity and…”
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Platelets and Thrombin Generation by Monroe, Dougald M, Hoffman, Maureane, Roberts, Harold R

“…ABSTRACT—This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin…”
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Coagulation disorders and hemostasis in liver disease: Pathophysiology and critical assessment of current management by Caldwell, Stephen H., Hoffman, Maureane, Lisman, Ton, Macik, B. Gail, Northup, Patrick G., Reddy, K. Rajender, Tripodi, Armando, Sanyal, Arun J.

“…Normal coagulation has classically been conceptualized as a Y‐shaped pathway, with distinct “intrinsic” and “extrinsic” components initiated by factor XII or…”
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The clotting system - a major player in wound healing by MONROE, DOUGALD M., HOFFMAN, MAUREANE

“…Wound healing involves a complex series of interactions between coagulation, inflammation, angiogenesis, and cellular migration and proliferation. Our…”
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A cell-based model of hemostasis by Hoffman, M, Monroe, 3rd, D M

“…Based on our work and that of many other workers, we have developed a model of coagulation in vivo. Many workers have demonstrated mechanisms by which cells…”
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Low intensity laser therapy speeds wound healing in hemophilia by enhancing platelet procoagulant activity by Hoffman, Maureane, Monroe, Dougald M.

“…Our group has previously shown that cutaneous wound healing is delayed and histologically abnormal in a mouse model of hemophilia. Hemostasis is not only…”
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The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review by Hoffman, Maureane, Goldstein, Joshua N., Levy, Jerrold H.

“…Background Bleeding complications are a risk associated with all anticoagulants. Currently, the treatment options for the management of direct oral…”
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Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors by Koh, Cho Yeow, Shih, Norrapat, Yip, Christina Y. C., Li, Aaron Wei Liang, Chen, Weiming, Amran, Fathiah S., Leong, Esther Jia En, Iyer, Janaki Krishnamoorthy, Croft, Grace, Mazlan, Muhammad Ibrahim Bin, Chee, Yen-Lin, Yap, Eng-Soo, Monroe, Dougald M., Hoffman, Maureane, Becker, Richard C., de Kleijn, Dominique P. V., Verma, Vaishali, Gupta, Amita, Chaudhary, Vijay K., Richards, A. Mark, Kini, R. Manjunatha, Chan, Mark Y.

“…Despite their limitations, unfractionated heparin (UFH) and bivalirudin remain standard-of-care parenteral anticoagulants for percutaneous coronary…”
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Biology of Coagulation and Coagulopathy in Neurologic Surgery by Fager, Ammon M., MD, PhD, Hoffman, Maureane, MD, PhD

“…Hemostasis is a cell-based process that is regulated in a tissue-specific manner by the differential expression of procoagulant and anticoagulant factors on…”
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Author Correction: Trauma-induced coagulopathy by Moore, Ernest E., Moore, Hunter B., Kornblith, Lucy Z., Neal, Matthew D., Hoffman, Maureane, Mutch, Nicola J., Schöchl, Herbert, Hunt, Beverley J., Sauaia, Angela

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The Coagulation Cascade in Cirrhosis by Monroe, Dougald M., PhD, Hoffman, Maureane, MD, PhD

“…The coagulation “cascade” model accurately represents the mechanisms of the prothrombin time and activated partial thromboplastin time tests. However, these…”
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Modification of Fibrinogen by Homocysteine Thiolactone Increases Resistance to Fibrinolysis:  A Potential Mechanism of the Thrombotic Tendency in Hyperhomocysteinemia by Sauls, Derrick L, Lockhart, Evelyn, Warren, Maria Esteban, Lenkowski, Angela, Wilhelm, Susan E, Hoffman, Maureane

“…We have previously shown functional differences in fibrinogen from hyperhomocysteinemic rabbits compared to that in control rabbits. This acquired…”
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Differentiating between cold agglutinins and rouleaux: a case series of seven patients by Heath, Michele, Walker, Julie, Barbeito, Atilio, Williams, Adam, Welsby, Ian, Maxwell, Cory, Daneshmand, Mani, Haney, John, Hoffman, Maureane

“…We present a case series of seven patients with suspected cold agglutinin antibodies, discovered after initiation of bypass. Laboratory analysis of blood…”
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