Search Results - "Hoernschemeyer, Joerg"

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
Get full text

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody by Favuzza, Paola, Guffart, Elena, Tamborrini, Marco, Scherer, Bianca, Dreyer, Anita M, Rufer, Arne C, Erny, Johannes, Hoernschemeyer, Joerg, Thoma, Ralf, Schmid, Georg, Gsell, Bernard, Lamelas, Araceli, Benz, Joerg, Joseph, Catherine, Matile, Hugues, Pluschke, Gerd, Rudolph, Markus G

“…Invasion of erythrocytes by merozoites is a composite process involving the interplay of several proteins. Among them, the Cysteine-Rich Protective Antigen…”
Get full text

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport by Ruderisch, Nadine, Schlatter, Daniel, Kuglstatter, Andreas, Guba, Wolfgang, Huber, Sylwia, Cusulin, Carlo, Benz, Jörg, Rufer, Arne Christian, Hoernschemeyer, Joerg, Schweitzer, Christophe, Bülau, Tina, Gärtner, Achim, Hoffmann, Eike, Niewoehner, Jens, Patsch, Christoph, Baumann, Karlheinz, Loetscher, Hansruedi, Kitas, Eric, Freskgård, Per-Ola

“…Therapeutic approaches to fight Alzheimer's disease include anti-Amyloidβ (Aβ) antibodies and secretase inhibitors. However, the blood-brain barrier (BBB)…”
Get full text

Metabolism of the unnatural anticancer lipid safingol, l-threo-dihydrosphingosine, in cultured cells by Dragusin, Mihaela, Gurgui, Cristian, Schwarzmann, Günter, Hoernschemeyer, Joerg, van Echten-Deckert, Gerhild

“…We studied the metabolism of radioactively labeled safingol (l-threo-dihydrosphingosine) in primary cultured neurons, B104 neuroblastoma cells, and Swiss 3T3…”
Get full text

Expression of the GM2-activator protein in the methylotrophic yeast Pichia pastoris, purification, isotopic labeling, and biophysical characterization by Wendeler, Michaela, Hoernschemeyer, Joerg, John, Michael, Werth, Norbert, Schoeniger, Maike, Lemm, Thorsten, Hartmann, Rudolf, Kessler, Horst, Sandhoff, Konrad

“…The GM2-activator protein (GM2AP) belongs to a group of five small, nonenzymatic proteins that are essential cofactors for the degradation of…”
Get full text

Expression of recombinant human GM2-activator protein in insect cells: purification and characterization by mass spectrometry by Wendeler, Michaela, Lemm, Thorsten, Weisgerber, Judith, Hoernschemeyer, Joerg, Bartelsen, Oliver, Schepers, Ute, Sandhoff, Konrad

“…The GM2-activator protein (GM2AP) is a small non-enzymatic cofactor assisting the enzyme β-hexosaminidase A in the lysosomal degradation of ganglioside GM2…”
Get full text

Development of stable liquid formulations for oligonucleotides by Poecheim, Johanna, Graeser, Kirsten A., Hoernschemeyer, Joerg, Becker, Gerhard, Storch, Kirsten, Printz, Miriam

“…[Display omitted] Oligonucleotide-based therapeutics have been implemented as a new therapeutic modality in biotech industry, which offers the opportunity to…”
Get full text

Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes by Wubbolts, Richard, Leckie, Rachel S., Veenhuizen, Peter T.M., Schwarzmann, Guenter, Möbius, Wiebke, Hoernschemeyer, Joerg, Slot, Jan-Willem, Geuze, Hans J., Stoorvogel, Willem

“…Exosomes are 60–100-nm membrane vesicles that are secreted into the extracellular milieu as a consequence of multivesicular body fusion with the plasma…”
Get full text

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation by Wubbolts, Richard, Leckie, Rachel S, Veenhuizen, Peter T M, Schwarzmann, Guenter, Möbius, Wiebke, Hoernschemeyer, Joerg, Slot, Jan-Willem, Geuze, Hans J, Stoorvogel, Willem

“…Exosomes are 60-100-nm membrane vesicles that are secreted into the extracellular milieu as a consequence of multivesicular body fusion with the plasma…”
Get full text

Glycation during storage and administration of monoclonal antibody formulations by Fischer, Stefan, Hoernschemeyer, Joerg, Mahler, Hanns-Christian

“…Covalent modifications of therapeutic proteins are of interest for the biotech industry as they potentially impact the quality of the material. This study…”
Get full text

Distinguishing the topology of macrocyclic compounds and catenanes by Schalley, Christoph A., Hoernschemeyer, Joerg, Li, Xiyou, Silva, Gabriele, Weis, Patrick

“…The paper explores different possibilities to distinguish macrocyclic oligolactam species with different molecular topologies by ESI mass spectrometry…”
Get full text

Photoaffinity labelling of the human GM2-activator protein. Mechanistic insight into ganglioside GM2 degradation by Wendeler, Michaela, Hoernschemeyer, Joerg, Hoffmann, Daniel, Kolter, Thomas, Schwarzmann, Guenter, Sandhoff, Konrad

“…The GM2-activator protein (GM2AP) is an essential cofactor for the degradation of ganglioside GM2 by lysosomal beta-hexosaminidase A. It mediates the…”
Get full text

Recombinant ganglioside GM2 synthase--expression in insect cells and enzyme assay by Wendeler, Michaela, Reilaender, Helmut, Hoernschemeyer, Joerg, Schwarzmann, Guenter, Kolter, Thomas, Sandhoff, Konrad

Get more information

Human acid sphingomyelinase: Assignment of the disulfide bond pattern by Lansmann, Stephanie, Schuette, Christina G., Bartelsen, Oliver, Hoernschemeyer, Joerg, Linke, Thomas, Weisgerber, Judith, Sandhoff, Konrad

“…Human acid sphingomyelinase (haSMase, EC 3.1.4.12) catalyzes the lysosomal degradation of sphingomyelin to ceramide and phosphorylcholine. An inherited haSMase…”
Get full text

Photoaffinity labelling of the Human GM2‐activator protein by Wendeler, Michaela, Hoernschemeyer, Joerg, Hoffmann, Daniel, Kolter, Thomas, Schwarzmann, Guenter, Sandhoff, Konrad

“…The GM2‐activator protein (GM2AP) is an essential cofactor for the degradation of ganglioside GM2 by lysosomal β‐hexosaminidase A. It mediates the interaction…”
Get full text

Human acid sphingomyelinase by Lansmann, Stephanie, Schuette, Christina G., Bartelsen, Oliver, Hoernschemeyer, Joerg, Linke, Thomas, Weisgerber, Judith, Sandhoff, Konrad

“…Human acid sphingomyelinase (haSMase, EC 3.1.4.12) catalyzes the lysosomal degradation of sphingomyelin to ceramide and phosphorylcholine. An inherited haSMase…”
Get full text