Search Results - "Hof, Rob J."

Open source software for semi-automated histomorphometry of bone resorption and formation parameters by van't Hof, Rob J, Rose, Lorraine, Bassonga, Euphemie, Daroszewska, Anna

“…Abstract Micro-CT analysis has become the standard method for assessing bone volume and architecture in small animals. However, micro-CT does not allow the…”
Get full text

IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health by Jaffery, Hussain, Huesa, Carmen, Chilaka, Sabarinadh, Cole, John, Doonan, James, Akbar, Moeed, Dunning, Lynette, Tanner, Kathleen Elizabeth, ‘t Hof, Rob J., McInnes, Iain B., Carmody, Ruaidhrí J., Goodyear, Carl S.

“…Objective IĸB protein B cell lymphoma 3‐encoded protein (BCL3) is a regulator of the NF‐κB family of transcription factors. NF‐κB signaling fundamentally…”
Get full text

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology by Huesa, Carmen, Ortiz, Ana C, Dunning, Lynette, McGavin, Laura, Bennett, Louise, McIntosh, Kathryn, Crilly, Anne, Kurowska-Stolarska, Mariola, Plevin, Robin, van 't Hof, Rob J, Rowan, Andrew D, McInnes, Iain B, Goodyear, Carl S, Lockhart, John C, Ferrell, William R

“…Proteinase-activated receptor 2 (PAR2) deficiency protects against cartilage degradation in experimental osteoarthritis (OA). The wider impact of this pathway…”
Get more information

Low protein intake during reproduction compromises the recovery of lactation‐induced bone loss in female mouse dams without affecting skeletal muscles by Kanakis, Ioannis, Alameddine, Moussira, Scalabrin, Mattia, ‘t Hof, Rob J., Liloglou, Triantafillos, Ozanne, Susan E., Goljanek‐Whysall, Katarzyna, Vasilaki, Aphrodite

“…Lactation‐induced bone loss occurs due to high calcium requirements for fetal growth but skeletal recovery is normally achieved promptly postweaning. Dietary…”
Get full text

Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis by Kanakis, Ioannis, Liu, Ke, Poulet, Blandine, Javaheri, Behzad, Hof, Rob J., Pitsillides, Andrew A., Bou‐Gharios, George

“…Objective Cartilage destruction in osteoarthritis (OA) is mediated mainly by matrix metalloproteinases (MMPs) and ADAMTS. The therapeutic candidature of…”
Get full text

The effect of raloxifene on bone marrow adipose tissue and bone turnover in postmenopausal women with osteoporosis by Beekman, Kerensa M., Veldhuis-Vlug, Annegreet G., den Heijer, Martin, Maas, Mario, Oleksik, Ania M., Tanck, Michael W., Ott, Susan M., van 't Hof, Rob J., Lips, Paul, Bisschop, Peter H., Bravenboer, Nathalie

“…In patients with postmenopausal osteoporosis low bone volume is associated with high bone marrow adipose tissue (MAT). Moreover, high MAT is associated with…”
Get full text

The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption by Wani, Sachin, Daroszewska, Anna, Salter, Donald M, van 't Hof, Rob J, Ralston, Stuart H, Albagha, Omar M E

“…Paget's disease of bone (PDB) is characterized by focal increases in bone remodelling. Genome-wide association studies identified a susceptibility locus for…”
Get full text

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity by Loveridge, Carolyn J., van ’t Hof, Rob J., Charlesworth, Gemma, King, Ayala, Tan, Ee Hong, Rose, Lorraine, Daroszewska, Anna, Prior, Amanda, Ahmad, Imran, Welsh, Michelle, Mui, Ernest J., Ford, Catriona, Salji, Mark, Sansom, Owen, Blyth, Karen, Leung, Hing Y.

“…Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1 -mediated Cre expression is a useful…”
Get full text

Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro by Idris, Aymen I., Rojas, Javier, Greig, Iain R., van’t Hof, Rob J., Ralston, Stuart H.

“…Bisphosphonates are widely used for the treatment of bone diseases associated with increased osteoclastic bone resorption. Bisphosphonates are known to inhibit…”
Get full text

Nitric oxide and bone by Van'T Hof, Rob J., Ralston, Stuart H.

