Search Results - "Hoenke, Christoph"

Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI‑3231, a Well-Characterized Chemical Probe Available for Open Science by Thamm, Sven, Willwacher, Marina K., Aspnes, Gary E., Bretschneider, Tom, Brown, Nicholas F., Buschbom-Helmke, Silke, Fox, Thomas, Gargano, Emanuele M., Grabowski, Daniel, Hoenke, Christoph, Matera, Damian, Mueck, Katja, Peters, Stefan, Reindl, Sophia, Riether, Doris, Schmid, Matthias, Tautermann, Christofer S., Teitelbaum, Aaron M., Trünkle, Cornelius, Veser, Thomas, Winter, Martin, Wortmann, Lars

“…Genome-wide association studies in patients revealed HSD17B13 as a potential new target for the treatment of nonalcoholic steatohepatitis (NASH) and other…”
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Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies by Fer, Mickael, Amalric, Camille, Arban, Roberto, Baron, Luc, Ben Hamida, Sami, Breh-Schlanser, Petra, Cui, Yunhai, Darcq, Emmanuel, Eickmeier, Christian, Faye, Vincent, Franchet, Christel, Frauli, Mélanie, Halter, Célia, Heyer, Marjorie, Hoenke, Christoph, Hoerer, Stefan, Hucke, Oliver T., Joseph, Christophe, Kieffer, Brigitte L., Lebrun, Louison, Lotz, Noémie, Mayer, Stanislas, Omrani, Azar, Recolet, Mandy, Schaeffer, Laurent, Schann, Stephan, Schlecker, Annette, Steinberg, Edith, Viloria, Mélanie, Würstle, Klaus, Young, Kyle, Zinser, Alexander, Montel, Florian, Klepp, Julian

“…Decreased activity and expression of the G-protein coupled receptor GPR88 is linked to many behavior-linked neurological disorders. Published preclinical GPR88…”
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Identification of New Potent GPR119 Agonists by Combining Virtual Screening and Combinatorial Chemistry by Wellenzohn, Bernd, Lessel, Uta, Beller, Andreas, Isambert, Timo, Hoenke, Christoph, Nosse, Bernd

“…Virtual screening in a huge collection of virtual combinatorial libraries has led to the identification of two new structural classes of GPR119 agonists with…”
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Synthesis of Triazolyl-Substituted 3-Aminopiperidines by Huisgen-1,3-Dipolar Cycloaddition - New Scaffolds for Combinatorial Chemistry by Schramm, Heiko, Saak, Wolfgang, Hoenke, Christoph, Christoffers, Jens

“…Orthogonally N‐protected (Boc and Cbz) 4‐(1,2,3‐triazol‐4‐yl)‐substituted 3‐aminopiperidines are new scaffolds for combinatorial chemistry. They were prepared…”
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Use of 5-hydroxy-4H-benzo[1,4]oxazin-3-ones as β2-adrenoceptor agonists by HOENKE, Christoph, BOUYSSOU, Thierry, TAUTERMANN, Christofer S, RUDOLF, Klaus, SCHNAPP, Andreas, KONETZKI, Ingo

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A New Synthesis of Sulfur-, Nitrogen- and Oxygen-Containing Eight-Membered Ring Lactams by Pflantz, Rebekka, Sluiter, Jonas, Krička, Mario, Saak, Wolfgang, Hoenke, Christoph, Christoffers, Jens

“…Bi(NO3)3‐catalyzed ring expansion of five‐membered ring 1,4‐diketones in the presence of primary amines leads to eight‐membered ring lactams. When applied to…”
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Studies towards topical selective β2-adrenoceptor agonists with a long duration of action by BOUYSSOU, Thierry, RUDOLF, Klaus, HOENKE, Christoph, LUSTENBERGER, Philipp, SCHNAPP, Andreas, KONETZKI, Ingo

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Eight-Membered-Ring Lactams - New Scaffolds for Combinatorial Chemistry Prepared by Ring-Expansion of 1,4-Diketones with Primary Amines by Pflantz, Rebekka, Tielmann, Patrick, Rössle, Michael, Hoenke, Christoph, Christoffers, Jens

“…Eight‐membered‐ring lactams were prepared by the Bi‐catalyzed reaction of 1,4‐diketones with primary amines. These lactams define a new type of non‐planar…”
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Studies towards topical selective b sub(2)-adrenoceptor agonists with a long duration of action by Bouyssou, Thierry, Rudolf, Klaus, Hoenke, Christoph, Lustenberger, Philipp, Schnapp, Andreas, Konetzki, Ingo

