Search Results - "Hofer, Thomas P"

slan-defined subsets of CD16-positive monocytes: impact of granulomatous inflammation and M-CSF receptor mutation by Hofer, Thomas P., Zawada, Adam M., Frankenberger, Marion, Skokann, Kerstin, Satzl, Anna A., Gesierich, Wolfgang, Schuberth, Madeleine, Levin, Johannes, Danek, Adrian, Rotter, Björn, Heine, Gunnar H., Ziegler-Heitbrock, Loems

“…Human monocytes are subdivided into classical, intermediate, and nonclassical subsets, but there is no unequivocal strategy to dissect the latter 2 cell types…”
Get full text

Subsets of CD1c + DCs: Dendritic Cell Versus Monocyte Lineage by Heger, Lukas, Hofer, Thomas P, Bigley, Venetia, de Vries, I Jolanda M, Dalod, Marc, Dudziak, Diana, Ziegler-Heitbrock, Loems

“…Currently three bona fide dendritic cell (DC) types are distinguished in human blood. Herein we focus on type 2 DCs (DC2s) and compare the three defining…”
Get full text

6-Sulfo LacNAc (Slan) as a Marker for Non-classical Monocytes by Hofer, Thomas P, van de Loosdrecht, Arjan A, Stahl-Hennig, Christiane, Cassatella, Marco A, Ziegler-Heitbrock, Loems

“…Monocytes are subdivided into three subsets, which have different phenotypic and functional characteristics and different roles in inflammation and malignancy…”
Get full text

Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis by Martin-Medina, Aina, Lehmann, Mareike, Burgy, Olivier, Hermann, Sarah, Baarsma, Hoeke A., Wagner, Darcy E., De Santis, Martina M., Ciolek, Florian, Hofer, Thomas P., Frankenberger, Marion, Aichler, Michaela, Lindner, Michael, Gesierich, Wolfgang, Guenther, Andreas, Walch, Axel, Coughlan, Christina, Wolters, Paul, Lee, Joyce S., Behr, Jürgen, Königshoff, Melanie

Get full text

Combining HDAC and MEK Inhibitors with Radiation against Glioblastoma-Derived Spheres by Essien, Eno I, Hofer, Thomas P, Atkinson, Michael J, Anastasov, Nataša

“…Glioblastoma stem-like cells (GSLCs) in glioblastoma limit effective treatment and promote therapeutic resistance and tumor recurrence. Using a combined…”
Get full text

Differential inflammatory response to inhaled lipopolysaccharide targeted either to the airways or the alveoli in man by Möller, Winfried, Heimbeck, Irene, Hofer, Thomas P J, Khadem Saba, Gülnaz, Neiswirth, Margot, Frankenberger, Marion, Ziegler-Heitbrock, Löms

“…Endotoxin (Lipopolysaccharide, LPS) is a potent inducer of inflammation and there is various LPS contamination in the environment, being a trigger of lung…”
Get full text

Chemokine expression by small sputum macrophages in COPD by Frankenberger, Marion, Eder, Christiane, Hofer, Thomas P J, Heimbeck, Irene, Skokann, Kerstin, Kassner, Gudrun, Weber, Norbert, Möller, Winfried, Ziegler-Heitbrock, Loems

“…Small sputum macrophages represent highly active cells that increase in the airways of patients with inflammatory diseases such as chronic obstructive…”
Get full text

Decreased expression of HLA-DQ and HLA-DR on cells of the monocytic lineage in cystic fibrosis by Hofer, Thomas P., Frankenberger, Marion, Heimbeck, Irene, Burggraf, Dorothe, Wjst, Matthias, Wright, Adam K. A., Kerscher, Maria, Nährig, Susanne, Huber, Rudolf M., Fischer, Rainald, Ziegler- Heitbrock, Loems

“…We studied HLA class II molecules on blood monocyte subsets, blood dendritic cells, sputum macrophages, and monocyte-derived macrophages at the protein (flow…”
Get full text

Transcript profiling of CD16‐positive monocytes reveals a unique molecular fingerprint by Frankenberger, Marion, Hofer, Thomas P.J., Marei, Ayman, Dayyani, Farshid, Schewe, Stefan, Strasser, Christine, Aldraihim, Asaad, Stanzel, Franz, Lang, Roland, Hoffmann, Reinhard, Costa, Olivia Prazeres da, Buch, Thorsten, Ziegler‐Heitbrock, Loems

“…CD16‐positive (CD14++CD16+ and CD14+CD16++) monocytes have unique features with respect to phenotype and function. We have used transcriptional profiling for…”
Get full text

Standardized single-platform assay for human monocyte subpopulations: Lower CD14⁺CD16⁺⁺ monocytes in females by Heimbeck, Irene, Hofer, Thomas P.J, Eder, Christiane, Wright, Adam K, Frankenberger, Marion, Marei, Ayman, Boghdadi, Ghada, Scherberich, Jürgen, Ziegler-Heitbrock, Loems