“…Summary Nitric oxide (NO) is a free radical which has important effects on bone cell function. The endothelial isoform of nitric oxide synthase (eNOS) is…”
Get full text

Insertion Mutation in Tnfrsf11a Causes a Paget's Disease–Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice by Alonso, Nerea, Wani, Sachin, Rose, Lorraine, van't Hof, Rob J., Ralston, Stuart H., Albagha, Omar M.E.

“…ABSTRACT Early onset familial Paget's disease of bone (EoPDB), familial expansile osteolysis, and expansile skeletal hyperphosphatasia are related disorders…”
Get full text

Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice by Coste, Emmanuel, Greig, Iain R, Mollat, Patrick, Rose, Lorraine, Gray, Mohini, Ralston, Stuart H, van 't Hof, Rob J

“…Inflammatory joint diseases such as rheumatoid arthritis are associated with local bone erosions and systemic bone loss, mediated by increased osteoclastic…”
Get more information

Mitigating lead-induced osteoporosis: The role of butyrate in gut-bone axis restoration by Ge, Yuqiu, Jia, Zhongtang, Zhao, Shiting, Zhang, WenChao, Shi, Xian, Xie, Ruijin, Gong, Yan, Sheng, Jixiang, van 't Hof, Rob J., Yang, Jiatao, Han, Chunqing, Hu, Xiping, Wang, Yafeng, Wu, Yu, Li, Chunping, Wang, Miaomiao

“…Lead (Pb) is an environmentally widespread bone toxic pollutant, contributes to the development of osteoporosis. Butyric acid, mainly produced by the…”
Get full text

The essential requirement for Runx1 in the development of the sternum by Liakhovitskaia, Anna, Lana-Elola, Eva, Stamateris, Evangelos, Rice, David P., van 't Hof, Rob J., Medvinsky, Alexander

“…Runx1 is highly expressed in chondroprogenitor and osteoprogenitor cells and in vitro experiments suggest that Runx1 is important in the early stages of…”
Get full text

Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro by Bakker, Astrid D., Huesa, Carmen, Hughes, Alun, Aspden, Richard M., van’t Hof, Rob J., Klein-Nulend, Jenneke, Helfrich, Miep H.

“…Endothelial nitric oxide synthase (eNOS) has long been held responsible for NO production by mechanically stimulated osteoblasts, but this has recently been…”
Get full text

Identification of Novel Biphenyl Carboxylic Acid Derivatives as Novel Antiresorptive Agents that Do Not Impair Parathyroid Hormone-Induced Bone Formation by Idris, Aymen I, Greig, Iain R, Bassonga-Landao, Euphemie, Ralston, Stuart H, van 't Hof, Rob J

“…Bisphosphonates are widely used in the treatment of osteoporosis, but they inhibit bone formation and blunt the anabolic effect of PTH. Here we describe a…”
Get full text

The Biphenyl-Carboxylate Derivative ABD328 is a Novel Orally Active Antiresorptive Agent by Idris, Aymen I., Coste, Emmanuel, Greig, Iain R., Ralston, Stuart H., van’t Hof, Rob J.

“…We previously described a novel series of biphenyl carboxylic acid derivatives which have potent antiresorptive effects in vitro and in vivo and do not affect…”
Get full text

Discovery of biphenylketones as dual modulators of inflammation and bone loss by Greig, Iain R., Coste, Emmanuel, Ralston, Stuart H., van’t Hof, Rob J.

“…Biphenylketones were identified as novel inhibitors of NFκB activation. Structure–activity studies led to the identification of compound 4c, which had good…”
Get full text

microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity by Hayman, Dan J., Johnson de Sousa Brito, Francesca M., Lin, Hua, Prior, Amanda, Charlesworth, Gemma, Hao, Yao, Pearson, Rachel D., Soul, Jamie, Clark, Ian M., Piróg, Katarzyna A., Barter, Matt J., van't Hof, Rob J., Young, David A.

“…MicroRNAs (miRNAs) modulate the expression of other RNA molecules. One miRNA can target many transcripts, allowing each miRNA to play key roles in many…”
Get full text

Identification of Biphenylcarboxylic Acid Derivatives as a Novel Class of Bone Resorption Inhibitors by van 't Hof, Rob J, Idris, Aymen I, Ridge, Susan A, Dunford, James, Greig, Iain R, Ralston, Stuart H

“…A novel class of biphenylcarboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and…”
Get full text