“…b sub(2)-Adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the phenyl ethanolamine core were prepared and investigated in…”
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Studies towards topical selective β 2-adrenoceptor agonists with a long duration of action by Bouyssou, Thierry, Rudolf, Klaus, Hoenke, Christoph, Lustenberger, Philipp, Schnapp, Andreas, Konetzki, Ingo

“…β 2-Adrenoceptor agonists with basic and acidic groups R were prepared and investigated in vitro and in vivo. β 2-Adrenoceptor agonists with basic and acidic…”
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Use of 5-hydroxy-4 H-benzo[1,4]oxazin-3-ones as β 2-adrenoceptor agonists by Hoenke, Christoph, Bouyssou, Thierry, Tautermann, Christofer S., Rudolf, Klaus, Schnapp, Andreas, Konetzki, Ingo

“…β 2-Adrenoceptor agonists with different substituents R were prepared and investigated in vitro and in vivo. Novel β 2-agonists with a 5-hydroxy-4…”
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Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy by Bouyssou, Thierry, Hoenke, Christoph, Rudolf, Klaus, Lustenberger, Philipp, Pestel, Sabine, Sieger, Peter, Lotz, Ralf, Heine, Claudia, Büttner, Frank H., Schnapp, Andreas, Konetzki, Ingo

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Discovery of olodaterol, a novel inhaled β 2-adrenoceptor agonist with a 24 h bronchodilatory efficacy by Bouyssou, Thierry, Hoenke, Christoph, Rudolf, Klaus, Lustenberger, Philipp, Pestel, Sabine, Sieger, Peter, Lotz, Ralf, Heine, Claudia, Büttner, Frank H., Schnapp, Andreas, Konetzki, Ingo

“…The discovery of the β 2-adrenoceptor agonist ( R)- 4p designated olodaterol is described. The preclinical profile of the compound suggests a bronchoprotective…”
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Discovery of olodaterol, a novel inhaled β2-drenoceptor agonist with a 24 h bronchodilatory efficacy by BOUYSSOU, Thierry, HOENKE, Christoph, KONETZKI, Ingo, RUDOLF, Klaus, LUSTENBERGER, Philipp, PESTEL, Sabine, SIEGER, Peter, LOTZ, Ralf, HEINE, Claudia, BÜTTNER, Frank H, SCHNAPP, Andreas

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Use of 5-hydroxy-4H-benzo[1,4]oxazin-3-ones as beta2-adrenoceptor agonists by Hoenke, Christoph, Bouyssou, Thierry, Tautermann, Christofer S, Rudolf, Klaus, Schnapp, Andreas, Konetzki, Ingo

“…Novel beta(2)-agonists with a 5-hydroxy-4H-benzo[1,4]oxazin-3-one moiety as head group are described. Systematic chemical variations at the phenethylamine…”
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Studies towards topical selective beta2-adrenoceptor agonists with a long duration of action by Bouyssou, Thierry, Rudolf, Klaus, Hoenke, Christoph, Lustenberger, Philipp, Schnapp, Andreas, Konetzki, Ingo

“…Beta2-adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the phenyl ethanolamine core were prepared and investigated in vitro…”
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Discovery of olodaterol, a novel inhaled beta2-adrenoceptor agonist with a 24 h bronchodilatory efficacy by Bouyssou, Thierry, Hoenke, Christoph, Rudolf, Klaus, Lustenberger, Philipp, Pestel, Sabine, Sieger, Peter, Lotz, Ralf, Heine, Claudia, Büttner, Frank H, Schnapp, Andreas, Konetzki, Ingo

“…Compound 4p was identified from a series of 6-hydroxy-4H-benzo[1,4]oxazin-3-ones as potent agonist of the human beta2-adrenoceptor with a high…”
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Biocatalytic resolutions in total syntheses of purpurosamine and sannamine/sporamine type building blocks of aminoglycoside antibiotics by Yang, Fushun, Hoenke, Christoph, Prinzbach, Horst

“…The efficient enzymatic resolution at a central stage en route from benzene to amino(deoxy) inositols provides 6- epi-sannamine (sporamine) type glycosyl…”
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Synthesis of 3-Phenyl-4-piperidones from Acetophenone by Shapiro and Aza-Michael Reactions and Their Further Derivatization by Rosiak, Anna, Hoenke, Christoph, Christoffers, Jens

“…The Shapiro reaction of acetophenone is the key in a convenient three‐step access to a divinyl ketone which is further transformed by double aza‐Michael…”
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