“…We present a novel single-platform assay for determination of the absolute number of human blood monocyte subpopulations, i.e., the CD14⁺⁺CD16⁻ and the…”
Get full text

Toward a refined definition of monocyte subsets by Ziegler-Heitbrock, Loems, Hofer, Thomas P J

“…In a nomenclature proposal published in 2010 monocytes were subdivided into classical and non-classical cells and in addition an intermediate monocyte subset…”
Get full text

Darkfield-confocal microscopy detection of nanoscale particle internalization by human lung cells by Gibbs-Flournoy, Eugene A, Bromberg, Philip A, Hofer, Thomas P J, Samet, James M, Zucker, Robert M

“…Concerns over the health effects of nanomaterials in the environment have created a need for microscopy methods capable of examining the biological…”
Get full text

An Integrated Imaging Approach to the Study of Oxidative Stress Generation by Mitochondrial Dysfunction in Living Cells by Cheng, Wan-Yun, Tong, Haiyan, Miller, Evan W., Chang, Christopher J., Remington, James, Zucker, Robert M., Bromberg, Philip A., Samet, James M., Hofer, Thomas P.J.

“…Background: The mechanisms of action of many environmental agents commonly involve oxidative stress resulting from mitochondrial dysfunction. Zinc is a common…”
Get full text

Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoids by Hofer, Thomas P J, Frankenberger, Marion, Mages, Jorg, Lang, Roland, Meyer, Peter, Hoffmann, Reinhard, Colige, Alain, Ziegler-Heitbrock, Loms

“…The regulated expression of ADAMTS2 ( a d isintegrin a nd m etalloproteinase with t hrombo s pondin motifs), a secreted metalloproteinase involved in the…”
Get full text

Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis by Martin-Medina, Aina, Lehmann, Mareike, Burgy, Olivier, Hermann, Sarah, Baarsma, Hoeke A, Wagner, Darcy E, De Santis, Martina M, Ciolek, Florian, Hofer, Thomas P, Frankenberger, Marion, Aichler, Michaela, Lindner, Michael, Gesierich, Wolfgang, Guenther, Andreas, Walch, Axel, Coughlan, Christina, Wolters, Paul, Lee, Joyce S, Behr, Jürgen, Königshoff, Melanie

“…Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by lung epithelial cell injury, increased (myo)fibroblast activation, and…”
Get full text

Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1 by Albrecht, Valerie, Hofer, Thomas P J, Foxwell, Brian, Frankenberger, Marion, Ziegler-Heitbrock, Loems

“…While dendritic cells (DCs) can induce tolerance in T cells, little is known about tolerance induction in DCs themselves. We have analysed tolerance induced in…”
Get full text

Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors by Wright, Adam K. A., Rao, Satish, Range, Simon, Eder, Christiane, Hofer, Thomas P. J., Frankenberger, Marion, Kobzik, Lester, Brightling, Chris, Grigg, Jonathan, Ziegler–Heitbrock, Loems

“…In the airways of classical CF cases there is a high number of newly immigrated small macrophages, which are disabled with respect to scavenger…”
Get full text

Interleukin-10 counteracts T-helper type 1 responses in B-cell lymphoma and is a target for tumor immunotherapy by Ma, Yanchun, Bauer, Vera, Riedel, Tanja, Ahmetlić, Fatima, Hömberg, Nadine, Hofer, Thomas P., Röcken, Martin, Mocikat, Ralph

“…To establish strategies for immunotherapy of B-cell lymphoma, it is mandatory to gain deeper insights into the mechanisms of tumor immune escape. In a mouse…”
Get full text

A defect of CD16-positive monocytes can occur without disease by Frankenberger, Marion, Ekici, Arif B, Angstwurm, Matthias W, Hoffmann, Harald, Hofer, Thomas P.J, Heimbeck, Irene, Meyer, Peter, Lohse, Peter, Wjst, Matthias, Häussinger, Karl, Reis, André, Ziegler-Heitbrock, Loems

“…Abstract The CD16-positive monocytes have been first described in 1988 but to date no selective defect in the number of these cells in blood has been reported…”
Get full text

Antiviral CD8 + T-cell immune responses are impaired by cigarette smoke and in COPD by Chen, Jie, Wang, Xinyuan, Schmalen, Adrian, Haines, Sophia, Wolff, Martin, Ma, Huan, Zhang, Huabin, Stoleriu, Mircea Gabriel, Nowak, Johannes, Nakayama, Misako, Bueno, Marta, Brands, Judith, Mora, Ana L, Lee, Janet S, Krauss-Etschmann, Susanne, Dmitrieva, Anna, Frankenberger, Marion, Hofer, Thomas P, Noessner, Elfriede, Moosmann, Andreas, Behr, Jürgen, Milger, Katrin, Deeg, Cornelia A, Staab-Weijnitz, Claudia A, Hauck, Stefanie M, Adler, Heiko, Goldmann, Torsten, Gaede, Karoline I, Behrends, Jochen, Kammerl, Ilona E, Meiners, Silke

“…Virus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8 T-cells by viral epitopes…”
Get more information