Search Results - "Hofele, Christof"

APOS—antibiotic prophylaxis for preventing infectious complications in orthognathic surgery: study protocol for a phase III, multicentre, randomised, controlled, double blinded, clinical trial with two parallel study arms by Ristow, Oliver, Hofele, Christof, Münch, Philipp, Danner, Sylvia, Dietzel, Anja, Krisam, Johannes, Klose, Christina, Pilz, Maximilian, Hoffmann, Jürgen, Freudlsperger, Christian

“…Abstract Background It is a constant debate among surgeons whether the use of prolonged postoperative antibiotics may reduce surgical site infection rates. As…”
Get full text

Activation of MAP Kinase Signaling Through ERK5 But Not ERK1 Expression Is Associated with Lymph Node Metastases in Oral Squamous Cell Carcinoma (OSCC) by Sticht, Carsten, Freier, Kolja, Knöpfle, Karl, Flechtenmacher, Christa, Pungs, Susanne, Hofele, Christof, Hahn, Meinhard, Joos, Stefan, Lichter, Peter

“…In an attempt to further elucidate the pathomechanisms in oral squamous cell carcinoma (OSCC), gene expression profiling was performed using a…”
Get full text

Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma by Freier, Kolja, Knoepfle, Karl, Flechtenmacher, Christa, Pungs, Susanne, Devens, Frauke, Toedt, Grischa, Hofele, Christof, Joos, Stefan, Lichter, Peter, Radlwimmer, Bernhard

“…Gene copy number aberrations are involved in oral squamous cell carcinoma (OSCC) development. To delineate candidate genes inside critical chromosomal regions,…”
Get full text

The role of elective supraomohyoidal neck dissection in the treatment of early, node-negative oral squamous cell carcinoma (OSCC): A retrospective analysis of 122 cases by Thiele, Oliver C, Seeberger, Robin, Flechtenmacher, Christa, Hofele, Christof, Freier, Kolja

“…Abstract The adequate treatment of the neck in early, clinically node-negative oral squamous cell carcinoma (OSCC) remains controversial. To assess whether…”
Get full text

Interdisciplinary combined treatment of craniofacial osteosarcoma with neoadjuvant and adjuvant chemotherapy and excision of the tumour: a retrospective study by Thiele, Oliver C, Freier, Kolja, Bacon, Claire, Egerer, Gerlinde, Hofele, Christof M

“…Abstract Osteosarcomas are highly malignant tumours of bone, and are rare in the craniofacial area. They account for only 1% of all head and neck malignancies…”
Get full text

Neoadjuvant concurrent radiochemotherapy followed by surgery in advanced oral squamous cell carcinoma (OSCC): A retrospective analysis of 207 patients by Freier, Kolja, Engel, Michael, Lindel, Katja, Flechtenmacher, Christa, Mühling, Joachim, Hassfeld, Stefan, Hofele, Christof

“…Summary Locally advanced operable oral squamous cell carcinoma (OSCC) continues to be a major therapeutic challenge despite the implementation of novel…”
Get full text

Oral health-related quality of life and depression/anxiety in long-term recurrence-free patients after treatment for advanced oral squamous cell cancer by Hassel, Alexander J, Danner, Daniel, Freier, Kolja, Hofele, Christof, Becker-Bikowski, Kirsten, Engel, Michael

“…Abstract This report focuses on the association between oral health-related quality of life (OHRQoL) and depression/anxiety of a homogeneous group of cancer…”
Get full text

Aberrant expression of p53, p16INK4a and Ki-67 as basic biomarker for malignant progression of oral leukoplakias by Nasser, Wasim, Flechtenmacher, Christa, Holzinger, Dana, Hofele, Christof, Bosch, Franz X.

“…J Oral Pathol Med (2011) 40: 629–635 Background:  The risk of malignant progression of oral leukoplakia with and without dysplasia is unpredictable. Materials…”
Get full text

Frequent high telomerase reverse transcriptase expression in primary oral squamous cell carcinoma by Freier, Kolja, Pungs, Susanne, Flechtenmacher, Christa, Bosch, Franz X., Lichter, Peter, Joos, Stefan, Hofele, Christof

“…Background:  Gene copy number gain of chromosomal arm 5p is frequently found in oral squamous cell carcinoma (OSCC) suggesting the activation of…”
Get full text

Haemangiopericytoma of the mandible by Thiele, Oliver C., MD, DDS, Freier, Kolja, MD, DDS, Flechtenmacher, Christa, MD, Rohde, Stefan, MD, Hofele, Christof, MD, DDS, Mühling, Joachim, MD, DDS, Seeberger, Robin, MD, DDS

“…Summary Haemangiopericytomas (HPCs) found in bony structures are rare sarcomas of vascular origin. Here, we report the case of a 41-year-old female with a HPC…”
Get full text

