Search Results - "Hoelzl, Markus"

IFN-γ and tumor gangliosides: Implications for the tumor microenvironment by Dillinger, Barbara, Ahmadi-Erber, Sarah, Lau, Manuel, Hoelzl, Markus A., Erhart, Friedrich, Juergens, Birgit, Fuchs, Dietmar, Heitger, Andreas, Ladisch, Stephan, Dohnal, Alexander M.

“…[Display omitted] •Gangliosides decrease DC activation, co-stimulation and inflammatory cytokines.•IFN-γ does not reverse ganglioside-induced…”
Get full text

The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I) by Hölzl, Markus A., Hofer, Johannes, Kovarik, Johannes J., Roggenbuck, Dirk, Reinhold, Dirk, Goihl, Alexander, Gärtner, Miriam, Steinberger, Peter, Zlabinger, Gerhard J.

“…The pancreatic zymogen granule membrane protein (GP2) is expressed by pancreatic acinar cells and M cells of the ileum. GP2 is the closest related homologue of…”
Get full text

Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts by Kalscheuer, Hannes, Onoe, Takashi, Dahmani, Alexander, Li, Hao-Wei, Hölzl, Markus, Yamada, Kazuhiko, Sykes, Megan

“…Transplantation of xenogeneic thymus tissue allows xenograft tolerance induction in the highly disparate pig-to-mouse model. Fetal swine thymus (SW THY) can…”
Get full text

Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice by Khosravi‐Maharlooei, Mohsen, Hoelzl, Markus, Li, Hao Wei, Madley, Rachel C., Waffarn, Elizabeth E., Danzl, Nichole M., Sykes, Megan

“…We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or…”
Get full text

Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice by Khosravi-Maharlooei, Mohsen, Li, HaoWei, Hoelzl, Markus, Zhao, Guiling, Ruiz, Amanda, Misra, Aditya, Li, Yang, Teteloshvili, Nato, Nauman, Grace, Danzl, Nichole, Ding, Xiaolan, Pinker, Elisha Y., Obradovic, Aleksandar, Yang, Yong-Guang, Iuga, Alina, Creusot, Remi J., Winchester, Robert, Sykes, Megan

“…We evaluated the role of the thymus in development of multi-organ autoimmunity in human immune system (HIS) mice. T cells were essential for disease…”
Get full text

CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk by Mayer, Edda, Hölzl, Markus, Ahmadi, Sarah, Dillinger, Barbara, Pilat, Nina, Fuchs, Dietmar, Wekerle, Thomas, Heitger, Andreas

“…Immunosuppressive cytotoxic T lymphocyte associated antigen-4 immunoglobulin fusion proteins (CTLA4-Ig) block the CD28:CD80/86 costimulatory pathway. On a…”
Get full text

Ig‐like transcript 4 as a cellular receptor for soluble complement fragment C4d by Hofer, Johannes, Forster, Florian, Isenman, David E., Wahrmann, Markus, Leitner, Judith, Hölzl, Markus A., Kovarik, Johannes J., Stockinger, Hannes, Böhmig, Georg A., Steinberger, Peter, Zlabinger, Gerhard J.

“…Complement regulation leads to the generation of complement split products (CSPs) such as complement component (C)4d, a marker for disease activity in…”
Get full text

CTLA4-Ig Preserves Thymus-Derived T Regulatory Cells by Ahmadi, Sarah M, Hölzl, Markus A, Mayer, Edda, Wekerle, Thomas, Heitger, Andreas

“…BACKGROUNDCTLA-4 immunoglobulin fusion proteins (CTLA4-Ig) suppress immune reactions by blocking the T-cell costimulatory CD28–CD80-86 pathway and are used in…”
Get full text

Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis by Kovarik, Johannes J, Kernbauer, Elisabeth, Hölzl, Markus A, Hofer, Johannes, Gualdoni, Guido A, Schmetterer, Klaus G, Miftari, Fitore, Sobanov, Yury, Meshcheryakova, Anastasia, Mechtcheriakova, Diana, Witzeneder, Nadine, Greiner, Georg, Ohradanova-Repic, Anna, Waidhofer-Söllner, Petra, Säemann, Marcus D, Decker, Thomas, Zlabinger, Gerhard J

“…A crucial role of cell metabolism in immune cell differentiation and function has been recently established. Growing evidence indicates that metabolic…”
Get full text

Impaired anti-inflammatory efficacy of n-butyrate in patients with IBD by Kovarik, Johannes J., Tillinger, Wolfgang, Hofer, Johannes, Hölzl, Markus A., Heinzl, Harald, Saemann, Marcus D., Zlabinger, Gerhard J.

“…Eur J Clin Invest 2011; 41 (3): 291–298 Background  The intestinal mucosa of patients with inflammatory bowel diseases (IBD) characteristically shows a high…”
Get full text

Eicosanoid modulation by the short‐chain fatty acid n‐butyrate in human monocytes by Kovarik, Johannes J., Hölzl, Markus A., Hofer, Johannes, Waidhofer‐Söllner, Petra, Sobanov, Yury, Koeffel, René, Saemann, Marcus D., Mechtcheriakova, Diana, Zlabinger, Gerhard J.

“…Summary n‐Butyrate deriving from bacterial fermentation in the mammalian intestine is a key determinant in gastrointestinal homeostasis. We examined the…”
Get full text

Host antimicrobial proteins as endogenous immunomodulators by Hölzl, Markus A, Hofer, Johannes, Steinberger, Peter, Pfistershammer, Katharina, Zlabinger, Gerhard J

“…Abstract Host defense mechanisms are multilayered and involve physical as well as chemical barriers, antimicrobial factors as well as a broad set of…”
Get full text

Quantification of α-galactosidase activity in intact leukocytes by Hölzl, Markus A., Gärtner, Miriam, Kovarik, Johannes J., Hofer, Johannes, Bernheimer, Hanno, Sunder-Plassmann, Gere, Zlabinger, Gerhard J.

“…Mutations of the α-galactosidase (α-Gal) A gene in Fabry disease lead to a severe disturbance in glycosphingolipid catabolism. The atypical clinical picture of…”
Get full text