Search Results - "Hoelz, Derek"

Human C6orf211 Encodes Armt1, a Protein Carboxyl Methyltransferase that Targets PCNA and Is Linked to the DNA Damage Response by Perry, J. Jefferson P., Ballard, Gregory D., Albert, Alexandra E., Dobrolecki, Lacey E., Malkas, Linda H., Hoelz, Derek J.

“…Recent evidence supports the presence of an L-glutamyl methyltransferase(s) in eukaryotic cells, but this enzyme class has been defined only in…”
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cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker by Malkas, Linda H, Herbert, Brittney Shea, Abdel-Aziz, Waleed, Dobrolecki, Lacey E, Liu, Yang, Agarwal, Beamon, Hoelz, Derek, Badve, Sunil, Schnaper, Lauren, Arnold, Randy J, Mechref, Yehia, Novotny, Milos V, Loehrer, Patrick, Goulet, Robert J, Hickey, Robert J

“…Two isoforms of proliferating cell nuclear antigen (PCNA) have been observed in breast cancer cells. Commercially available antibodies to PCNA recognize both…”
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DNA Damage-Induced Phosphorylation of the Human Telomere-Associated Protein TRF2 by Tanaka, Hiromi, Mendonca, Marc S., Paul S. Bradshaw, Derek J. Hoelz, Malkas, Linda H., Meyn, M. Stephen, Gilley, David

“…Several protein kinases from diverse eukaryotes known to perform important roles in DNA repair have also been shown to play critical roles in telomere…”
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DNA-Dependent Conformational Changes in the Ku Heterodimer by Lehman, Jason A, Hoelz, Derek J, Turchi, John J

“…Ionizing radiation induces DNA double-strand breaks which are repaired by the nonhomologous end joining (NHEJ) pathway. NHEJ is initiated upon Ku binding to…”
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Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids by Kumar, Hari R., Zhong, Xiaoling, Hoelz, Derek J., Rescorla, Frederick J., Hickey, Robert J., Malkas, Linda H., Sandoval, John A.

“…Introduction Solid tumors, such as neuroblastoma (NB), are associated with a heterogeneous cell environment. Multicellular tumor spheroid (MCTS) cultures have…”
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Serum Protein Profiling to Identify High-Risk Neuroblastoma: Preclinical Relevance of Blood-Based Biomarkers by Sandoval, John A., M.D, Turner, Katharyn E., B.A, Hoelz, Derek J., Ph.D, Rescorla, Frederick J., M.D, Hickey, Robert J., Ph.D, Malkas, Linda H., Ph.D

“…Introduction Development of early detection assays for advanced stage neuroblastoma (NB) remains elusive. We have previously shown that serum protein profiling…”
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Proteomic Analysis of Neuroblastoma Microenvironment: Effect of the Host–Tumor Interaction on Disease Progression by Turner, Katharyn E., D.O, Kumar, Hari R., M.D, Hoelz, Derek J., Ph.D, Zhong, Xiaoling, M.D., Ph.D, Rescorla, Frederick J., M.D, Hickey, Robert J., Ph.D, Malkas, Linda H., Ph.D, Sandoval, John A., M.D

“…Background Children with advanced-stage neuroblastoma (NB) traditionally experience poor outcomes. Because early detection of advanced-stage disease may impact…”
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The discovery of labile methyl esters on proliferating cell nuclear antigen by MS/MS by Hoelz, Derek J., Arnold, Randy J., Dobrolecki, Lacey E., Abdel-Aziz, Waleed, Loehrer, Andrew P., Novotny, Milos V., Schnaper, Lauren, Hickey, Robert J., Malkas, Linda H.

“…The post‐translational modification of proliferating cell nuclear antigen (PCNA) has been implicated in modulating its function for over 20 years. With…”
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Bin1 is linked to metastatic potential and chemosensitivity in neuroblastoma by Zhong, Xiaoling, Hoelz, Derek J., Kumar, Hari R., Sandoval, John A., Rescorla, Frederick J., Hickey, Robert J., Malkas, Linda H.

“…Background Neuroblastoma (NB) is the most common extracranial solid tumor in children. At the time of diagnosis, the tumor has metastasized in as many as 7 of…”
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Novel peptides secreted from human neuroblastoma: useful clinical tools? by Sandoval, John A., Hoelz, Derek J., Woodruff, Heather A., Powell, Robert L., Jay, Colleen L., Grosfeld, Jay L., HickeyD, Robert J., Malkas, Linda H.

“…Differentially expressed neuroblastoma (NB) proteins are vital for the development of new diagnostics and therapeutics. For example, secretory NB peptides…”
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Armt1: a phoenix rises from the ashes by Hoelz, Derek

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Serum proteome profiles identifies parathyroid hormone physiologic response by Prahalad, Agasanur K., Hickey, Robert J., Huang, Jeffrey, Hoelz, Derek J., Dobrolecki, Lacey, Murthy, Sreemala, Winata, Therry, Hock, Janet M.

“…Parathyroid hormone (amino acids 1–34) (PTH) regulates bone and calcium homeostasis. The magnitude of the effects of PTH on bone varies in osteoporosis…”
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Proteomic Analysis of Neuroblastoma Subtypes in Response to Mitogen-Activated Protein Kinase Inhibition: Profiling Multiple Targets of Cancer Kinase Signaling by Sandoval, John A., Eppstein, Andrew C., Hoelz, Derek J., Klein, Patrick J., Linebarger, Jared H., Turner, Katharyn E., Rescorla, Frederick J., Hickey, Robert J., Malkas, Linda H., Schmidt, Christian M.

“…Survival for high-risk neuroblastoma (NB) remains poor despite aggressive therapy. Novel therapies are vital for improving prognosis. We previously showed…”
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Profiling of nuclear extract proteins from human neuroblastoma cell lines: the search for fingerprints by Escobar, Mauricio A., Hoelz, Derek J., Sandoval, John A., Hickey, Robert J., Grosfeld, Jay L., Malkas, Linda H.

“…Neuroblastoma (NB) commonly presents with advanced disease at diagnosis and is associated with poor survival. If identified early, however, survival is…”
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Serum proteome profiles identifies parathyroid hormone physiologic response by Prahalad, Agasanur K., Hickey, Robert J., Huang, Jeffrey, Hoelz, Derek J., Dobrolecki, Lacey, Murthy, Sreemala, Winata, Therry, Hock, Janet M.

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DNA-Dependent Conformational Changes in the Ku Heterodimer super([dagger]) by Turchi, John J, Lehman, Jason A, Hoelz, Derek J

“…Ionizing radiation induces DNA double-strand breaks which are repaired by the nonhomologous end joining (NHEJ) pathway. NHEJ is initiated upon Ku binding to…”
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Abstract B9: Arm1: A glutamate methyltransferase capable of methyl esterifying PCNA by Hoelz, Derek J., Albert, Alexandra, Dobrolecki, Lacey, Arnold, Randy, Novotny, Milos, Schnaper, Lauren, Hickey, Robert, Malkas, Linda

“…Abstract Recently we reported on a novel post-translational modification (PTM) present on proliferating cell nuclear antigen (PCNA). This PTM (methyl…”
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