Recurrent Chromosomal Imbalances Detected in Biopsy Material from Oral Premalignant and Malignant Lesions by Combined Tissue Microdissection, Universal DNA Amplification, and Comparative Genomic Hybridization by Weber, Ruthild G., Scheer, Martin, Born, I. Antonio, Joos, Stefan, Cobbers, J. M. J. Ludwig, Hofele, Christof, Reifenberger, Guido, Zöller, Joachim E., Lichter, Peter

“…Biopsies routinely performed for the histopathological diagnosis of oral epithelial lesions before treatment were screened for chromosomal imbalances by…”
Get full text

Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC) by Freier, Kolja, Schwaenen, Carsten, Sticht, Carsten, Flechtenmacher, Christa, Mühling, Joachim, Hofele, Christof, Radlwimmer, Bernhard, Lichter, Peter, Joos, Stefan

“…Summary Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes…”
Get full text

Occurrence of cervical lymph node metastasis of maxillary squamous cell carcinoma – A monocentric study of 171 patients by Berger, Moritz, Grau, Eva, Saure, Daniel, Ristow, Oliver, Thiele, Oliver, Hofele, Christof, Hoffmann, Juergen, Seeberger, Robin, Freier, Kolja

“…Abstract Introduction Fewer than 5% of oral squamous cell carcinomas (SCC) are presented in the maxilla. The absence of cervical lymph node metastasis (LNM) is…”
Get full text

Clinical use of navigation based on cone-beam computer tomography in maxillofacial surgery by Eggers, Georg, Mühling, Joachim, Hofele, Christof

“…Abstract Image-guidance in maxillofacial surgery is based predominantly on computed tomographic (CT) images. Its main disadvantage is the considerable amount…”
Get full text

Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma by FREIER, Kolja, JOOS, Stefan, FLECHTENMACHER, Christa, DEVENS, Frauke, BENNER, Axel, BOSCH, Franz X, LICHTER, Peter, HOFELE, Christof

“…Fluorescence in situ hybridization was applied on a collection of 609 squamous cell carcinomas of the head and neck (HNSCCs),including 511 primary carcinomas…”
Get full text

High survivin expression is associated with favorable outcome in advanced primary oral squamous cell carcinoma after radiation therapy by Freier, Kolja, Pungs, Susanne, Sticht, Carsten, Flechtenmacher, Christa, Lichter, Peter, Joos, Stefan, Hofele, Christof

“…Oral squamous cell carcinoma (OSCC) is a solid neoplasm exhibiting aggressive tumor phenotypes with unpredictable biological behavior. Recent studies suggested…”
Get full text

Cytogenetic characterization of head and neck squamous cell carcinoma cell lines as model systems for the functional analyses of tumor-associated genes by Freier, Kolja, Hofele, Christof, Knoepfle, Karl, Gross, Madeleine, Devens, Frauke, Dyckhoff, Gerhard, Plinkert, Peter, Lichter, Peter, Herold-Mende, Christel

“…J Oral Pathol Med (2010) 39: 382–389 Head and neck squamous cell carcinoma (HNSCC) is a solid malignant neoplasm exhibiting aggressive phenotypes and high…”
Get full text

Changes in the mandibular and dento-alveolar structures by the use of tooth borne mandibular symphyseal distraction devices by Seeberger, Robin, Kater, Wolfgang, Davids, Rolf, Thiele, Oliver C, Edelmann, Boris, Hofele, Christof, Freier, Kolja

“…Abstract Purpose Different devices to perform a mandibular symphyseal distraction osteogenesis (MSDO) are available. This study evaluates how tooth borne…”
Get full text

High 2-[18 F]fluoro-2-deoxy- d -glucose (18 FDG) uptake measured by positron emission tomography is associated with reduced overall survival in patients with oral squamous cell carcinoma by Hofele, Christof, Freier, Kolja, Thiele, Oliver C, Haberkorn, Uwe, Buchmann, Inga

“…Summary Patients with oral squamous cell carcinoma (OSCC) and poor prognosis may benefit from an intensification of the initial therapy scheme. To improve the…”
Get full text

Recurrent coamplification of cytoskeleton-associated genes EMS1 and SHANK2 with CCND1 in oral squamous cell carcinoma by Freier, Kolja, Sticht, Carsten, Hofele, Christof, Flechtenmacher, Christa, Stange, Daniel, Puccio, Laura, Toedt, Grischa, Radlwimmer, Bernhard, Lichter, Peter, Joos, Stefan

“…Chromosomal band 11q13 is frequently amplified in oral squamous cell carcinoma (OSCC) and assumed to be critically involved in tumor initiation and progression…”
Get full text