Search Results - "Hoffman, Ann N."

Conditional and unconditional components of aversively motivated freezing, flight and darting in mice by Trott, Jeremy M, Hoffman, Ann N, Zhuravka, Irina, Fanselow, Michael S

“…Fear conditioning is one of the most frequently used laboratory procedures for modeling learning and memory generally, and anxiety disorders in particular. The…”
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Stress reactivity after traumatic brain injury: implications for comorbid post-traumatic stress disorder by Hoffman, Ann N, Taylor, Anna N

“…Most people have or will experience traumatic stress at some time over the lifespan, but only a subset of traumatized individuals develop post-traumatic stress…”
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Adaptation of Threat Responses Within the Negative Valence Framework by Smith, Nancy J, Markowitz, Sara Y, Hoffman, Ann N, Fanselow, Michael S

“…External threats are a major source of our experience of negatively valanced emotion. As a threat becomes closer and more real, our specific behavior patterns…”
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Sex-specific impairment and recovery of spatial learning following the end of chronic unpredictable restraint stress: Potential relevance of limbic GAD by Ortiz, J. Bryce, Taylor, Sara B., Hoffman, Ann N., Campbell, Alyssa N., Lucas, Louis R., Conrad, Cheryl D.

“…•In males, chronic unpredictable restraint impaired spatial learning.•Stress-induced spatial learning deficits in males improved after a recovery…”
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Cholinergic Signaling Alters Stress-Induced Sensitization of Hippocampal Contextual Learning by Hersman, Sarah, Hoffman, Ann N, Hodgins, Liliann, Shieh, Shannon, Lam, Jamie, Parikh, Ashen, Fanselow, Michael S

“…Post-traumatic stress disorder (PTSD) has a profound contextual component, and has been demonstrated to alter future contextual learning. However, the…”
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Sex Differences in Behavioral Sensitivities After Traumatic Brain Injury by Hoffman, Ann N, Watson, Sonya L, Makridis, Anna S, Patel, Anisha Y, Gonzalez, Sarah T, Ferguson, Lindsay, Giza, Christopher C, Fanselow, Michael S

“…Traumatic brain injury (TBI) is associated with high rates of post-injury psychiatric and neurological comorbidities. TBI is more common in males than females…”
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Frontoamygdala hyperconnectivity predicts affective dysregulation in adolescent moderate-severe TBI by Bickart, Kevin C, Olsen, Alexander, Dennis, Emily L, Babikian, Talin, Hoffman, Ann N, Snyder, Aliyah, Sheridan, Christopher A, Fischer, Jesse T, Giza, Christopher C, Choe, Meeryo C, Asarnow, Robert F

“…In survivors of moderate to severe traumatic brain injury (msTBI), affective disruptions often remain underdetected and undertreated, in part due to poor…”
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Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury by Kline, Anthony E., Hoffman, Ann N., Cheng, Jeffrey P., Zafonte, Ross D., Massucci, Jaime L.

“…Antipsychotics are often administered to traumatic brain injured (TBI) patients as a means of controlling agitation, albeit the rehabilitative consequences of…”
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Region-Dependent Modulation of Neural Plasticity in Limbic Structures Early after Traumatic Brain Injury by Hoffman, Ann N, Watson, Sonya, Fanselow, Michael S, Hovda, David A, Giza, Christopher

“…Traumatic brain injury (TBI)-induced disruptions in synaptic function within brain regions and across networks in the limbic system may underlie a…”
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Fear, Defense, and Emotion: A Neuroethological Understanding of the Negative Valence Research Domain Criteria by Fanselow, Michael S., Hoffman, Ann N.

“…We describe the close correspondence between predatory imminence continuum theory (PICT) and the National Institute of Mental Health's Research Domain Criteria…”
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Anxiety, fear, panic: An approach to assessing the defensive behavior system across the predatory imminence continuum by Hoffman, Ann N., Trott, Jeremy M., Makridis, Anna, Fanselow, Michael S.

“…In order to effectively thwart predation, antipredator defensive behaviors must be matched to the current spatio-temporal relationship to the predator. We have…”
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Timing and the transition between modes in the defensive behavior system by Fanselow, Michael S., Hoffman, Ann N., Zhuravka, Irina

“…•The antipredator defensive behavior system mirrors the predatory behavior system.•Short and Long CSs elicit behaviors specific to the same mode…”
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Sensory sensitivity as a link between concussive traumatic brain injury and PTSD by Hoffman, Ann N., Lam, Jamie, Hovda, David A., Giza, Christopher C., Fanselow, Michael S.

“…Traumatic brain injury (TBI) is one of the most common injuries to military personnel, a population often exposed to stressful stimuli and emotional trauma…”
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Increased Fear Generalization and Amygdala AMPA Receptor Proteins in Chronic Traumatic Brain Injury by Hoffman, Ann N, Watson, Sonya, Chavda, Nishtha, Lam, Jamie, Hovda, David A, Giza, Christopher C, Fanselow, Michael S

“…Cognitive impairments and emotional lability are common long-term consequences of traumatic brain injury (TBI). How TBI affects interactions between sensory,…”
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Early and Persistent Dendritic Hypertrophy in the Basolateral Amygdala following Experimental Diffuse Traumatic Brain Injury by Hoffman, Ann N, Paode, Pooja R, May, Hazel G, Ortiz, J Bryce, Kemmou, Salma, Lifshitz, Jonathan, Conrad, Cheryl D, Currier Thomas, Theresa

“…In the pathophysiology of traumatic brain injury (TBI), the amygdala remains understudied, despite involvement in processing emotional and stressful stimuli…”
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Chronic stress disrupts fear extinction and enhances amygdala and hippocampal Fos expression in an animal model of post-traumatic stress disorder by Hoffman, Ann N., Lorson, Nickolaus G., Sanabria, Federico, Foster Olive, M., Conrad, Cheryl D.

“…•Chronic stress increases contextual fear during extinction.•Chronic stress-enhanced fear memories generalize to a novel context.•Chronic stress enhances…”
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Chronic Stress Impairs Prefrontal Cortex-Dependent Response Inhibition and Spatial Working Memory by MIKA, Agnieszka, MAZUR, Gabriel J, HOFFMAN, Ann N, TALBOOM, Joshua S, BIMONTE-NELSON, Heather A, SANABRIA, Federico, CONRAD, Cheryl D

“…Chronic stress leads to neurochemical and structural alterations in the prefrontal cortex (PFC) that correspond to deficits in PFC-mediated behaviors. The…”
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Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury by Sozda, Christopher N, Hoffman, Ann N, Olsen, Adam S, Cheng, Jeffrey P, Zafonte, Ross D, Kline, Anthony E

“…Several studies have shown that housing rats in an enriched environment (EE) after traumatic brain injury (TBI) improves functional and histological outcome…”
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Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits by Hoffman, Ann N., Cheng, Jeffrey P., Zafonte, Ross D., Kline, Anthony E.

“…Agitation and aggression are common behavioral sequelae of traumatic brain injury (TBI). The management of these symptoms is critical for effective patient…”
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Hippocampal brain-derived neurotrophic factor mediates recovery from chronic stress-induced spatial reference memory deficits by Ortiz, J. Bryce, Mathewson, Coy M., Hoffman, Ann N., Hanavan, Paul D., Terwilliger, Ernest F., Conrad, Cheryl D.

“…Chronic restraint stress impairs hippocampal‐mediated spatial learning and memory, which improves following a post‐stress recovery period. Here, we…”
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