Search Results - "Hoffert, Todd"

Genetically diverse mouse platform to xenograft cancer cells by Sargent, Jennifer K., Warner, Mark A., Low, Benjamin E., Schott, William H., Hoffert, Todd, Coleman, David, Woo, Xing Yi, Sheridan, Todd, Erattupuzha, Sonia, Henrich, Philipp P., Philip, Vivek M., Chuang, Jeffrey H., Wiles, Michael V., Hasham, Muneer G.

“…The lack of genetically diverse preclinical animal models in basic biology and efficacy testing has been cited as a potential cause of failure in clinical…”
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Abstract 2033: Testing the combined effects of low dose olaparib plus ibrutinib on MCL cytotoxicity by Curtis, Adam D., Hoffert, Todd A., Rajan, Sheila S., Rueter, Jens, Shopland, Lindsay S.

“…Mantle cell lymphoma (MCL) presents a therapeutic challenge, with frequent relapses after therapy due to high levels of DNA damage and disease evolution. One…”
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B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways by Allen, Jessica L., Fore, Matthew S., Wooten, Jenna, Roehrs, Philip A., Bhuiya, Nazmim S., Hoffert, Todd, Sharf, Andrew, Deal, Allison M., Armistead, Paul, Coghill, James, Gabriel, Don A., Irons, Robert, Essenmacher, Amber, Shea, Thomas C., Richards, Kristy, Cutler, Corey, Ritz, Jerome, Serody, Jonathan, Baldwin, Albert S., Sarantopoulos, Stefanie

“…Recent data reveal an important role for B cells in the pathogenesis of chronic GVHD (cGVHD). Patients with cGVHD have delayed B-cell reconstitution and…”
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Increased BCR responsiveness in B cells from patients with chronic GVHD by Allen, Jessica L., Tata, Prasanthi V., Fore, Matthew S., Wooten, Jenna, Rudra, Sharmistha, Deal, Allison M., Sharf, Andrew, Hoffert, Todd, Roehrs, Philip A., Shea, Thomas C., Serody, Jonathan S., Richards, Kristy L., Jagasia, Madan, Lee, Stephanie J., Rizzieri, David, Horwitz, Mitchell E., Chao, Nelson J., Sarantopoulos, Stefanie

“…Although B cells have emerged as important contributors to chronic graft-versus-host-disease (cGVHD) pathogenesis, the mechanisms responsible for their…”
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Abstract 36: Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates (ADCs) demonstrate tumor specificity in vitro and in vivo antitumor efficacy by Prendergast, Jillian M., Eavarone, David A., Rao, Patricia E., Curtis, Adam D., Shopland, Lindsay S., Hoffert, Todd A., Stein, Jenna, Behrens, Jeff, Dransfield, Daniel T.

“…Tumor-associated carbohydrate antigens (TACAs) historically have been challenging targets for antibody therapeutics. Sialyl-Tn (STn) is a cancer specific…”
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Abstract 649: Biobank collaboration enables cancer modeling with high quality biospecimens and data by Shopland, Lindsay S., Emery, Ivette, Hoffert, Todd, Aalberg, Rise, Helbig, Petra, LaPierre, Susan E., Sanders, Vicky, Mills, Kevin D., Hill, Tara, Sheikh, Aysha, Jones, Michael, Breggia, Anne, Rueter, Jens

“…According to the National Cancer Institute, the lack of standardized, high-quality biospecimens is one of the most significant roadblocks to progress in cancer…”
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Bone Marrow Stromal Cells Inhibit Apoptosis of Chronic Lymphocytic Leukemia Cells (CLL) by Expressing Erythroid Differentiation Regulator 1 (ERDR1) by van Deventer, Hendrik W, Hoffert, Todd, West, Michelle L, Wu, Qing Ping, Serody, Jonathan S

“…Abstract 1764 Chemotherapy resistance in chronic lymphocytic leukemia (CLL) is in part mediated by anti-apoptotic signals produced by bone marrow stromal…”
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BCR Hyper-Responsiveness In B Cells From Patients With Chronic Gvhd Is Blocked With The Syk Inhibitor R406 by Allen, Jessica L., Tata, Prasanthi V., Wooten, Jenna, Fore, Matthew S., Deal, Allison M., Sharf, Andrew, Hoffert, Todd, Roehrs, Philip A., Armistead, Paul M., Coghill, James, Wood, William A., Shea, Thomas C., Serody, Jonathan, Richards, Kristy L., Jagasia, Madan, Lee, Stephanie J., Rowe, Krista, Rizzieri, David, Horwitz, Mitchell E., Chao, Nelson J., Sarantopoulos, Stefanie

“…Our previous findings indicate that the excess BAFF present in patients with chronic GVHD (cGVHD) induces increased metabolic activity and B-cell survival ex…”
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