Search Results - "Hoffman, Keith L."

low blood volume LC‐MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children by Clavijo, Claudia F, Thomas, James Joseph, Cromie, Meghan, Schniedewind, Björn, Hoffman, Keith L, Christians, Uwe, Galinkin, Jeffrey L

“…Preterm and term neonates often require surgical procedures and analgesia. However, our knowledge about neonatal pharmacokinetics of fentanyl, the most…”
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Continuous administration of a selective α7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice by Stevens, Karen E, Cornejo, Brandon, Adams, Catherine E, Zheng, Lijun, Yonchek, Joan, Hoffman, Keith L, Christians, Uwe, Kem, William R

“…Abstract Stimulation of nicotinic receptors, specifically the α7 subtype, improves sensory inhibition and cognitive function in receptor deficient humans and…”
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Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography–tandem mass spectrometry by Taylor, Rachel R., Hoffman, Keith L., Schniedewind, Björn, Clavijo, Claudia, Galinkin, Jeffrey L., Christians, Uwe

“…•Comparison of assay performance in plasma, CSF and dried blood spots (DBS).•Assay performance in DBS is similar to that of acetaminophen in plasma…”
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A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography–tandem mass spectrometry by Clavijo, Claudia F., Hoffman, Keith L., Thomas, James J., Carvalho, Brendan, Chu, Larry F., Drover, David R., Hammer, Gregory B., Christians, Uwe, Galinkin, Jeffrey L.

“…Opioids such as morphine are the cornerstone of pain treatment. The challenge of measuring the concentrations of morphine and its active metabolites in order…”
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Influence of SLCO1B1 Polymorphisms on the Drug-Drug Interaction Between Darunavir/Ritonavir and Pravastatin by Aquilante, Christina L., Kiser, Jennifer J., Anderson, Peter L., Christians, Uwe, Kosmiski, Lisa A., Daily, Elizabeth B., Hoffman, Keith L., Hopley, Charles W., Predhomme, Julie A., Schniedewind, Bjorn, Sidhom, Maha S.

“…The authors investigated whether SLCO1B1 polymorphisms contribute to variability in pravastatin pharmacokinetics when pravastatin is administered alone versus…”
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Continuous administration of a selective alpha 7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice by Stevens, Karen E, Cornejo, Brandon, Adams, Catherine E, Zheng, Lijun, Yonchek, Joan, Hoffman, Keith L, Christians, Uwe, Kem, William R

“…Stimulation of nicotinic receptors, specifically the alpha 7 subtype, improves sensory inhibition and cognitive function in receptor deficient humans and…”
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Semi-automated 96-well liquid–liquid extraction for quantitation of drugs in biological fluids by Zhang, Nanyan, Hoffman, Keith L, Li, Wenlin, Rossi, David T

“…A semi-automated liquid–liquid extraction (LLE) technique for biological fluid sample preparation was introduced for the quantitation of four drugs in rat…”
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Tandem-in-Time Mass Spectrometry as a Quantitative Bioanalytical Tool by Rossi, David T, Hoffman, Keith L, Janiczek-Dolphin, Nancy, Bockbrader, Howard, Parker, Tresavon D

“…Tandem-in-time mass spectrometry, as implemented on an ion-trap detector (ITD), is the process whereby precursor ions are created, stored in a radio frequency…”
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Mixed-mechanism ionization to enhance sensitivity in atmospheric pressure ionization LC/MS by Bi, Honggang, Hoffman, Keith L, Pace, Gerry, Rossi, David T

“…A novel dual-mechanism ionization technique for LC/MS/MS has been observed, characterized and applied to the quantitation of a tertiary amine-containing drug…”
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Quantitation of a novel metalloporphyrin drug in plasma by atomic absorption spectroscopy by Hoffman, Keith L, Feng, M.Rose, Rossi, David T

“…A bioanalytical method to quantify cobalt mesoporphyrin (CoMP), a novel therapeutic agent, in plasma has been developed and validated. The approach involves…”
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A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatographytandem mass spectrometry by Clavijo, Claudia F, Hoffman, Keith L, Thomas, James J, Carvalho, Brendan, Chu, Larry F, Drover, David R, Hammer, Gregory B, Christians, Uwe, Galinkin, Jeffrey L

“…Opioids such as morphine are the cornerstone of pain treatment. The challenge of measuring the concentrations of morphine and its active metabolites in order…”
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A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children: Metabolomics by CLAVIJO, Claudia F, JOSEPH THOMAS, James, CROMIE, Meghan, SCHNIEDEWIND, Björn, HOFFMAN, Keith L, CHRISTIANS, Uwe, GALINKIN, Jeffrey L

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Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice by Stevens, Karen E, Cornejo, Brandon, Adams, Catherine E, Zheng, Lijun, Yonchek, Joan, Hoffman, Keith L, Christians, Uwe, Kem, William R

“…Stimulation of nicotinic receptors, specifically the alpha7 subtype, improves sensory inhibition and cognitive function in receptor deficient humans and…”
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Trace quantitation of the novel cholinesterase inhibitor in human plasma by capillary gas chromatography/ion trap mass spectrometry by Hoffman, Keith L., Rossi, David T., Wright, D.Scott

“…This paper demonstrates the utility of an ion trap mass spectrometer as a detector for trace quantitative determinations of pharmaceuticals in human plasma by…”
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An HPLC assay utilizing solid-phase extraction for CI-1010, an alkylating radiosensitizer, in rat plasma by Bullen, William W., Rossi, David T., Hoffman, Keith L., Suri, Ajit, Lathia, Chetan D.

“…CI-1010, a 2-nitroimidazole, is a chiral prodrug for the active moiety PD 146923 and is under development as an alkylating radiosensitizer to be used as an…”
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Monitoring data quality through comparisons between data systems by Massey, J T, Hoffman, K L

“…Since its creation in 1960, the National Center for Health Statistics (NCHS) has placed a high value on the quality of the information and statistics collected…”
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